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Professor Tomat is broadly interested in the role of transition metals, such as iron, copper and zinc, in human health and disease. A current focus of the Tomat research laboratory is on the involvement of iron in cancer growth. Motivated by the altered iron metabolism of cancer cells when compared to normal cells, we synthesize antiproliferative iron-binding compounds that are activated intracellularly and incorporate design elements to control redox chemistry, cellular uptake, and selectivity towards malignant cells. We are also examining the impact of iron chelators on macrophages and the implication of these immune cells in iron distribution within the tumor microenvironment.Show Less
Courses
- IPInorganic Preparations
- HFCHonors Fundamentals of Chemistry
- AICAdvanced Inorganic Chemistry
- IPInorganic Preparation
Student Thesis/Dissertation
- Natural and Synthetic Oligopyrroles as Chromophores and Electron Reservoirs in Metal Complexes
2020
masters - Disulfide-Masked Prochelators to Target the Iron Metabolism of Cancer: Coordination Chemistry and Antiproliferative Activity in Malignant Cells
2020
doctoral - Synthesis of Pd(II) Complexes Containing Redox-active Dipyrrolic and Tripyrrolic Ligands
2019
masters - Multiscale Lanthanide-Containing Materials: MOFs, Clusters, and Nanomaterials
2018
doctoral - Disulfide-Masked Prochelators Targeting the Iron Metabolism of Cancer: Design, Synthesis, and Biological Investigations
2017
doctoral - Coordination Chemistry of Linear Oligopyrrolic Fragments Inspired By Heme Metabolites
2017
doctoral
Grants
- Redox-Active Biopyrrin Pigments in Supramolecular Radical Assemblies
Principal Investigator (PI)
2022
$481.4KActive - MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education
Principal Investigator (PI)
2021
$266.2KActive - Selective Killing of FH-/- Cancer Cells by Targeting Cellular Iron Homeostasis
Key Personnel (KP)
2018
$1.6MActive - Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy
Principal Investigator (PI)
2018
$1.2MActive - Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy
Principal Investigator (PI)
2018
$31.9KActive - Elucidating the Orchestrated Bacterial Response to Copper Toxicity - Diversity Supplement (UGrad)
Key Personnel (KP)
2018
$13.0KActive - Copper Chelating Compounds as Novel Antimicrobial Class
Key Personnel (KP)
2021
$82.0K - MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona
Co-Investigator (COI)
2019
$500.8K - CAREER: Interplay of Metal Coordination and Ligand-Based Reactivity in Complexes of Oligopyrrolic Fragments
Principal Investigator (PI)
2015
$627.6K - Iron Chelators for Redox-Directed Cancer Cheomtherapy
Principal Investigator (PI)
2012
$143.2K
Technologies / Patents
News
- Chemistry Program Promotes Discovery-Based Experiences
2013
Publications (82)
Recent
- Targeting iron to contrast cancer progression
2023
- Multicenter interactions and ligand field effects in platinum II) tripyrrindione radicals
2023
- Solving world problems with pyrrole: 65th birthday tribute to Prof. Jonathan L. Sessler
2022
- Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 GLUT1) to Target Iron in Cancer Cells
2022
- Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators
2022
- Time-resolved dynamics of stable open-and closed-shell neutral radical and oxidized tripyrrindione complexes
2022
- Redox-activated pro-chelators
2022
- Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium(II) Dipyrrindione
2021
- Biopyrrin Pigments: From Heme Metabolites to Redox-Active Ligands and Luminescent Radicals
2021
- Iron chelator transmetalative approach to inhibit human ribonucleotide reductase
2021
- Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity ChemMedChem 18/2021)
2021
- Stabilization of a Triplet Diradical on a Binuclear palladium II) Dipyrrindione
2021
- Chemistry Discovery: A Service-Learning Outreach Course Produces a WorkshoSeries for Middle-School Students
2020
- The disturbed iron phenotype of tumor cells and macrophages in renal cell carcinoma influences tumor growth
2020
- Heteroleptic palladium II) complexes of dipyrrin-1, 9-dione supported by intramolecular hydrogen bonding
2020
- Iron Complexes of an Antiproliferative Aroyl Hydrazone: Characterization of Three Protonation States by Electron Paramagnetic Resonance Methods
2020
- Disulfide-masked pro-chelator compositions and methods of use
2020
- Ultrafast Dynamics of Tripyrrindiones in Solution Mediated by Hydrogen-Bonding Interactions
2019
- Propentdyopents: Brief history of a family of dipyrrolic pigments
2019
- Iron as a central player and promising target in cancer progression
2019
- Heteroleptic calladium II) complexes of the redox-active propentdyopent scaffold supported by intramolecular hydrogen bonding
2019
- Redox-Switchable Cyan Fluorescence of a BODIPY Analog Inspired by Propentdyopent Pigments
2019
- Disulfide-masked iron prochelators: Antiproliferative activity in breast cancer cells
2018
- Peptide‐Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real‐Time Detection of Lysine Deacylation
2018
- Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production
2018
- Paramagnetism and fluorescence of zinc II) tripyrrindione: A luminescent radical based on a redox-active biopyrrin
2018
- Elucidating the mechanism of action of titanium IV) complexes for a new anticancer drug design strategy
2018
- Redox-activated glycoconjugated prochelators
2018
- Ligand-based redox chemistry in transition metal complexes of linear oligopyrroles
2017
- Glycoconjugates of anti-proliferative iron prochelators
2017
- Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation
2017
- Ribonucleotide reductase enzyme a target for titanium complexes: A strategy to cure cancer
2017
- Interactions of metal-based and ligand-based electronic spins in neutral tripyrrindione π dimers
2017
- Cytotoxic titanium IV) compounds prepared with iron chelators alter the intracellular labile iron pool
2017
- Formation of radical anions on the dipyrrin-1, 9-dione scaffold of heme metabolites
2017
- Targeting iron in colon cancer via glycoconjugation of thiosemicarbazone prochelators
2016
- Coordination Chemistry of Linear Tripyrroles: Promises and Perils
2016
- Intracellular iron chelation modulates the macrophage iron phenotype with consequences on tumor progression
2016
- Disulfide-masked thiosemicarbazone prochelators targeting the iron metabolism of cancer
2016
- Radical stabilization and ligand-based redox chemistry on oligopyrrolic fragments
2016
- Propentdyopent: the scaffold of a heme metabolite as an electron reservoir in transition metal complexes
2016
- In-vitro and intracellular metal chelation properties of sirtuin inhibitor sirtinol
2016
- Metal-binding effects of sirtuin inhibitor sirtinol
2016
- Redox-directed chelators targeting intracellular metal ions
2016
- Redox chemistry of pyrrole-based ligands in transition metal complexes
2016
- Small pyrrole-based pigments as redox-active ligands
2016
- Tripyrrindione as a Redox-Active Ligand: Palladium(II) Coordination in Three Redox States
2015
- Linear oligopyrroles as redox-active ligands: Metal coordination and redox behavior
2015
- Overlaof protein inhibition and metal chelation: A case study
2015
- Sirtuin inhibitor sirtinol is an intracellular iron chelator
2015
- Metal binding effects of sirtuin inhibitor sirtinol
2015
- Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators
2014
- Coordination of first-row transition metals in biologically relevant oligopyrrolic fragments
2014
- Disulfide-masked thiosemicarbazone chelators for intracellular iron sequestration
2014
- Prodigiosin Analogue Designed for Metal Coordination: Stable Zinc and Copper Pyrrolyldipyrrins
2014
- Molecular strategies for intracellular iron sequestration
2014
- Redox-directed chelators targeting the altered iron metabolism of cancer cells
2013
- Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve
2013
- Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation
2013
- Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors
2011
- Developing ligands to target transition metals in cancer
2011
- Imaging mobile zinc in biology
2010
- Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging
2010
- Ratiometric and intensity-based zinc sensors built on rhodol and rhodamine platforms
2010
- INOR 312-Constructing, understanding, and utilizing fluorescent sensors for zinc in neurobiology
2008
- Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells
2008
- Binuclear organometallic ruthenium complexes of a Schiff base expanded porphyrin
2008
- Transition metal complexes of expanded porphyrins
2007
- Binuclear fluoro-bridged zinc and cadmium complexes of a schiff base expanded porphyrin: fluoride abstraction from the tetrafluoroborate anion
2007
- Copper ii) and oxovanadium v) complexes of hexaphyrin 1.0. 1.0. 0.0) Electronic supplementary information ESI) available: General experimental procedures and X-ray …
2007
- Copper(II) and oxovanadium(V) complexes of hexaphyrin(1.0.1.0.0.0)
2007
- Schiff base oligopyrrolic macrocycles as ligands for lanthanides and actinides
2006
- Coordination of oxovanadium(v) in an expanded porphyrin macrocycle
2006
- Positive homotropic allosteric binding of silver(I) cations in a Schiff base oligopyrrolic macrocycle
2006
- Calix[4]pyrrole Schiff base macrocycles: Novel binucleating ligands for Cu(I) and Cu(II)
2005
- Schiff base oligopyrrolic macrocycles as versatile binucleating ligands
2005
- A Schiff base expanded porphyrin macrocycle that acts as a versatile binucleating ligand for late first-row transition metals
2005
- Synthetic porphyrin- expanded porphyrin- dipyrrin- and pyrrole-containing motifs for molecular recognition
2004
- Coordination chemistry of expanded porphyrins: the synthesis of multinuclear metal complexes
2004
- Morphology of rhodium particles in ex-chloride Rh/Ce0. 5Zr0. 5O2 catalyst
2000
- Erratum-Volume 190, Number 1 2000) in the article Morphology of Rhodium Particles in Ex-chloride 486 Rh/Ce0. 5Zr0. 5O5 Catalyst. by G Vlaic, P Fornasiero, G Martra, E Fonda …
2000
- Morphology of rhodium particles in ex-chloride Rh/Ce0. 5Zr0. 5O2 catalyst vol 190, pg 182, 2000)
2000
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