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Michael Marty

Assistant Professor, BIO5 Institute,
Associate Professor, Chemistry and Biochemistry-Sci,
Assistant Professor, Chemistry and Biochemistry - Med,
Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
mtmarty@arizona.edu
520/621-1501
UAVitae logogoogle scholar logoOrcid logo
Grant: $3.3M
Michael Marty, Ph.D., is an Assistant Professor of Chemistry & Biochemistry at The University of Arizona. Dr. Marty earned his B.A. in chemistry and mathematics at St. Olaf College in 2010, graduating summa cum laude and Phi Beta Kappa. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois Urbana-Champaign in 2013 followed by postdoctoral research at the University of Oxford until joining the faculty in 2016. He has been awarded the ASMS Research Award, the Bisgrove Scholar Award, and the NIH MIRA award. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins, antimicrobial peptides, and their interactions with lipid bilayers.
Michael Marty experts in mass spectrometry, proteomics, biochemistry, structural biology, biomaterials, biophysics, molecular biology, drug delivery, metabolomics, bioinformatics, machine learning, analytical chemistry, computer vision, deep learning, virology, tissue engineering, biomedical optics, biophotonics, bioengineering, organic chemistry, nanomedicine, bayesian statistics, biostatistics, membrane proteins, lipids, neuroscience, pain, regenerative medicine, cryo-em, pharmacology, enzymology, organometallic chemistry, fluorescence microscopy, medicinal chemistry, photochemistry, bioinorganic chemistry, microbiology, antimicrobial peptides, microfluidics, biomems, computational biology, cell biology
Courses
Analytical Chemistry 
Mass Spectrometry 
Recent Grants
Logo of MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research funding agency
2020 $342.9KActive
MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
Logo of CAREER: Enabling Nanodisc Native Mass Spectrometry to Study Membrane Active Compounds funding agency
2019 $750.0KActive
CAREER: Enabling Nanodisc Native Mass Spectrometry to Study Membrane Active Compounds
Logo of Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry funding agency
2018 $1.9MActive
Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
Logo of Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry funding agency
2018 $43.4KActive
Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
Logo of Unraveling the Paradox of Nanodisc Supercharging funding agency
2018 $35.0K
Unraveling the Paradox of Nanodisc Supercharging
Logo of Hybrid Structural Mass Spectrometry for Rapid Site-Specific Glycan Structural Elucidation funding agency
2018 $6.4K
Hybrid Structural Mass Spectrometry for Rapid Site-Specific Glycan Structural Elucidation
Logo of UofA 2017 Bisgrove Scholar Program - Dr. Michael Marty funding agency
2017 $200.0K
UofA 2017 Bisgrove Scholar Program - Dr. Michael Marty
Technologies / Patents
Logo of Automated Lipid Exchange-Mass Spectrometry System
1899Automated Lipid Exchange-Mass Spectrometry System 
News
2019Chemist Creates Program to Support Vets in STEM 
2017UA Researchers Win Four of Five State Bisgrove Scholar Awards 
2005Colin Kaltenbach Honored  
Publications (82)
Recent
2023Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs 
2023Interspecies Variation Affects IAPP Membrane Binding 
2022Fourier-Transform Approach for Reconstructing Macromolecular Mass Defect Profiles 
2022A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis of Clostridioides difficile 
2022Correction to Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization 
2022Guest Editorial: Bias in Mass Spectrometry Technical Support 
2022Lipids and Small Molecules Affect α-synuclein Association and Disruption of Nanodiscs 
2022Structural and mechanistic insights into amyloid-β and α-synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers 
2022Investigating Daptomycin-Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs 
2022Investigating Antimicrobial Peptide–Membrane Interactions Using Fast Photochemical Oxidation of Peptides in Nanodiscs 
2022Fundamentals: How Do We Calculate Mass, Error, and Uncertainty in Native Mass Spectrometry? 
2022Lipid tails modulate antimicrobial peptide membrane incorporation and activity 
2022Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry 
2022Lipids and EGCG Affect α-Synuclein Association and Disruption of Nanodiscs 
2021Influenza AM2 Channel Oligomerization Is Sensitive to Its Chemical Environment 
2021GNPS Dashboard: collaborative exploration of mass spectrometry data in the web browser 
2021Illuminating Individual Membrane Protein Complexes with Mass Photometry 
2021Structural basis of omega-3 fatty acid transport across the blood-brain barrier 
2021Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay 
2021Native mass spectrometry for structural biology: A perspective 
2021Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay 
2021Protein Modification via Mild Photochemical Isomerization of Triazenes to Release Aryl Diazonium Ions 
2021Native Mass Spectrometry of Membrane Proteins 
2021Albumin Conjugates of Thiosemicarbazone and Imidazole-2-thione Prochelators: Iron Coordination and Antiproliferative Activity 
2021Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. 
2021Native Mass Spectrometry Reveals the Simultaneous Binding of Lipids and Zinc to Rhodopsin 
2021Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization 
2021Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021) 
2021Investigating the Lipid Selectivity of Membrane Proteins in Heterogeneous Nanodiscs 
2021Direct-MS analysis of antibody-antigen complexes 
2021UniDecCD: Deconvolution of Charge Detection-Mass Spectrometry Data 
2021Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity 
2021Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions 
2021Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry 
2020Scratching the surface: native mass spectrometry of peripheral membrane protein complexes 
2020Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry 
2020Investigating the Influences of Lipid Binding on Rhodopsin Activation using Native Mass Spectrometry 
2020Measuring Membrane Protein-Lipid Interactions in Nanodiscs with Native Mass Spectrometry 
2020Deconvolving Native and Intact Protein Mass Spectra with UniDec 
2020Nanodiscs and Mass Spectrometry: Making Membranes Fly. 
2020Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M<sup>pro</sup> and cathepsin L 
2020Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. 
2020Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors 
2020Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors 
2020Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M and cathepsin L 
2020Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry 
2020Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis. 
2020Modeling Natural Bilayers with Mixed Lipid Nanodiscs for Native MS 
2020Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry 
2019MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra. 
2019Validating enterovirus D68-2A<sup>pro</sup> as an antiviral drug target and the discovery of telaprevir as a potent D68-2APro inhibitor 
2019Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry 
2019Measuring the Stoichiometry of Antimicrobial Peptides in Nanodiscs with Native Mass Spectrometry 
2019Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes 
2019Eliminating Artifacts in Electrospray Deconvolution with a SoftMax Function 
2019A Universal Score for Deconvolution of Intact Protein and Native Electrospray Mass Spectra 
2019Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly 
2019Validating Enterovirus D68-2A as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2A Inhibitor 
2018Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs 
2018MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra 
2018Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions 
2018Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins 
2018Investigation of Photoinduced Oligomerization of Rhodopsin by Native Mass Spectrometry 
2018Characterizing the Lipid Annulus Surrounding Membrane Proteins with Native Mass Spectrometry of Nanodiscs 
2017Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry 
2017Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors 
2016High-resolution mass spectrometry of small molecules bound to membrane proteins 
2016A sliding selectivity scale for lipid binding to membrane proteins 
2016Probing the Lipid Annular Belt by Gas-Phase Dissociation of Membrane Proteins in Nanodiscs 
2016Interfacing Membrane Mimetics with Mass Spectrometry 
2016Unraveling the Composition and Behavior of Heterogeneous Lipid Nanodiscs by Mass Spectrometry 
2015Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles 
2015The effect of detergent, temperature, and lipid on the oligomeric state of MscL constructs: Insights from mass spectrometry 
2015Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers 
2015Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins 
2014Interpretation and deconvolution of nanodisc native mass spectra 
2013Simulating a Time-of-Flight Mass Spectrometer: A LabView Exercise 
2013Nanodisc-solubilized membrane protein library reflects the membrane proteome 
2013Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening 
2012Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs 
2012Nonlinear Analyte Concentration Gradients for One-Step Kinetic Analysis Employing Optical Microring Resonators 
2012Native mass spectrometry characterization of intact nanodisc lipoprotein complexes 
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