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Picture of George Sutphin

George Sutphin

Assistant Professor, Molecular and Cellular Biology | Assistant Professor, Innovations in Aging - GIDP | Assistant Professor, BIO5 Institute | Assistant Professor | Assistant Professor, Genetics - GIDP | Assistant Professor, Cancer Biology - GIDP | Member of the Graduate Faculty

Molecular and Cellular Biology

Collaboration(20)

Baldassarre Stea
Megha Padi
Yana Zavros
Kristian Doyle
Ross Buchan

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Grants(6)

Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training Program
Active·2024·$0 / $292.3K·
External
Key Personnel (KP)
aging, infection, inflammation, pre-doctoral, training
An Automated High-Content Imaging Platform for Caenorhabditis Elegans
Active·2023·$989.9K / $1.3M·
External
Principal Investigator (PI)
high-content imaging, automated platform, caenorhabditis elegans, imaging, automation
Defining the Genetic Architecture of Multi-Stress Response
Active·2019·$2.1M·
External
Principal Investigator (PI)
genetic, stress response, multi-stress, genetic architecture, response
Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty
Active·2019·$98.5K·
External
Principal Investigator (PI)
aging research, medical research, grant funding, junior faculty support, healthcare innovation
Targeting De Novo NAD+ Synthesis Through the Kynurenine Pathway in Renal Cell Carcinoma
2021·$150.3K·
External
Principal Investigator (PI)
cancer, metabolism, renal cell carcinoma, nad+ synthesis, kynurenine pathway

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Publications(93)

Recent

3-Hydroxyanthranilic Acid Delays Paralysis in Caenorhabditis elegans Models of Amyloid-Beta and Polyglutamine Proteotoxicity

2024

neurodegenerative diseases, drug development, proteotoxicity, amino acid metabolism, model organisms

Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function

2024

genetics, cardiovascular, adipose tissue, mutation, animal model

The Emerging Role of 3-Hydroxyanthranilic Acid on C. elegans Aging Immune Function

2024

aging, immune function, c. elegans

3-Hydroxyanthranilic Acid Delays Paralysis in

2024

neurodegenerative diseases, drug development, metabolism, oxidative stress, inflammation

Experimental variables that impact outcomes in Caenorhabditis elegans aging stress response

2024

aging, stress response, caenorhabditis elegans, outcomes

Fmo induction as a tool to screen for pro-longevity drugs

2024

aging, biomedical research, drug discovery, cellular pathways

RAB27A knockout extends lifein C. elegans but not mice

2023

aging, genetics, model organisms, cell biology, species comparison

Global Rab27a null mutation alters the vascular microenvironment proteome and regulates vasoreactivity in mice

2023

genetic mutation, vascular biology, proteomics, vasoreactivity, mice model

3-hydroxyanthranilic acid promotes immune system resilience in aging Caenorhabditis elegans

2023

immunology, aging, resilience, metabolism, model organism

3-hydroxyanthranilic acid – a new metabolite for healthy lifeextension

2023

metabolism, life extension, health, nutrition, biochemistry