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Michael Marty, Ph.D., is an Assistant Professor of Chemistry & Biochemistry at The University of Arizona. Dr. Marty earned his B.A. in chemistry and mathematics at St. Olaf College in 2010, graduating summa cum laude and Phi Beta Kappa. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois Urbana-Champaign in 2013 followed by postdoctoral research at the University of Oxford until joining the faculty in 2016. He has been awarded the ASMS Research Award, the Bisgrove Scholar Award, and the NIH MIRA award. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins, antimicrobial peptides, and their interactions with lipid bilayers.
Courses
  • MS
    Mass Spectrometry

  • AC
    Analytical Chemistry

Student Thesis/Dissertation
  • Interfacing Nanodiscs with Native Mass Spectrometry to Study Membrane Protein-Lipid Interactions

    2022

    doctoral
  • Analysis of Mixed Lipid Nanodiscs and Viral Capsids with Native Mass Spectrometry and Charge Detection-Mass Spectrometry

    2022

    doctoral
  • Investigating Peptide-Lipid Interactions in Nanodiscs Using Native Mass Spectrometry and Fast Photochemical Oxidation of Peptides

    2022

    doctoral
  • INTERPRETING COMPLEX MASS SPECTRA THROUGH DOUBLE DECONVOLUTION ANALYSIS

    2022

    bachelors
  • Structural and Mechanistic Insights into the Yeast TORC1-Body

    2021

    doctoral
  • Using Top-Down Mass Spectrometry to Identify and Characterize Endogenous Membrane Protein Complexes

    2019

    masters
Grants
  • Funding agency logo
    Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry

    Principal Investigator (PI)

    2023

    $407.0K
    Active
  • Funding agency logo
    Impacts of Host Lipid Composition on Antimicrobial Susceptibilities of Staphylococcus Aureus.

    Principal Investigator (PI)

    2022

    $50.6K
    Active
  • Funding agency logo
    MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research

    Co-Investigator (COI)

    2020

    $342.9K
    Active
  • Funding agency logo
    CAREER: Enabling Nanodisc Native Mass Spectrometry to Study Membrane Active Compounds

    Principal Investigator (PI)

    2019

    $750.0K
    Active
  • Funding agency logo
    Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry

    Principal Investigator (PI)

    2018

    $1.9M
    Active
  • Funding agency logo
    Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry

    Principal Investigator (PI)

    2018

    $43.4K
    Active
  • Funding agency logo
    Unraveling the Paradox of Nanodisc Supercharging

    Principal Investigator (PI)

    2018

    $35.0K
  • Funding agency logo
    Hybrid Structural Mass Spectrometry for Rapid Site-Specific Glycan Structural Elucidation

    Principal Investigator (PI)

    2018

    $6.4K
  • Funding agency logo
    UofA 2017 Bisgrove Scholar Program - Dr. Michael Marty

    Co-Investigator (COI)

    2017

    $200.0K
Technologies / Patents
      News
      • Chemist Creates Program to Support Vets in STEM

        2019

      • UA Researchers Win Four of Five State Bisgrove Scholar Awards

        2017

      • Colin Kaltenbach Honored

        2005

      Publications (82)
      Recent
      • Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

        2023

      • Characterizing Adeno-Associated Virus Capsids with both Denaturing and Intact Analysis Methods

        2023

      • UniDec Processing Pipeline for Rapid Analysis of Biotherapeutic Mass Spectrometry Data

        2023

      • Do Nanodisc Assembly Conditions Affect Natural Lipid Uptake?

        2023

      • Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs

        2023

      • Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding

        2023

      • Identifying Membrane Protein-Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry

        2023

      • What’s the defect? Using mass defects to study oligomerization of membrane proteins and peptides in nanodiscs with native mass spectrometry

        2023

      • Online Buffer Exchange Enables Automated Membrane Protein Analysis by Native Mass Spectrometry

        2023

      • Investigating Antimicrobial Peptide-Membrane Interactions Using Fast Photochemical Oxidation of Peptides in Nanodiscs

        2022

      • Lipid tails modulate antimicrobial peptide membrane incorporation and activity

        2022

      • Structural and mechanistic insights into amyloid-β and α-synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers

        2022

      • A unique class of Zn2+binding PBPs underlies cephalosporin resistance and sporogenesis of Clostridioides difficile

        2022

      • Guest Editorial: Bias in Mass Spectrometry Technical Support

        2022

      • Fourier-Transform Approach for Reconstructing Macromolecular Mass Defect Profiles

        2022

      • Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry

        2022

      • Correction to Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization

        2022

      • Fundamentals: How Do We Calculate Mass, Error, and Uncertainty in Native Mass Spectrometry?

        2022

      • Lipids and Small Molecules Affect α-synuclein Association and Disruption of Nanodiscs

        2022

      • Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors

        2021

      • Investigating the Lipid Selectivity of Membrane Proteins in Heterogeneous Nanodiscs

        2021

      • Native mass spectrometry reveals the simultaneous binding of lipids and zinc to rhodopsin

        2021

      • Protein Modification via Mild Photochemical Isomerization of Triazenes to Release Aryl Diazonium Ions

        2021

      • Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity

        2021

      • Structural basis of omega-3 fatty acid transport across the blood-brain barrier

        2021

      • Direct-MS analysis of antibody-antigen complexes

        2021

      • Influenza AM2 Channel Oligomerization Is Sensitive to Its Chemical Environment

        2021

      • Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry

        2021

      • Illuminating Individual Membrane Protein Complexes with Mass Photometry

        2021

      • UniDecCD: Deconvolution of Charge Detection-Mass Spectrometry Data

        2021

      • GNPS Dashboard: collaborative exploration of mass spectrometry data in the web browser

        2021

      • Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

        2021

      • Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization

        2021

      • Native mass spectrometry for structural biology: A perspective

        2021

      • Native Mass Spectrometry of Membrane Proteins

        2021

      • Albumin Conjugates of Thiosemicarbazone and Imidazole-2-thione Prochelators: Iron Coordination and Antiproliferative Activity

        2021

      • Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions

        2021

      • Investigating the Influences of Lipid Binding on Rhodopsin Activation using Native Mass Spectrometry

        2020

      • Scratching the surface: native mass spectrometry of peripheral membrane protein complexes

        2020

      • Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry

        2020

      • Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.

        2020

      • Measuring Membrane Protein-Lipid Interactions in Nanodiscs with Native Mass Spectrometry

        2020

      • Deconvolving Native and Intact Protein Mass Spectra with UniDec

        2020

      • Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L

        2020

      • Nanodiscs and Mass Spectrometry: Making Membranes Fly.

        2020

      • Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.

        2020

      • Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry

        2020

      • Modeling Natural Bilayers with Mixed Lipid Nanodiscs for Native MS

        2020

      • Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry

        2020

      • Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors

        2020

      • MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra.

        2019

      • Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes

        2019

      • Measuring the Stoichiometry of Antimicrobial Peptides in Nanodiscs with Native Mass Spectrometry

        2019

      • Eliminating Artifacts in Electrospray Deconvolution with a SoftMax Function

        2019

      • Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry

        2019

      • Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly

        2019

      • Validating Enterovirus D68-2A as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2A Inhibitor

        2019

      • A Universal Score for Deconvolution of Intact Protein and Native Electrospray Mass Spectra

        2019

      • Characterizing the Lipid Annulus Surrounding Membrane Proteins with Native Mass Spectrometry of Nanodiscs

        2018

      • MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra

        2018

      • Investigation of Photoinduced Oligomerization of Rhodopsin by Native Mass Spectrometry

        2018

      • Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs

        2018

      • Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins

        2018

      • Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions

        2018

      • Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry

        2017

      • Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors

        2017

      • Unraveling the Composition and Behavior of Heterogeneous Lipid Nanodiscs by Mass Spectrometry

        2016

      • Probing the Lipid Annular Belt by Gas-Phase Dissociation of Membrane Proteins in Nanodiscs

        2016

      • Interfacing Membrane Mimetics with Mass Spectrometry

        2016

      • High-resolution mass spectrometry of small molecules bound to membrane proteins

        2016

      • A sliding selectivity scale for lipid binding to membrane proteins

        2016

      • Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins

        2015

      • The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry

        2015

      • Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers

        2015

      • Bayesian deconvolution of mass and ion mobility spectra: From binary interactions to polydisperse ensembles

        2015

      • Interpretation and deconvolution of nanodisc native mass spectra

        2014

      • Nanodisc-solubilized membrane protein library reflects the membrane proteome

        2013

      • Simulating a time-of-flight mass spectrometer: A labview exercise

        2013

      • Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening

        2013

      • Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs

        2012

      • Native mass spectrometry characterization of intact nanodisc lipoprotein complexes

        2012

      • Nonlinear analyte concentration gradients for one-stekinetic analysis employing optical microring resonators

        2012

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