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Photo of Elisa Tomat(tomat)

Elisa Tomat

Professor, Chemistry and Biochemistry,
Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
tomat@arizona.edu
520/626-5714
UAVitae logogoogle scholar logo
Grant: $5.0M
Professor Tomat is broadly interested in the role of transition metals, such as iron, copper and zinc, in human health and disease. A current focus of the Tomat research laboratory is on the involvement of iron in cancer growth. Motivated by the altered iron metabolism of cancer cells when compared to normal cells, we synthesize antiproliferative iron-binding compounds that are activated intracellularly and incorporate design elements to control redox chemistry, cellular uptake, and selectivity towards malignant cells. We are also examining the impact of iron chelators on macrophages and the implication of these immune cells in iron distribution within the tumor microenvironment.
Elisa Tomat experts in inorganic chemistry, bioinorganic chemistry, organometallic chemistry, organic chemistry, chemistry, pharmacology, biochemistry, molecular biology, bioinformatics, computational biology, cancer biology, biomaterials, drug delivery, medicinal chemistry, heterogeneous catalysis, catalysis, supramolecular chemistry, neuroscience, biosensors, biomedical engineering, fluorescence spectroscopy, biophysics, materials science, surface science, machine learning, olfaction, organometallics, chemical biology, drug metabolism, condensed matter physics, ultrafast spectroscopy, chemistry education research, nuclear physics, astrophysics
Courses
Inorganic Preparation 
Honors Fundamentals of Chemistry 
Inorganic Preparations 
Advanced Inorganic Chemistry 
Recent Grants
Logo of Redox-Active Biopyrrin Pigments in Supramolecular Radical Assemblies funding agency
2022 $481.4KActive
Redox-Active Biopyrrin Pigments in Supramolecular Radical Assemblies
Logo of MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education funding agency
2021 $266.2KActive
MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education
Logo of Selective Killing of FH-/- Cancer Cells by Targeting Cellular Iron Homeostasis funding agency
2018 $1.6MActive
Selective Killing of FH-/- Cancer Cells by Targeting Cellular Iron Homeostasis
Logo of Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy funding agency
2018 $1.2MActive
Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy
Logo of Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy funding agency
2018 $31.9KActive
Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy
Logo of Elucidating the Orchestrated Bacterial Response to Copper Toxicity - Diversity Supplement (UGrad) funding agency
2018 $13.0KActive
Elucidating the Orchestrated Bacterial Response to Copper Toxicity - Diversity Supplement (UGrad)
Logo of Copper Chelating Compounds as Novel Antimicrobial Class funding agency
2021 $82.0K
Copper Chelating Compounds as Novel Antimicrobial Class
Logo of MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona funding agency
2019 $500.8K
MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona
Logo of CAREER: Interplay of Metal Coordination and Ligand-Based Reactivity in Complexes of Oligopyrrolic Fragments funding agency
2015 $627.6K
CAREER: Interplay of Metal Coordination and Ligand-Based Reactivity in Complexes of Oligopyrrolic Fragments
Logo of Iron Chelators for Redox-Directed Cancer Cheomtherapy funding agency
2012 $143.2K
Iron Chelators for Redox-Directed Cancer Cheomtherapy
Technologies / Patents
Logo of Redox-Activated Pro-Chelators
2022Redox-Activated Pro-Chelators 
Logo of Redox-Directed Chelators Targeting Intracellular Metal Ions
2016Redox-Directed Chelators Targeting Intracellular Metal Ions 
Logo of Glycoconjugates of Anti-Proliferative Iron Prochelators
1899Glycoconjugates of Anti-Proliferative Iron Prochelators 
News
2013Chemistry Program Promotes Discovery-Based Experiences 
Publications (83)
Recent
2022Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells 
2022Time-resolved dynamics of stable open-and closed-shell neutral radical and oxidized tripyrrindione complexes 
2022Solving world problems with pyrrole: 65th birthday tribute to Prof. Jonathan L. Sessler 
2022Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators 
2022Redox-activated pro-chelators 
2021Iron chelator transmetalative approach to inhibit human ribonucleotide reductase 
2021Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021) 
2021Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity 
2021Biopyrrin Pigments: From Heme Metabolites to Redox-Active Ligands and Luminescent Radicals 
2021Stabilization of a Triplet Diradical on a Binuclear palladium (II) Dipyrrindione 
2021Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium (II) Dipyrrindione 
2020Heteroleptic palladium (II) complexes of dipyrrin-1, 9-dione supported by intramolecular hydrogen bonding 
2020Iron Complexes of an Antiproliferative Aroyl Hydrazone: Characterization of Three Protonation States by Electron Paramagnetic Resonance Methods 
2020Disulfide-masked pro-chelator compositions and methods of use 
2020The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth 
2020Chemistry Discovery: A Service-Learning Outreach Course Produces a Workshop Series for Middle-School Students 
2019Heteroleptic calladium (II) complexes of the redox-active propentdyopent scaffold supported by intramolecular hydrogen bonding 
2019Iron as a central player and promising target in cancer progression 
2019Propentdyopents: Brief history of a family of dipyrrolic pigments 
2019Ultrafast Dynamics of Tripyrrindiones in Solution Mediated by Hydrogen-Bonding Interactions 
2019Redox‐Switchable Cyan Fluorescence of a BODIPY Analog Inspired by Propentdyopent Pigments 
2018Paramagnetism and fluorescence of zinc (II) tripyrrindione: A luminescent radical based on a redox-active biopyrrin 
2018Disulfide-masked iron prochelators: Antiproliferative activity in breast cancer cells 
2018Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production 
2018Redox-activated glycoconjugated prochelators 
2018Peptide‐Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real‐Time Detection of Lysine Deacylation 
2018Elucidating the mechanism of action of titanium (IV) complexes for a new anticancer drug design strategy 
2018Paramagnetism and Fluorescence of Zinc(II) Tripyrrindione: A Luminescent Radical Based on a Redox-Active Biopyrrin 
2017Cytotoxic titanium (IV) compounds prepared with iron chelators alter the intracellular labile iron pool 
2017Interactions of Metal-Based and Ligand-Based Electronic Spins in Neutral Tripyrrindione π Dimers 
2017Ribonucleotide reductase enzyme a target for titanium complexes: A strategy to cure cancer 
2017Formation of radical anions on the dipyrrin-1, 9-dione scaffold of heme metabolites 
2017Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation 
2017Ligand-based redox chemistry in transition metal complexes of linear oligopyrroles 
2017Glycoconjugates of anti-proliferative iron prochelators 
2016In-vitro and intracellular metal chelation properties of sirtuin inhibitor sirtinol 
2016Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression 
2016Coordination chemistry of linear tripyrroles: promises and perils 
2016Radical stabilization and ligand-based redox chemistry on oligopyrrolic fragments 
2016Redox chemistry of pyrrole-based ligands in transition metal complexes 
2016Propentdyopent: the scaffold of a heme metabolite as an electron reservoir in transition metal complexes 
2016Redox-directed chelators targeting intracellular metal ions 
2016Targeting iron in colon cancer via glycoconjugation of thiosemicarbazone prochelators 
2016Metal-binding effects of sirtuin inhibitor sirtinol 
2016Small pyrrole-based pigments as redox-active ligands 
2016Disulfide-masked thiosemicarbazone prochelators targeting the iron metabolism of cancer 
2015Linear oligopyrroles as redox-active ligands: Metal coordination and redox behavior 
2015Metal binding effects of sirtuin inhibitor sirtinol 
2015Sirtuin inhibitor sirtinol is an intracellular iron chelator 
2015Overlap of protein inhibition and metal chelation: A case study 
2015Tripyrrindione as a Redox-Active Ligand: Palladium(II) Coordination in Three Redox States 
2014Prodigiosin Analogue Designed for Metal Coordination: Stable Zinc and Copper Pyrrolyldipyrrins 
2014Coordination of first-row transition metals in biologically relevant oligopyrrolic fragments 
2014Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators 
2014Molecular strategies for intracellular iron sequestration 
2014Disulfide-masked thiosemicarbazone chelators for intracellular iron sequestration 
2013Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve 
2013Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation 
2013Redox-directed chelators targeting the altered iron metabolism of cancer cells 
2011Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors 
2011Developing ligands to target transition metals in cancer 
2010Ratiometric and intensity-based zinc sensors built on rhodol and rhodamine platforms 
2010Imaging mobile zinc in biology 
2010Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging 
2008INOR 312-Constructing, understanding, and utilizing fluorescent sensors for zinc in neurobiology 
2008Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells 
2008Binuclear organometallic ruthenium complexes of a Schiff base expanded porphyrin 
2007Binuclear fluoro-bridged zinc and cadmium complexes of a schiff base expanded porphyrin: fluoride abstraction from the tetrafluoroborate anion 
2007Copper(II) and oxovanadium(V) complexes of hexaphyrin(1.0.1.0.0.0) 
2007Copper (ii) and oxovanadium (v) complexes of hexaphyrin (1.0. 1.0. 0.0) Electronic supplementary information (ESI) available: General experimental procedures and X-ray … 
2007Transition-metal complexes of expanded porphyrins 
2006POSTER PRESENTATIONS-Positive homotropic allosteric binding of silver (I) cations in a Schiff base oligopyrrolic macrocycle 
2006Schiff base oligopyrrolic macrocycles as ligands for lanthanides and actinides 
2006Coordination of oxovanadium(v) in an expanded porphyrin macrocycle 
2006Positive homotropic allosteric binding of silver (I) cations in a Schiff base oligopyrrolic macrocycle 
2005A Schiff base expanded porphyrin macrocycle that acts as a versatile binucleating ligand for late first-row transition metals 
2005Calix [4] pyrrole Schiff base macrocycles: novel binucleating ligands for Cu (I) and Cu (II) 
2005Schiff base oligopyrrolic macrocycles as versatile binucleating ligands 
2004Synthetic porphyrin-, expanded porphyrin-, dipyrrin-, and pyrrole-containing motifs for molecular recognition 
2004Coordination chemistry of expanded porphyrins: the synthesis of multinuclear metal complexes 
2000Morphology of rhodium particles in ex-chloride Rh/Ce0. 5Zr0. 5O2 catalyst 
2000Erratum-Volume 190, Number 1 (2000), in the article Morphology of Rhodium Particles in Ex-chloride 486 Rh/Ce0. 5Zr0. 5O5 Catalyst. by G Vlaic, P Fornasiero, G Martra, E Fonda … 
2000Morphology of rhodium particles in ex-chloride Rh/Ce0. 5Zr0. 5O2 catalyst (vol 190, pg 182, 2000) 
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