Photo of Roger Miesfeld(rlm)

Roger Miesfeld

Member of the Graduate Faculty,
Professor, Molecular and Cellular Biology,
Professor, BIO5 Institute,
Professor, Entomology / Insect Science - GIDP,
Distinguished Professor, Chemistry and Biochemistry,
Professor, Chemistry and Biochemistry,

Chemistry & Biochemistry - Sci
UAVitae logogoogle scholar logoOrcid logo
Grant: $4.0M
Roger L. Miesfeld, Ph.D., Professor and Co-Chair, Dept. of Chemistry & Biochemistry, College of Science, University of Arizona. Mosquitoes are human disease vectors that transmit pathogens through blood feeding. One of these disease vectors is the Aedes aegypti mosquito, which have rapidly expanded their habitat and are contributing annually to 500,000 cases of Dengue hemorrhagic fever. On an even greater scale, Anopheline mosquitoes account for 250 million cases of malaria/yr, with up to 1 million deaths annually. The most common adult insecticides used for mosquito control are pyrethroids, which inhibit evolutionarily conserved sodium channels in the mosquito nervous system. Although these compounds have proven to be effective, mosquito resistance is an increasing problem and there is a pressing need to develop the next generation of safe and effective agents. Since blood meal feeding creates a unique metabolic challenge as a result of the extremely high protein and iron content of blood, it is possible that interfering with blood meal metabolism could provide a novel control strategy for mosquito born diseases. Our long term goal is to identify small molecule inhibitors that block blood meal metabolism in vector mosquitoes, resulting in feeding-induced death of the adult female, or a significant reduction in egg viability, as a strategy to control vector mosquito populations in areas of high disease transmission.
Roger Miesfeld experts in bioinformatics, molecular biology, genomics, pharmacology, biochemistry, computational biology, neuroscience, entomology, urologic oncology, cell biology, molecular parasitology, cancer biology, apoptosis, eosinophils, mass spectrometry, proteomics, metabolomics, virology, structural biology, systems biology, dna repair, bronchopulmonary dysplasia, prostate cancer, endocrinology, molecular ecology, evolutionary biology, microbiology, microbial ecology, insecticide resistance, parasitology
Introduction to Biochemical Research 
General Protein and General Metabolic Biochemistry 
Foundations in Biochemistry 
Metabolic Biochemistry 
Recent Grants
Logo of Graduate Student Internships at Luceome Biotechnologies funding agency
2011 $718.0K
Graduate Student Internships at Luceome Biotechnologies
Logo of Regulation of Digestion in Blood-Sucking Insects funding agency
2006 $1.6M
Regulation of Digestion in Blood-Sucking Insects
Logo of Regulation of Energy Metabolism in Insects funding agency
2006 $1.6M
Regulation of Energy Metabolism in Insects
Technologies / Patents
Logo of Tricyclic Mosquitocides and Methods of Making and Using Thereof
2019Tricyclic Mosquitocides and Methods of Making and Using Thereof 
Logo of Tricyclic Mosquitocides and Methods of Making and Using Thereof
1899Tricyclic Mosquitocides and Methods of Making and Using Thereof 
Logo of Compositions And Methods For Modulating Egg Development In Mosquitoes
1899Compositions And Methods For Modulating Egg Development In Mosquitoes 
2021Biochemistry, 2nd Edition 
2017Biochemistry, 1st Edition 
1999Applied Molecular Genetics 
1997Biochemistry: A Short Course 
2021Outstanding Graduates Will Be Honored for Service, Academics and Perseverance 
2019Fighting Human Disease with Birth Control… for Mosquitoes 
2018I-Squared Awards Honor Inventors, Entrepreneurs, Ecosystem Champions 
2017UA Online: All This, and Science Too 
2011Making Blood-Sucking Deadly for Mosquitoes 
2008Researchers Put the Bite on Mosquitoes 
2008The Force Behind 'WaveLengths' 
2008Arizona Public Media Launches New Series 
2002Faculty Senate Election Leaves Seats Unfilled 
Publications (64)
2019Identification and characterization of a mosquito-specific eggshell organizing factor in Aedes aegypti mosquitoes 
2013COPI-mediated blood meal digestion in vector mosquitoes is independent of midgut ARF-GEF and ARF-GAP regulatory activities 
2012Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes 
2011Deficiencies in acetyl-CoA carboxylase and fatty acid synthase 1 differentially affect eggshell formation and blood meal digestion in Aedes aegypti 
2011Defects in coatomer protein I (COPI) transport cause blood feeding-induced mortality in Yellow Fever mosquitoes 
2011Alpha-COPI coatomer protein is required for rough endoplasmic reticulum whorl formation in mosquito midgut epithelial cells 
2011In vitro activation and enzyme kinetic analysis of recombinant midgut serine proteases from the Dengue vector mosquito Aedes aegypti 
2010Differentiation and quantification of C1 and C2 (13)C-labeled glucose by tandem mass spectrometry 
2010Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti 
2010Differential ammonia metabolism in Aedes aegypti fat body and midgut tissues 
2010Differentiation and quantification of C1 and C2 sup 13 /sup C-labeled glucose by tandem mass spectrometry 
2009Energy metabolism during diapause in Culex pipiens mosquitoes 
2009Molecular analysis of the Aedes aegypti carboxypeptidase gene family 
2009Molecular genetic analysis of midgut serine proteases in Aedes aegypti mosquitoes 
2008Discovery of an alternate metabolic pathway for urea synthesis in adult Aedes aegypti mosquitoes 
2008TOR signaling is required for amino acid stimulation of early trypsin protein synthesis in the midgut of Aedes aegypti mosquitoes 
2007Cloning and characterization of a novel MyoD enhancer-binding factor 
2007Regulated expression of microinjected DNA in adult Aedes aegypti mosquitoes 
2006Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression 
2006Increased expression of the metastasis-associated gene Ehm2 in prostate cancer 
2004Differential control of eosinophil survival by glucocorticoids 
2004Androgen control of cell proliferation and cytoskeletal reorganization in human fibrosarcoma cells: role of RhoB signaling 
2003Identification of a Novel Glucocorticoid Receptor Mutation in Budesonide-Resistant Human Bronchial Epithelial Cells 
2003Glucocorticoid regulation of human eosinophil gene expression 
2003Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation 
2002Androgen induction of in vitro prostate cell differentiation 
2001Analysis of glucocorticoid and androgen receptor gene fusions delineates domains required for transcriptional specificity 
1999Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis 
1998Glucocorticoid regulation of GM-CSF: evidence for transcriptional mechanisms in airway epithelial cells 
1997Glucocorticoid receptor signaling in a bronchial epithelial cell line 
1997Crosstalk during Ca2+-, cAMP-, and glucocorticoid-induced gene expression in lymphocytes 
1996Transcriptional control of steroid-regulated apoptosis in murine thymoma cells 
1996Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain 
1995Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: the effect of sulindac 
1995A cell-specific and selective effect on transactivation by the androgen receptor 
1995Isolation of differentially expressed sequence tags from steroid-responsive cells using mRNA differential display 
1995Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation 
1994The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function 
1994Recessive mutations in a common pathway block thymocyte apoptosis induced by multiple signals 
1994Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca sup 2+ /sup fluxes 
1993Elevated glutathione S-transferase gene expression is an early event during steroid-induced lymphocyte apoptosis 
1992Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes 
1992Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis 
1992Characterization of a panel of rat ventral prostate epithelial cell lines immortalized in the presence or absence of androgens 
1992Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events 
1991Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate 
1990nt sup i /sup glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain 
1990Transcriptional analyses of steroid-regulated gene networks 
1990Molecular genetics of corticosteroid action 
1990Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation 
1989The structure and function of steroid receptor proteins 
1988Mechanism of glucocorticoid receptor down-regulation by glucocorticoids 
1987Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. 
1987Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement 
1987Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation 
1987Characterization of glucocorticoid receptors and glucocorticoid receptor mRNA in human leukemia cells: Stabilization of the receptor by diisopropylfluorophosphate 
1986Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA 
1984Species-specific rDNA transcription is due to promoter-specific binding factors 
1984The absence of a human-specific ribosomal DNA transcription factor leads to nucleolar dominance in mouse human hybrid cells 
1984Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells 
1982Identification of the in vivo and in vitro origin of transcription in human rDNA 
1981Studies on the nature and germ-line stability of DNA sequences flanking the mouse immunoglobulin heavy-chain constant-region genes 
1981A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human δ and β globin genes 
1980Mouse rDNA nontranscribed spacer sequences are found flanking immunoglobulin CH genes and elsewhere throughout the genome