❝
Michael Marty, Ph.D., is an Assistant Professor of Chemistry & Biochemistry at The University of Arizona. Dr. Marty earned his B.A. in chemistry and mathematics at St. Olaf College in 2010, graduating summa cum laude and Phi Beta Kappa. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois Urbana-Champaign in 2013 followed by postdoctoral research at the University of Oxford until joining the faculty in 2016. He has been awarded the ASMS Research Award, the Bisgrove Scholar Award, and the NIH MIRA award. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins, antimicrobial peptides, and their interactions with lipid bilayers.Show Less
Courses
- MSMass Spectrometry
- ACAnalytical Chemistry
Student Thesis/Dissertation
- Interfacing Nanodiscs with Native Mass Spectrometry to Study Membrane Protein-Lipid Interactions
2022
doctoral - Analysis of Mixed Lipid Nanodiscs and Viral Capsids with Native Mass Spectrometry and Charge Detection-Mass Spectrometry
2022
doctoral - Investigating Peptide-Lipid Interactions in Nanodiscs Using Native Mass Spectrometry and Fast Photochemical Oxidation of Peptides
2022
doctoral - INTERPRETING COMPLEX MASS SPECTRA THROUGH DOUBLE DECONVOLUTION ANALYSIS
2022
bachelors - Elucidating the Mechanism Behind Altered Retinal Dynamics in Age-Related Macular Degeneration
2021
masters - Structural and Mechanistic Insights into the Yeast TORC1-Body
2021
doctoral - Using Top-Down Mass Spectrometry to Identify and Characterize Endogenous Membrane Protein Complexes
2019
masters
Grants
- Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
Principal Investigator (PI)
2023
$407.0KActive - Impacts of Host Lipid Composition on Antimicrobial Susceptibilities of Staphylococcus Aureus.
Principal Investigator (PI)
2022
$50.6KActive - MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
Co-Investigator (COI)
2020
$342.9KActive - CAREER: Enabling Nanodisc Native Mass Spectrometry to Study Membrane Active Compounds
Principal Investigator (PI)
2019
$750.0KActive - Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
Principal Investigator (PI)
2018
$1.9MActive - Unravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass Spectrometry
Principal Investigator (PI)
2018
$43.4KActive - Unraveling the Paradox of Nanodisc Supercharging
Principal Investigator (PI)
2018
$35.0K - Hybrid Structural Mass Spectrometry for Rapid Site-Specific Glycan Structural Elucidation
Principal Investigator (PI)
2018
$6.4K - UofA 2017 Bisgrove Scholar Program - Dr. Michael Marty
Co-Investigator (COI)
2017
$200.0K
Technologies / Patents
News
- Chemist Creates Program to Support Vets in STEM
2019
- UA Researchers Win Four of Five State Bisgrove Scholar Awards
2017
- Colin Kaltenbach Honored
2005
Publications (82)
Recent
- Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions
2023
- Characterizing Adeno-Associated Virus Capsids with both Denaturing and Intact Analysis Methods
2023
- UniDec Processing Pipeline for Rapid Analysis of Biotherapeutic Mass Spectrometry Data
2023
- Do Nanodisc Assembly Conditions Affect Natural Lipid Uptake?
2023
- Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs
2023
- Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding
2023
- Identifying Membrane Protein-Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry
2023
- What’s the defect? Using mass defects to study oligomerization of membrane proteins and peptides in nanodiscs with native mass spectrometry
2023
- Online Buffer Exchange Enables Automated Membrane Protein Analysis by Native Mass Spectrometry
2023
- Investigating Antimicrobial Peptide-Membrane Interactions Using Fast Photochemical Oxidation of Peptides in Nanodiscs
2022
- Lipid tails modulate antimicrobial peptide membrane incorporation and activity
2022
- Structural and mechanistic insights into amyloid-β and α-synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers
2022
- A unique class of Zn2+binding PBPs underlies cephalosporin resistance and sporogenesis of Clostridioides difficile
2022
- Guest Editorial: Bias in Mass Spectrometry Technical Support
2022
- Fourier-Transform Approach for Reconstructing Macromolecular Mass Defect Profiles
2022
- Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry
2022
- Correction to Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization
2022
- Fundamentals: How Do We Calculate Mass, Error, and Uncertainty in Native Mass Spectrometry?
2022
- Lipids and Small Molecules Affect α-synuclein Association and Disruption of Nanodiscs
2022
- Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors
2021
- Investigating the Lipid Selectivity of Membrane Proteins in Heterogeneous Nanodiscs
2021
- Native mass spectrometry reveals the simultaneous binding of lipids and zinc to rhodopsin
2021
- Protein Modification via Mild Photochemical Isomerization of Triazenes to Release Aryl Diazonium Ions
2021
- Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity
2021
- Structural basis of omega-3 fatty acid transport across the blood-brain barrier
2021
- Direct-MS analysis of antibody-antigen complexes
2021
- Influenza AM2 Channel Oligomerization Is Sensitive to Its Chemical Environment
2021
- Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry
2021
- Illuminating Individual Membrane Protein Complexes with Mass Photometry
2021
- UniDecCD: Deconvolution of Charge Detection-Mass Spectrometry Data
2021
- GNPS Dashboard: collaborative exploration of mass spectrometry data in the web browser
2021
- Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay
2021
- Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization
2021
- Native mass spectrometry for structural biology: A perspective
2021
- Native Mass Spectrometry of Membrane Proteins
2021
- Albumin Conjugates of Thiosemicarbazone and Imidazole-2-thione Prochelators: Iron Coordination and Antiproliferative Activity
2021
- Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions
2021
- Investigating the Influences of Lipid Binding on Rhodopsin Activation using Native Mass Spectrometry
2020
- Scratching the surface: native mass spectrometry of peripheral membrane protein complexes
2020
- Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry
2020
- Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.
2020
- Measuring Membrane Protein-Lipid Interactions in Nanodiscs with Native Mass Spectrometry
2020
- Deconvolving Native and Intact Protein Mass Spectra with UniDec
2020
- Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L
2020
- Nanodiscs and Mass Spectrometry: Making Membranes Fly.
2020
- Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.
2020
- Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry
2020
- Modeling Natural Bilayers with Mixed Lipid Nanodiscs for Native MS
2020
- Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry
2020
- Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors
2020
- MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra.
2019
- Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes
2019
- Measuring the Stoichiometry of Antimicrobial Peptides in Nanodiscs with Native Mass Spectrometry
2019
- Eliminating Artifacts in Electrospray Deconvolution with a SoftMax Function
2019
- Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry
2019
- Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly
2019
- Validating Enterovirus D68-2A as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2A Inhibitor
2019
- A Universal Score for Deconvolution of Intact Protein and Native Electrospray Mass Spectra
2019
- Characterizing the Lipid Annulus Surrounding Membrane Proteins with Native Mass Spectrometry of Nanodiscs
2018
- MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra
2018
- Investigation of Photoinduced Oligomerization of Rhodopsin by Native Mass Spectrometry
2018
- Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs
2018
- Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins
2018
- Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions
2018
- Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry
2017
- Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors
2017
- Unraveling the Composition and Behavior of Heterogeneous Lipid Nanodiscs by Mass Spectrometry
2016
- Probing the Lipid Annular Belt by Gas-Phase Dissociation of Membrane Proteins in Nanodiscs
2016
- Interfacing Membrane Mimetics with Mass Spectrometry
2016
- High-resolution mass spectrometry of small molecules bound to membrane proteins
2016
- A sliding selectivity scale for lipid binding to membrane proteins
2016
- Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins
2015
- The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry
2015
- Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers
2015
- Bayesian deconvolution of mass and ion mobility spectra: From binary interactions to polydisperse ensembles
2015
- Interpretation and deconvolution of nanodisc native mass spectra
2014
- Nanodisc-solubilized membrane protein library reflects the membrane proteome
2013
- Simulating a time-of-flight mass spectrometer: A labview exercise
2013
- Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening
2013
- Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs
2012
- Native mass spectrometry characterization of intact nanodisc lipoprotein complexes
2012
- Nonlinear analyte concentration gradients for one-stekinetic analysis employing optical microring resonators
2012
Please report any missing, incorrect data issues or provide feedback to help us improve the KMap.