KMap
- CHRChemical Hygiene and Regulations
- BLSBasic Laboratory Safety
- LOCLectures in Organic Chemistry
- SMOSynthetic and Mechanistic Organic Chemistry
- OPOrganic Preparations
- ALSAdvanced Laboratory Safety
- IPTIntroduction to Pharmacology and Toxicology Research
- AOCAdvanced Organic Chemistry
- ASOAdvanced Synthetic Organic Chemistry
- IPDIntroduction to Pharmacology, Drug Discovery & Pharmaceutics
- Development of Immune Modulators Targeting Autoimmune Disorders and Pulmonary Injury: Design, Synthesis, and Biological Evaluation of Sphingolipid-Derived Sphingosine-1 Phosphate Receptor 1 Agonists
2022
doctoral - Synthesis, Comprehensive Characterization, and Development of Therapeutic Peptides and Glycopeptides for Targeted Respiratory Drug Delivery as Inhalation Aerosols
2021
doctoral - Design, Synthesis, and Evaluation of Brain-Penetrant PACAP-Derived Glycopeptides for the Treatment of Neurodegeneration and Neuroinflammation
2021
doctoral - Synthesis and Characterization of Bio-inspired Glycolipid Surfactants
2018
doctoral - Creating a C-12 Series of Glycolipids for Use as Micelles in Drug Delivery
2017
bachelors - Design and Synthesis of Neurologically Active Glycopeptides for Neuroprotection and Antinociception
2016
doctoral - Design and Synthesis of PACAP Based Glycopeptide Analogs; Effects of Glycosylation on Activity and Blood-Brain Barrier Penetration
2014
doctoral
- Oxytocin Analgesics Without Side Effects for Opioid Use Disorder
Principal Investigator (PI)
2022
$100.0KActive - Development of a Selective Mu-Delta Opioid Receptor Heterodimer Antagonist for Enhancing Opioid Analgesia while Reducing Side Effects
Co-Investigator (COI)
2021
$499.4KActive - IND Enabling Studies for a Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Alzheimer's Disease Related Dementia
Co-Investigator (COI)
2020
$8.0MActive - IND Enabling Studies for a Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Alzheimer's Disease Related Dementia
Co-Investigator (COI)
2020
$128.2KActive - Glycosylated Endomorphin Analogs for Treatment of Opioid Use Disorder (OUD)
Principal Investigator (PI)
2021
$46.0K - MOR/DOR Heterodimer Antagonists: A Novel Treatment for Opioid Dependence
Co-Investigator (COI)
2019
$1.2M - PACAP/VIP Glycopeptide Agonists as Neuroprotective Therapies for Parkinson's Disease
Principal Investigator (PI)
2015
$2.0M - PACAP Antagonists as Novel Migraine Therapies
Principal Investigator (PI)
2014
$25.0K - NSMDS: Molecular Design, Synthesis and Characterization of Green Glycolipid Surfactants
Co-Investigator (COI)
2013
$4.5M - Opioid glycopeptides for the treatment of levodopa-induced dyskinesia
Co-Investigator (COI)
2012
$75.0K
- Following nature's rules, researchers develop new methods for treating degenerative neurological disease
2022
- UA Startup Advances New Therapies for Vascular Dementia
2017
- UA Research goes from Idea to Patent to Market
2015
- Catapulting UA Discoveries to the World
2014
- UA Pain Research Team Awarded $2.5M to Tackle Chronic Pain
2013
- UA Student Earns Howard Hughes Award
2009
- Interdisciplinary UA, NAU Team Receives $3.3 million to Study Biosurfactants
2007
- Valley Fever Drug Phase 1 and 2 Clinical Trial Funded
2007
- UArizona reports record number of inventions
- Design and Synthesis of Novel Brain Penetrant Glycopeptide Analogues of PACAP with Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism.
2022
- Spray-Dried Inhalable Powder Formulations of Therapeutic Proteins and Peptides.
2021
- Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin 1-7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers.
2021
- Lessons in Stereochemistry: Resolution, Synthesis, and Characterization of Chiral Compounds
2020
- The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia
2020
- Glycopeptide drugs: A pharmacological dimension between Small Molecules and Biologics
2020
- Characterization of Delta Opioid Receptor Activity of MMP2200, a Mixed Efficacy Mu and Delta Opioid Receptor Agonist
2020
- Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin for Respiratory Delivery: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies.
2020
- Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers.
2020
- In silico Docking Studies of Fingolimod and S1P1 Agonists.
2020
- Biodegradability and toxicity of cellobiosides and melibiosides
2020
- Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration
2020
- Highly-selective µ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model.
2020
- Biodegradability and toxicity of monorhamnolipid biosurfactant diastereomers
2019
- The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced L-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia
2018
- An update on sphingosine-1-phosphate receptor 1 modulators.
2018
- The opioid glycopeptide MMP-2200: Analysis in preclinical models of L-DOPA-induced dyskinesia
2017
- Synthesis and Characterization of Four Diastereomers of Monorhamnolipids
2017
- Alkyl-melibioside and Alkyl-cellobioside Solution Phase Properties: Effect of Sugar Headgrouand Alkyl Chain Length on Surfactant Performance
2016
- Preparation of S-Glycoside Surfactants and Cysteine Thioglycosides
2016
- The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence
2015
- CNS active O-linked glycopeptides.
2015
- Glycolipids and glycopeptides: Minimally competent Lewis acid catalysis produces surfactants for use ex vivo and in vivo
2015
- Structural Requirements for CNS Active Opioid Glycopeptides
2015
- Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?
2014
- A PM-IRRAS Investigation of Monorhamnolipid Orientation at the Air-Water Interface
2013
- CNS penetration of the opioid glycopeptide MMP-2200: a microdialysis study.
2012
- Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins
2012
- Minimally Competent Lewis Acid Catalysts: Indium(III) and Bismuth(III) Salts Produce Rhamnosides 6‐Deoxymannosides) in High Yield and Purity
2012
- Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids
2012
- Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease
2011
- Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments
2011
- (S)Methyl 2-S)2-bis(4-methoxyphenyl)methylideneamino]3- hydroxypropanamido}3-methylbutanoate
2011
- In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice
2011
- (S)Methyl 2-S)2-bis-4-meth-oxy-phen-yl)methyl-idene-amino]3-hy-droxy-propanamido}3-methyl-butano-ate.
2010
- Serine and threonine Schiff base esters react with β-anomeric peracetates in the presence of BF sub 3 sub ·Et sub 2 sub O to produce β-glycosides
2010
- Synthetic Method for the Development of Monorhamnolipids
2010
- Glycosyl-enkephalins: synthesis and binding at the mu, delta kappa opioid receptors. Antinociception in mice
2009
- Assessment of the efficacy and side effect profile of morphine and MMP2200, a mixed delta/mu agonist
2009
- Structural studies on the neutral glycosphingolipids of Manduca sexta.
2008
- Endoglycosidases: Biochemistry, Biotechnology, Application Edited by Masahiko Endo Hirosaki University, Aomori, Japan) Sumihiro Hase Osaka University, Osaka, Japan) Kenji Yamamoto Kyoto University, Kyoto, Japan) and Keiichi Takagaki Hirosaki University School of Medicine, Aomori, Japan) Kodansha Ltd: Tokyo and Springer: Berlin, Heidelberg, New York. 2006. xvi 255 pp. 169.00. ISBN 4-06-212192-2 Kodansha) and 3-540-34494-2 Springer)
2008
- Behavioral pharmacology of the μ/δ opioid glycopeptide MMP2200 in rhesus monkeys
2008
- Glycosylation improves the central effects of DAMGO
2007
- Sugar synthesis from a gas-phase formose reaction
2007
- Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability
2006
- Glycosylated neuropeptides: A new vista for neuropsychopharmacology?
2005
- N-DIPHENYLMETHYLENE-PROTECTED GLYCOSYL ACCEPTORS SELECTIVE BETA-O-GLYCOSYLATION TO FORM LACTOSYL-THREO-CERAMIDES
2005
- Improved bioavailability to the brain of glycosylated Met-enkephalin analogs
2005
- Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers
2005
- Biousian glycopeptides penetrate the blood-brain barrier
2005
- INVESTIGATING THE INTERSTELLAR CHEMISTRY LEADING TO SIMPLE SUGARS
2005
- New prospects for glycopeptide based analgesia: Glycoside-induced penetration of the Blood-Brain Barrier
2005
- New PDMP analogues inhibit process outgrowth in an insect cell line
2004
- Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta
2004
- Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.
2004
- BETA-AMINO ALCOHOLS FROM AMINO-ACIDS CHELATION CONTROL VIA SCHIFF-BASES
2004
- Optically active 4- and 5-coordinate transition metal complexes of bifurcated dipeptide Schiff bases
2003
- Glycopeptide-membrane interactions: Glycosyl enkephalin analogues adopt turn conformations by NMR and CD in amphipathic media
2003
- GLYCOPEPTIDE ENKEPHALIN ANALOGS PRODUCE ANALGESIA IN MICE EVIDENCE FOR PENETRATION OF THE BLOOD-BRAIN-BARRIER
2003
- Deprotonation of Chelating Enamines. Direct Formation of β‐Lithio Enamines.
2002
- Glycopeptide analgesics
2001
- Lipo α-amino-β-hydroxy acids and O-linked glycosides: Building blocks for ceramyl and glycosphingoyl peptides
2001
- Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin.
2001
- O-linked glycopeptides retain helicity in water
2001
- Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.
2000
- AN ENANTIOSELECTIVE SYNTHESIS OF N-METHYLFUCOSAMINE VIA TANDEM C-C C-O BOND FORMATION
2000
- Lipid Synthesis and Manufacture Edited by Frank D. Gunstone Professor Emeritus, University of St. Andrews, Dundee, Scotland) CRC Press: Boca Raton. 1999. xv 472 pp. 135.00. ISBN 0-8493-9737-5.
2000
- Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides
2000
- Enkephalin-based drug design: conformational analysis of O-linked glycopeptides by NMR and molecular modeling
2000
- Asymmetric syntheses of 8-epi-swainsonine triacetate and 1,2-di-epi-swainsonine. Carbonyl addition thwarted by an unprecedented aza-pinacol rearrangement
2000
- ALKYLATION OF IMIDAZOLIDINONE DIPEPTIDE DERIVATIVES PREPARATION OF ENANTIOMERICALLY PURE DIPEPTIDES AND TRIPEPTIDES BY CHIRALITY TRANSFER VIA A PIVALALDEHYDE N,N-ACETAL CENTER
2000
- Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.
2000
- Glycosidase inhibitors: Synthesis of enantiomerically pure aza-sugars from Schiff base amino esters via tandem reduction-alkenylation and osmylation
1999
- Syntheses of iminolyxitols via tandem reduction-alkenylation of O'Donnell's Schiff bases
1998
- Glycosyltransferase inhibitors: Synthesis of D-threo-PDMP, L-threo- PDMP, and other brain glucosylceramide synthase inhibitors from D- or L- serine
1998
- SYNTHESES OF IMINOLYXITOLS VIA TANDEM REDUCTION-ALKENYLATION OF O DONNELL S SCHIFF BASES
1998
- STEREOSELECTIVE SYNTHESIS OF O-SERINYL/THREONINYL-2-ACETAMIDO-2-DEOXY-ALPHA-GLYCOSIDES OR O-SERINYL/THREONINYL-2-ACETAMIDO-2-DEOXY-BETA-GLYCOSIDES
1997
- General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases
1997
- Amino acid-derived ligands for transition metals: Catalysis via a minimalist interpretation of a metalloprotein
1997
- New chemical method for synthesis of O-linked glycopeptides
1996
- DESIGN AND SYNTHESIS OF PEPTIDE LIGANDS WITH UNIQUE BIOCHEMICAL AND BIOLOGICAL PROFILES AT OPIOID RECEPTORS THAT CROSS THE BLOOD BRAIN BARRIER
1995
- Stereoselective synthesis of O-serinyl/threoninyl-2-acetamido-2-deoxy-α- or β-glycosides
1995
- Piperidine Triols via Enantioselective Alkylation and Osmylation of Alanine Schiff Base Esters
1995
- Preparation of monosilyl acetals from esters via iBu sub 2 sub AlH reduction and trapping with N-trimethylsilyl)imidazole. Addition of allyltrimethylsilane to yield homoallylic alcohols or ethers
1995
- An enantioselective synthesis of N-methylfucosamine via tandem C-C/C-O bond formation
1994
- New opioid compounds in analgesia
1994
- ASSESSMENT OF AN IN-VITRO BLOOD-BRAIN-BARRIER MODEL USING SEVERAL MET5]ENKEPHALIN OPIOID ANALOGS
1994
- A systematic study of glycolaldehyde in sagittarius B2(N) at 2 and 3 mm: Criteria for detecting large interstellar molecules
1994
- Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
1994
- Stereoselective synthesis of β-D-glycopyranosyl-L-serinate or threoninate derivatives with an unusual migration
1994
- N-diphenylmethylene-protected glycosyl acceptors. Selective β-O-glycosylation to form lactosyl-threo-ceramides
1993
- Determination and metabolism of dithiol chelating agents. XV. The meso- 2,3-dimercaptosuccinic acid-cysteine 1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat
1993
- GENERAL-METHODS FOR ALPHA-O-SER/THR OR BETA-O-SER/THR GLYCOSIDES AND GLYCOPEPTIDES SOLID-PHASE SYNTHESIS OF O-GLYCOSYL CYCLIC ENKEPHALIN ANALOGS
1993
- O-GLYCOPEPTIDES A SIMPLE BETA-STEREOSELECTIVE GLYCOSIDATION OF SERINE AND THREONINE VIA A FAVORABLE HYDROGEN-BONDING PATTERN
1993
- Assessment of an in vitro blood-brain barrier model using several Met5]enkephalin opioid analogs.
1993
- β-Alkoxy Schiff base–oxazolidine tautomerism: solid-state structure of N-diphenylmethylene-l-threonine methyl ester
1993
- Catalysis by amino acid-derived tetracoordinate complexes: Enantioselective addition of dialkylzincs to aliphatic and aromatic aldehydes
1992
- A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.
1992
- General Methods for α- or β-O-Ser/Thr Glycosides and Glycopeptides. Solid-Phase Synthesis of O-Glycosyl Cyclic Enkephalin Analogues
1992
- Aluminoxy acetals from α-amino esters: Chirality transfer via sequential addition of hydride and C-nucleophiles. 2-Amino alcohols and sphingosines
1992
- E-1-lithio-1-alkenes in hydrocarbon solvent
1992
- Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation
1991
- Erythrose sesqui-acetals as electrophiles. 2-Deoxy-C-nucleosides from D-glucose.
1991
- O-glycopeptides: a simple β-stereoselective glycosidation of serine and threonine via a favorable hydrogen bonding pattern.
1991
- β-Amino alcohols from amino acids: Chelation control via schiff bases.
1990
- Stereoselective alkylation of glycine units in dipeptide derivatives: Chirality transfer via a pivalaldehyde N,N-acetal center
1989
- Acidities of glycine Schiff bases and alkylation of their conjugate bases
1988
- Theoretical studies of the lithiation of enamines
1988
- STEREOSELECTIVE ALKYLATION OF GLYCINE UNITS IN DIPEPTIDE DERIVATIVES CHIRALITY TRANSFER VIA A PIVALALDEHYDE N,N-ACETAL CENTER
1987
- Alkylation of Imidazolidinone Dipeptide Derivatives: Preparation of Enantiomerically Pure Di‐ and Tripeptides by ‘Chirality Transfer’ via a Pivalaldehyde N,N‐Acetal Center. Preliminary Communication
1987
- Deprotonation of chelating enamines. Direct formation of β-lithio enamines
1986
- Preparation of an Electrophilic Glycine Cation Equivalent and Its Reaction with Heteroatom Nucleophiles. The Synthesis of Amino Acids by Reaction of an Electrophilic Glycine Cation Equivalent with Carbon Nucleophiles.
1985
- Preparation of an electrophilic glycine cation equivalent and its reaction with heteroatom nucleophiles
1985
- X-ray crystal structure of N-2-lithiocyclohexenyl)N,N′,N′-trimethyl-1,3-propanediamine: A pentavalent lithium?
1984
- A mild and efficient route to Schiff base derivatives of amino acids
1982