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Elisa Tomat

Professor, Chemistry and Biochemistry,

Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
tomat@arizona.edu

520/626-5714

Grant: $5.0M

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Professor Tomat is broadly interested in the role of transition metals, such as iron, copper and zinc, in human health and disease. A current focus of the Tomat research laboratory is on the involvement of iron in cancer growth. Motivated by the altered iron metabolism of cancer cells when compared to normal cells, we synthesize antiproliferative iron-binding compounds that are activated intracellularly and incorporate design elements to control redox chemistry, cellular uptake, and selectivity towards malignant cells. We are also examining the impact of iron chelators on macrophages and the implication of these immune cells in iron distribution within the tumor microenvironment.

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Elisa Tomat experts in inorganic chemistry, bioinorganic chemistry, organometallic chemistry, organic chemistry, chemistry, pharmacology, biochemistry, molecular biology, bioinformatics, computational biology, cancer biology, biomaterials, drug delivery, medicinal chemistry, heterogeneous catalysis, catalysis, supramolecular chemistry, neuroscience, biosensors, biomedical engineering, fluorescence spectroscopy, biophysics, materials science, surface science, machine learning, olfaction, organometallics, chemical biology, drug metabolism, condensed matter physics, ultrafast spectroscopy, chemistry education research, nuclear physics, astrophysics

Courses

Inorganic Preparation

Honors Fundamentals of Chemistry

Inorganic Preparations

Advanced Inorganic Chemistry

Recent Grants

	2022	$481.4K	Active
Redox-Active Biopyrrin Pigments in Supramolecular Radical Assemblies
$Logo of MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education funding agency$	2021	$266.2K	Active
MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education
	2018	$1.6M	Active
Selective Killing of FH-/- Cancer Cells by Targeting Cellular Iron Homeostasis
	2018	$1.2M	Active
Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy
	2018	$31.9K	Active
Molecular Strategies to Examine and Exploit the Role of Iron in Cell Proliferation and Malignancy
	2018	$13.0K	Active
Elucidating the Orchestrated Bacterial Response to Copper Toxicity - Diversity Supplement (UGrad)
	2021	$82.0K
Copper Chelating Compounds as Novel Antimicrobial Class
	2019	$500.8K
MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona
	2015	$627.6K
CAREER: Interplay of Metal Coordination and Ligand-Based Reactivity in Complexes of Oligopyrrolic Fragments
	2012	$143.2K
Iron Chelators for Redox-Directed Cancer Cheomtherapy

Technologies / Patents

	2022	Redox-Activated Pro-Chelators
	2016	Redox-Directed Chelators Targeting Intracellular Metal Ions
	1899	Glycoconjugates of Anti-Proliferative Iron Prochelators

News

2013	Chemistry Program Promotes Discovery-Based Experiences

Publications (83)

Recent

2022	Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells
2022	Time-resolved dynamics of stable open-and closed-shell neutral radical and oxidized tripyrrindione complexes
2022	Solving world problems with pyrrole: 65th birthday tribute to Prof. Jonathan L. Sessler
2022	Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators
2022	Redox-activated pro-chelators
2021	Iron chelator transmetalative approach to inhibit human ribonucleotide reductase
2021	Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021)
2021	Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity
2021	Biopyrrin Pigments: From Heme Metabolites to Redox-Active Ligands and Luminescent Radicals
2021	Stabilization of a Triplet Diradical on a Binuclear palladium (II) Dipyrrindione
2021	Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium (II) Dipyrrindione
2020	Heteroleptic palladium (II) complexes of dipyrrin-1, 9-dione supported by intramolecular hydrogen bonding
2020	Iron Complexes of an Antiproliferative Aroyl Hydrazone: Characterization of Three Protonation States by Electron Paramagnetic Resonance Methods
2020	Disulfide-masked pro-chelator compositions and methods of use
2020	The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth
2020	Chemistry Discovery: A Service-Learning Outreach Course Produces a Workshop Series for Middle-School Students
2019	Heteroleptic calladium (II) complexes of the redox-active propentdyopent scaffold supported by intramolecular hydrogen bonding
2019	Iron as a central player and promising target in cancer progression
2019	Propentdyopents: Brief history of a family of dipyrrolic pigments
2019	Ultrafast Dynamics of Tripyrrindiones in Solution Mediated by Hydrogen-Bonding Interactions
2019	Redox‐Switchable Cyan Fluorescence of a BODIPY Analog Inspired by Propentdyopent Pigments
2018	Paramagnetism and fluorescence of zinc (II) tripyrrindione: A luminescent radical based on a redox-active biopyrrin
2018	Disulfide-masked iron prochelators: Antiproliferative activity in breast cancer cells
2018	Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production
2018	Redox-activated glycoconjugated prochelators
2018	Peptide‐Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real‐Time Detection of Lysine Deacylation
2018	Elucidating the mechanism of action of titanium (IV) complexes for a new anticancer drug design strategy
2018	Paramagnetism and Fluorescence of Zinc(II) Tripyrrindione: A Luminescent Radical Based on a Redox-Active Biopyrrin
2017	Cytotoxic titanium (IV) compounds prepared with iron chelators alter the intracellular labile iron pool
2017	Interactions of Metal-Based and Ligand-Based Electronic Spins in Neutral Tripyrrindione π Dimers
2017	Ribonucleotide reductase enzyme a target for titanium complexes: A strategy to cure cancer
2017	Formation of radical anions on the dipyrrin-1, 9-dione scaffold of heme metabolites
2017	Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation
2017	Ligand-based redox chemistry in transition metal complexes of linear oligopyrroles
2017	Glycoconjugates of anti-proliferative iron prochelators
2016	In-vitro and intracellular metal chelation properties of sirtuin inhibitor sirtinol
2016	Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression
2016	Coordination chemistry of linear tripyrroles: promises and perils
2016	Radical stabilization and ligand-based redox chemistry on oligopyrrolic fragments
2016	Redox chemistry of pyrrole-based ligands in transition metal complexes
2016	Propentdyopent: the scaffold of a heme metabolite as an electron reservoir in transition metal complexes
2016	Redox-directed chelators targeting intracellular metal ions
2016	Targeting iron in colon cancer via glycoconjugation of thiosemicarbazone prochelators
2016	Metal-binding effects of sirtuin inhibitor sirtinol
2016	Small pyrrole-based pigments as redox-active ligands
2016	Disulfide-masked thiosemicarbazone prochelators targeting the iron metabolism of cancer
2015	Linear oligopyrroles as redox-active ligands: Metal coordination and redox behavior
2015	Metal binding effects of sirtuin inhibitor sirtinol
2015	Sirtuin inhibitor sirtinol is an intracellular iron chelator
2015	Overlap of protein inhibition and metal chelation: A case study
2015	Tripyrrindione as a Redox-Active Ligand: Palladium(II) Coordination in Three Redox States
2014	Prodigiosin Analogue Designed for Metal Coordination: Stable Zinc and Copper Pyrrolyldipyrrins
2014	Coordination of first-row transition metals in biologically relevant oligopyrrolic fragments
2014	Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators
2014	Molecular strategies for intracellular iron sequestration
2014	Disulfide-masked thiosemicarbazone chelators for intracellular iron sequestration
2013	Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve
2013	Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation
2013	Redox-directed chelators targeting the altered iron metabolism of cancer cells
2011	Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors
2011	Developing ligands to target transition metals in cancer
2010	Ratiometric and intensity-based zinc sensors built on rhodol and rhodamine platforms
2010	Imaging mobile zinc in biology
2010	Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging
2008	INOR 312-Constructing, understanding, and utilizing fluorescent sensors for zinc in neurobiology
2008	Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells
2008	Binuclear organometallic ruthenium complexes of a Schiff base expanded porphyrin
2007	Binuclear fluoro-bridged zinc and cadmium complexes of a schiff base expanded porphyrin: fluoride abstraction from the tetrafluoroborate anion
2007	Copper(II) and oxovanadium(V) complexes of hexaphyrin(1.0.1.0.0.0)
2007	Copper (ii) and oxovanadium (v) complexes of hexaphyrin (1.0. 1.0. 0.0) Electronic supplementary information (ESI) available: General experimental procedures and X-ray …
2007	Transition-metal complexes of expanded porphyrins
2006	POSTER PRESENTATIONS-Positive homotropic allosteric binding of silver (I) cations in a Schiff base oligopyrrolic macrocycle
2006	Schiff base oligopyrrolic macrocycles as ligands for lanthanides and actinides
2006	Coordination of oxovanadium(v) in an expanded porphyrin macrocycle
2006	Positive homotropic allosteric binding of silver (I) cations in a Schiff base oligopyrrolic macrocycle
2005	A Schiff base expanded porphyrin macrocycle that acts as a versatile binucleating ligand for late first-row transition metals
2005	Calix [4] pyrrole Schiff base macrocycles: novel binucleating ligands for Cu (I) and Cu (II)
2005	Schiff base oligopyrrolic macrocycles as versatile binucleating ligands
2004	Synthetic porphyrin-, expanded porphyrin-, dipyrrin-, and pyrrole-containing motifs for molecular recognition
2004	Coordination chemistry of expanded porphyrins: the synthesis of multinuclear metal complexes
2000	Morphology of rhodium particles in ex-chloride Rh/Ce0. 5Zr0. 5O2 catalyst
2000	Erratum-Volume 190, Number 1 (2000), in the article Morphology of Rhodium Particles in Ex-chloride 486 Rh/Ce0. 5Zr0. 5O5 Catalyst. by G Vlaic, P Fornasiero, G Martra, E Fonda …
2000	Morphology of rhodium particles in ex-chloride Rh/Ce0. 5Zr0. 5O2 catalyst (vol 190, pg 182, 2000)

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