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Elisa Tomat
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Professor Tomat is broadly interested in the role of transition metals, such as iron, copper and zinc, in human health and disease. A current focus of the Tomat research laboratory is on the involvement of iron in cancer growth. Motivated by the altered iron metabolism of cancer cells when compared to normal cells, we synthesize antiproliferative iron-binding compounds that are activated intracellularly and incorporate design elements to control redox chemistry, cellular uptake, and selectivity towards malignant cells. We are also examining the impact of iron chelators on macrophages and the implication of these immune cells in iron distribution within the tumor microenvironment.Show Less
Courses
Inorganic Preparation |
Honors Fundamentals of Chemistry |
Inorganic Preparations |
Advanced Inorganic Chemistry |
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Technologies / Patents
![]() | 2022 | Redox-Activated Pro-Chelators |
![]() | 2016 | Redox-Directed Chelators Targeting Intracellular Metal Ions |
![]() | 1899 | Glycoconjugates of Anti-Proliferative Iron Prochelators |
News
2013 | Chemistry Program Promotes Discovery-Based Experiences |
Publications (83)
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