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I am interested in mosquito physiology and the interactions between mosquitoes and human pathogens such as malaria parasites, dengue virus and Zika virus. My lab is currently exploring how various signaling pathways, such as JNK and the insulin/insulin growth factor 1 signaling pathways, affect aging, reproduction, metabolism, development and immunity in mosquitoes. We are also looking to harness these signaling cascade as novel control strategies for mosquito-borne disease using cutting edge genetic manipulation strategies, including most recently CRISPR/Cas9.Show Less
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Courses
- MISMethods in Insect Science
- ISBInsect Systems Biology
- MVEMedical-Veterinary Entomology
Grants
- How to Starve a Parasite: Manipulating CoA Biosynthesis to Control Plasmodium Development in the Mosquito
Principal Investigator (PI)
2023
$622.5K
Active - Virus testing of Aedes aegypti pools for dengue surveillance
Co-Investigator (COI)
2021
$25.0K
- Assessing the Physiological Roles of Distinct Insulin-Like Peptides in the Mosquito Aedes Aegypti
Principal Investigator (PI)
2019
$422.1K
- Midgut Mitochondrial Function as a Driver of Resistance and Fitness in Mosquitoes
Principal Investigator (PI)
2018
$726.4K
- Impacts of Targeted Larviciding and ULV Adulticiding on the Vectorial Capacity of the Zika Vector, Aedes Aegypti
Co-Investigator (COI)
2017
$1.3M
- Midgut Mitochondria as The Key to Fit, Plasmodium-Resistant Anopheline Mosquitoes
Principal Investigator (PI)
2017
$238.5K
- Improving Anopheline Fitness And Resistance Through Fat Body Insulin Signaling
Principal Investigator (PI)
2016
$422.5K
- RAPID: Determining the Extrinsic Incubation Period and Transovarial Transmission Potential of Zika Virus in Aedes Aegypti Mosquitoes
Principal Investigator (PI)
2016
$198.2K
- Midgut Mitochondria as the Key to Fit, Plasmodium-resistant Anopheline Mosquitoes
Principal Investigator (PI)
2016
$7.0K
- Harnessing Midgut Mitochondrial Dynamics to Enhance Anopheline Mosquito Fitness
Principal Investigator (PI)
2014
$193.1K
News
- 3 From UA Recognized by AAAS in New Class of Fellows
2018
- Bug Off! UA Scientists Study Mosquito Control
2017
- UA Experts Available for Comment on Zika Virus
2016
- Fighting Mosquitoes in Tucson and the Florida Keys
2012
- UA Team Receives $2.3M to Track Dengue Transmission
2012
- The First Malaria-Proof Mosquito
2010
- UA Entomologist Wins Grant to Develop Malaria-Resistant Mosquito
2009
Publications (87)
Recent
- Differences in Longevity and Temperature-Driven Extrinsic Incubation Period Correlate with Varying Dengue Risk in the Arizona–Sonora Desert Region
2023
- Genetic Variation in Rhipicephalus sanguineus s.l. Ticks across Arizona
2022
- Manipulation of pantothenate kinase in Anopheles stephensi suppresses pantothenate levels with minimal impacts on mosquito fitness
2022
- Predicting Age in Aedes aegypti (Diptera: Culicidae) Females to Monitor Changes in Transmission Potential
2022
- Using body size as an indicator for age structure in field populations of Aedes aegypti (Diptera: Culicidae)
2022
- Assessing Near-Infrared Spectroscopy (NIRS) for Evaluation of Aedes aegypti Population Age Structure
2022
- Activation of <i>Anopheles stephensi</i> Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse <i>Plasmodium</i> Species in the Mosquito Host
2021
- Increased insulin signaling in the Anopheles stephensi fat body regulates metabolism and enhances the host response to both bacterial challenge and Plasmodium falciparum infection
2021
- Activation of Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Species in the Mosquito Host
2021
- Overexpression of Activated AMPK in the Midgut Impacts Mosquito Metabolism, Reproduction and Resistance
2021
- Overexpression of Activated AMPK in the <i>Anopheles stephensi</i> Midgut Impacts Mosquito Metabolism, Reproduction and <i>Plasmodium</i> Resistance
2021
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
2021
- Impact of Zika virus vertical transmission in the mosquito Aedes aegypti
2020
- Vertical Transmission of Zika Virus in Aedes aegypti Produces Potentially Infectious Progeny
2020
- Size as a Proxy for Survival in Aedes aegypti (Diptera: Culicidae) Mosquitoes
2020
- Vertical Transmission of Zika Virus in Produces Potentially Infectious Progeny
2020
- Size as a Proxy for Longevity in Aedes aegypti (Diptera: Culicidae) Mosquitoe
2020
- Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito Host
2020
- Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides
2019
- Increased insulin signaling in the fat body of Anopheles stephensi mosquitoes extends lifespan through modulation of Insulin-like Peptides (ILP) expression leading to increased lifetime fecundity.
2019
- Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection
2018
- Vertical transmission of Zika virus in orally-infected Aedes aegypti produces infectious adult progeny
2018
- Effective Climate Communication: Using Data on the spread of Infectious Diseases to Improve Community Preparedness
2018
- Moderate inhibition of JNK extends longevity and improves resistance to Plasmodium falciparum infection in the Asian malaria vector Anopheles stephensi
2018
- The effects of temperature on the extrinisic incubation period of Zika virus in Aedes aegypti.
2018
- Vectors living at the ecological edge and the impact on human arbovirus transmission
2018
- Impact of increased AMP-activated protein kinase in the midgut of Anopheles stephensi on fitness and metabolism
2018
- MUVE Section Symposium: What Can We Learn About Vector-borne Diseases of Plants, Animals, and Humans From Talking to Each Other?
2018
- Conservation and convergence of immune signaling pathways with mitochondrial regulation in vector arthropod physiology
2017
- Assessing the impact of temperature on the extrinsic incubation period of Zika virus in Aedes aegypti
2017
- Aedes aegypti population age structure as a measure of vectorial capacity along the Arizona/Sonora border region
2017
- On the edge: Climatic influences on Ae. aegypti indices and dengue virus transmission in the Sonoran desert region
2016
- Symposium: Vertebrate Host Factors: Effect on Vector Biology
2016
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
2016
- Mitochondrial metabolism and the connections between physiology and immunity inAnophelesmosquitoes
2016
- Aedes aegypti(Diptera: Culicidae) Longevity and Differential Emergence of Dengue Fever in Two Cities in Sonora, Mexico
2016
- Guidelines for the use and interpretation of assays for monitoring autophagy
2016
- Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism
2016
- IMPACT OF INCREASED INSULIN SIGNALING IN THE FAT BODY OF ANOPHELES STEPHENSI AND AEDES AEGYPTI MOSQUITOES ON INNATE IMMUNITY, LIFESPAN AND REPRODUCTION
2015
- Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes
2015
- Plasmodium falciparum suppresses the host immune response by inducing the synthesis of insulin-like peptides (ILPs) in the mosquito Anopheles stephensi.
2015
- Highly evolvable malaria vectors: The genomes of 16Anophelesmosquitoes
2015
- Resveratrol Fails to Extend Life Span in the MosquitoAnopheles stephensi
2015
- Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
2014
- 11 Antipathogen Effector Molecules: Current and Future
2014
- Increased Akt signaling in the mosquito fat body increases adult survivorship
2014
- Effects of ingested vertebrate-derived factors on insect immune responses
2014
- Antipathogen effector molecules: current and future strategies.
2014
- Differential Emergence of Dengue in the Arizona-Sonora Desert Region: Understanding the Role of Social and Environmental Factors
2014
- Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi
2014
- Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi
2014
- Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host
2013
- Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi
2013
- Insulin-Like Peptides
2012
- Insulin-like peptides: structure, signaling, and function
2012
- Aging Field Collected Aedes aegypti to Determine Their Capacity for Dengue Transmission in the Southwestern United States
2012
- Ingested Human Insulin Inhibits the Mosquito NF-κB-Dependent Immune Response to Plasmodium falciparum
2012
- The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression
2011
- The Putative AKH Receptor of the Tobacco Hornworm,Manduca sexta, and Its Expression
2011
- Insulin-like peptides in the mosquito Anopheles stephensi: identification and expression in response to diet and infection with Plasmodium falciparum
2011
- Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes
2010
- The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti
2010
- Utilizing rabbit immunoglobulin G protein for mark-capture studies on the desert subterranean termite, Heterotermes aureus (Snyder)
2009
- Manipulating insulin signaling to enhance mosquito reproduction
2009
- Identification and characterization of the catalytic subunit of phosphatidylinositol 3-kinase in the yellow fever mosquito Aedes aegypti
2008
- Expression of a mutated phospholipase A2 in transgenic Aedes fluviatilis mosquitoes impacts Plasmodium gallinaceum development
2008
- The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection
2007
- Using bacteria to express and display anti-Plasmodium molecules in the mosquito midgut
2007
- Characterization of Phosphatase and Tensin Homolog expression in the mosquito Aedes aegypti: Six splice variants with developmental and tissue specificity
2007
- Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: expression, cellular localization, and phylogeny
2006
- Using bacteria to express and display anti-parasite molecules in mosquitoes: current and future strategies
2005
- Molecular characterization of insulin‐like peptide genes and their expression in the African malaria mosquito, Anopheles gambiae
2004
- Molecular analysis of the serine/threonine kinase Akt and its expression in the mosquito Aedes aegypti
2003
- Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges
2003
- Neuropeptides and peptide hormones in Anopheles gambiae
2002
- Characterization of the AeaHP Gene and its Expression in the Mosquito Aedes aegypti (Diptera: Culicidae)
2002
- Characterization of the <I>AeaHP</I> Gene and its Expression in the Mosquito <I>Aedes aegypti</I> (Diptera: Culicidae)
2002
- Insulin receptor expression during development and a reproductive cycle in the ovary of the mosquito Aedes aegypti
2002
- Characterization of the steroidogenic signaling cascade in the mosquito Aedes aegypti
2001
- Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti
1999
- A Factor Preventing Melanization of Sephadex CM C-25 Beads inPlasmodium-Susceptible and RefractoryAnopheles gambiae
1998
- Ixodes scapularis (Acari: Ixodidae): Status and Changes in Prevalence and Distribution in Wisconsin Between 1981 and 1994 Measured by Deer Surveillance
1996
- BIOCHEMICAL-ANALYSIS OF RESPONSES TO SEPHADEX C-25 BEADS IN PLASMODIUM-REFRACTORY AND SUSCEPTIBLE ANOPHELES-GAMBIAE
1995
- Effect of Mosquito Age and Reproductive Status on Melanization of Sephadex Beads in Plasmodium-Refractory and -Susceptible Strains of Anopheles gambiae
1995
- Effect of mosquito age and reproductive status on melanization of Sephadex Beads in Plasmodium-refractory and suscetible strains of Anopheles gambiae
1995
- Response of Plasmodium refractory and susceptible strains of Anopheles gambiae to inoculated Sephadex beads
1994