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Profile
Melissa Lynn
Researcher/Scientist III
Biomedical Engineering
Full Page
Overview
Research
More
Collaboration
(4)
Steven Schwartz
Mutual work: 1 Proposal
Collaboration Details
Brett Colson
Mutual work: 1 Proposal
Collaboration Details
Jil Tardiff
Mutual work: 1 Grant﹒4 Proposals﹒1 Supervisor
Collaboration Details
Priscilla Jayassi
Mutual work: 1 Proposal
Collaboration Details
Publications
(24)
Recent
The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation
2023
genetics,
cardiology,
protein structure,
myofilament dynamics,
allosteric regulation
Structure and dynamics of the flexible cardiac troponin T linker domain in a fully reconstituted thin filament
2022
protein dynamics,
cardiac physiology,
muscle proteins,
biomolecular structure,
filament dynamics
Strucutrally defining the flexible cardiac troponin T linker
2022
cardiac troponin t,
protein structure,
cardiac muscle,
biomolecular structure,
muscle physiology
Calcium Dissociation of HCM Causative R21C Troponin I Mutation
2021
calcium regulation,
cardiomyopathy,
mutation analysis,
troponin,
genetic research
Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament
2021
genetic variants,
cardiac health,
biophysical modeling,
pathogenicity,
computational analysis
Intrinsic Modifier Effect of cTnT Isoform Switching in Sarcomeric Cardiomyopathies
2020
cardiomyopathies,
ctnt isoform,
sarcomeric,
modifier effect,
intrinsic
The Mechanistic Role of Tropomyosin OverlaDysregulation in Early Cardiomyopathic Disease Progression
2019
cardiomyopathy,
tropomyosin,
disease progression,
mechanistic role,
early stage
FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation
2019
cardiac troponin t,
hypertrophic cardiomyopathy,
fret-based analysis,
structural basis,
linker region
Multi-Timepoint RNA-Sequencing Reveals Differential Gene Expression of Transgenic Mouse Models of Hypertrophic and Dilated Cardiomyopathies
2019
gene expression,
cardiomyopathies,
rna sequencing,
transgenic mouse models,
differential expression
Proof of principle that molecular modeling followed by a biophysical experiment can develosmall molecules that restore function to the cardiac thin filament in the presence …
2019
molecular modeling,
biophysical experiment,
cardiac thin filament,
small molecules,
restoring function
