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Michael Marty

Assistant Professor, BIO5 Institute,

Associate Professor, Chemistry and Biochemistry-Sci,

Assistant Professor, Chemistry and Biochemistry - Med,

Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
mtmarty@arizona.edu

520/621-1501

Grant: $3.3M

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Michael Marty, Ph.D., is an Assistant Professor of Chemistry & Biochemistry at The University of Arizona. Dr. Marty earned his B.A. in chemistry and mathematics at St. Olaf College in 2010, graduating summa cum laude and Phi Beta Kappa. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois Urbana-Champaign in 2013 followed by postdoctoral research at the University of Oxford until joining the faculty in 2016. He has been awarded the ASMS Research Award, the Bisgrove Scholar Award, and the NIH MIRA award. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins, antimicrobial peptides, and their interactions with lipid bilayers.

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Michael Marty experts in mass spectrometry, proteomics, biochemistry, structural biology, biomaterials, biophysics, molecular biology, drug delivery, metabolomics, bioinformatics, machine learning, analytical chemistry, computer vision, deep learning, virology, tissue engineering, biomedical optics, biophotonics, bioengineering, organic chemistry, nanomedicine, bayesian statistics, biostatistics, membrane proteins, lipids, neuroscience, pain, regenerative medicine, cryo-em, pharmacology, enzymology, organometallic chemistry, fluorescence microscopy, medicinal chemistry, photochemistry, bioinorganic chemistry, microbiology, antimicrobial peptides, microfluidics, biomems, computational biology, cell biology

Courses

Analytical Chemistry

Mass Spectrometry

Recent Grants

	2020	$342.9K	Active
MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
	2019	$750.0K	Active
CAREER: Enabling Nanodisc Native Mass Spectrometry to Study Membrane Active Compounds
	2018	$1.9M	Active
Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
	2018	$43.4K	Active
Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
	2018	$35.0K
Unraveling the Paradox of Nanodisc Supercharging
	2018	$6.4K
Hybrid Structural Mass Spectrometry for Rapid Site-Specific Glycan Structural Elucidation
	2017	$200.0K
UofA 2017 Bisgrove Scholar Program - Dr. Michael Marty

Technologies / Patents

1899

Automated Lipid Exchange-Mass Spectrometry System

News

2019	Chemist Creates Program to Support Vets in STEM
2017	UA Researchers Win Four of Five State Bisgrove Scholar Awards
2005	Colin Kaltenbach Honored

Publications (82)

Recent

2023	Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs
2023	Interspecies Variation Affects IAPP Membrane Binding
2022	Fourier-Transform Approach for Reconstructing Macromolecular Mass Defect Profiles
2022	A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis of Clostridioides difficile
2022	Correction to Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization
2022	Guest Editorial: Bias in Mass Spectrometry Technical Support
2022	Lipids and Small Molecules Affect α-synuclein Association and Disruption of Nanodiscs
2022	Structural and mechanistic insights into amyloid-β and α-synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers
2022	Investigating Daptomycin-Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs
2022	Investigating Antimicrobial Peptide–Membrane Interactions Using Fast Photochemical Oxidation of Peptides in Nanodiscs
2022	Fundamentals: How Do We Calculate Mass, Error, and Uncertainty in Native Mass Spectrometry?
2022	Lipid tails modulate antimicrobial peptide membrane incorporation and activity
2022	Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry
2022	Lipids and EGCG Affect α-Synuclein Association and Disruption of Nanodiscs
2021	Influenza AM2 Channel Oligomerization Is Sensitive to Its Chemical Environment
2021	GNPS Dashboard: collaborative exploration of mass spectrometry data in the web browser
2021	Illuminating Individual Membrane Protein Complexes with Mass Photometry
2021	Structural basis of omega-3 fatty acid transport across the blood-brain barrier
2021	Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay
2021	Native mass spectrometry for structural biology: A perspective
2021	Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay
2021	Protein Modification via Mild Photochemical Isomerization of Triazenes to Release Aryl Diazonium Ions
2021	Native Mass Spectrometry of Membrane Proteins
2021	Albumin Conjugates of Thiosemicarbazone and Imidazole-2-thione Prochelators: Iron Coordination and Antiproliferative Activity
2021	Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
2021	Native Mass Spectrometry Reveals the Simultaneous Binding of Lipids and Zinc to Rhodopsin
2021	Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization
2021	Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021)
2021	Investigating the Lipid Selectivity of Membrane Proteins in Heterogeneous Nanodiscs
2021	Direct-MS analysis of antibody-antigen complexes
2021	UniDecCD: Deconvolution of Charge Detection-Mass Spectrometry Data
2021	Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity
2021	Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions
2021	Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry
2020	Scratching the surface: native mass spectrometry of peripheral membrane protein complexes
2020	Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry
2020	Investigating the Influences of Lipid Binding on Rhodopsin Activation using Native Mass Spectrometry
2020	Measuring Membrane Protein-Lipid Interactions in Nanodiscs with Native Mass Spectrometry
2020	Deconvolving Native and Intact Protein Mass Spectra with UniDec
2020	Nanodiscs and Mass Spectrometry: Making Membranes Fly.
2020	Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M<sup>pro</sup> and cathepsin L
2020	Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.
2020	Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors
2020	Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors
2020	Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M and cathepsin L
2020	Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry
2020	Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.
2020	Modeling Natural Bilayers with Mixed Lipid Nanodiscs for Native MS
2020	Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry
2019	MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra.
2019	Validating enterovirus D68-2A<sup>pro</sup> as an antiviral drug target and the discovery of telaprevir as a potent D68-2APro inhibitor
2019	Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry
2019	Measuring the Stoichiometry of Antimicrobial Peptides in Nanodiscs with Native Mass Spectrometry
2019	Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes
2019	Eliminating Artifacts in Electrospray Deconvolution with a SoftMax Function
2019	A Universal Score for Deconvolution of Intact Protein and Native Electrospray Mass Spectra
2019	Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly
2019	Validating Enterovirus D68-2A as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2A Inhibitor
2018	Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs
2018	MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra
2018	Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions
2018	Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins
2018	Investigation of Photoinduced Oligomerization of Rhodopsin by Native Mass Spectrometry
2018	Characterizing the Lipid Annulus Surrounding Membrane Proteins with Native Mass Spectrometry of Nanodiscs
2017	Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry
2017	Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors
2016	High-resolution mass spectrometry of small molecules bound to membrane proteins
2016	A sliding selectivity scale for lipid binding to membrane proteins
2016	Probing the Lipid Annular Belt by Gas-Phase Dissociation of Membrane Proteins in Nanodiscs
2016	Interfacing Membrane Mimetics with Mass Spectrometry
2016	Unraveling the Composition and Behavior of Heterogeneous Lipid Nanodiscs by Mass Spectrometry
2015	Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles
2015	The effect of detergent, temperature, and lipid on the oligomeric state of MscL constructs: Insights from mass spectrometry
2015	Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers
2015	Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins
2014	Interpretation and deconvolution of nanodisc native mass spectra
2013	Simulating a Time-of-Flight Mass Spectrometer: A LabView Exercise
2013	Nanodisc-solubilized membrane protein library reflects the membrane proteome
2013	Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening
2012	Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs
2012	Nonlinear Analyte Concentration Gradients for One-Step Kinetic Analysis Employing Optical Microring Resonators
2012	Native mass spectrometry characterization of intact nanodisc lipoprotein complexes

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