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Roger Miesfeld
Member of the Graduate Faculty,
Professor, Molecular and Cellular Biology,
Professor, BIO5 Institute,
Professor, Entomology / Insect Science - GIDP,
Distinguished Professor, Chemistry and Biochemistry,
Professor, Chemistry and Biochemistry,
Chemistry & Biochemistry - Sci
rlm@arizona.edu
520/626-1925
Grant: $4.0M❝
Roger L. Miesfeld, Ph.D., Professor and Co-Chair, Dept. of Chemistry & Biochemistry, College of Science, University of Arizona. Mosquitoes are human disease vectors that transmit pathogens through blood feeding. One of these disease vectors is the Aedes aegypti mosquito, which have rapidly expanded their habitat and are contributing annually to 500,000 cases of Dengue hemorrhagic fever. On an even greater scale, Anopheline mosquitoes account for 250 million cases of malaria/yr, with up to 1 million deaths annually. The most common adult insecticides used for mosquito control are pyrethroids, which inhibit evolutionarily conserved sodium channels in the mosquito nervous system. Although these compounds have proven to be effective, mosquito resistance is an increasing problem and there is a pressing need to develop the next generation of safe and effective agents. Since blood meal feeding creates a unique metabolic challenge as a result of the extremely high protein and iron content of blood, it is possible that interfering with blood meal metabolism could provide a novel control strategy for mosquito born diseases. Our long term goal is to identify small molecule inhibitors that block blood meal metabolism in vector mosquitoes, resulting in feeding-induced death of the adult female, or a significant reduction in egg viability, as a strategy to control vector mosquito populations in areas of high disease transmission.Show Less
Courses
Introduction to Biochemical Research |
General Protein and General Metabolic Biochemistry |
Biochemistry |
Foundations in Biochemistry |
Metabolic Biochemistry |
Recent Grants
2011 | $718.0K | |||
Graduate Student Internships at Luceome Biotechnologies | ||||
2006 | $1.6M | |||
Regulation of Digestion in Blood-Sucking Insects | ||||
2006 | $1.6M | |||
Regulation of Energy Metabolism in Insects |
Technologies / Patents
Books
2021 | Biochemistry, 2nd Edition |
2017 | Biochemistry, 1st Edition |
1999 | Applied Molecular Genetics |
1997 | Biochemistry: A Short Course |
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Publications (64)
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