KMap
- BBiochemistry
- NAMNucleic Acids, Metabolism, and Signaling
- BSIBiological Structure I
- BSBiological Structure 1
- MBMetabolic Biochemistry
- Structural and Biochemical Studies of DYRK1A Kinase
2023
doctoral - Developing a screen to discover novel mRNA 3’-UTR-mediated scaffolding of protein- protein interactors
2022
bachelors - Functional Expression of Organic Cation Transporters at the Blood-Brain Barrier: Relevance to the Treatment of Ischemic Stroke
2022
bachelors - MECHANISMS UNDERLYING THE PROTECTIVE EFFECT OF GLYCOLYSIS
2022
bachelors - Determining CD47 Structure and Discerning Function to Understand Signal Transduction Mechanism
2021
doctoral - Allosteric Regulation of Soluble Guanylyl Cyclase: The Nitric Oxide Receptor
2018
doctoral - X-Ray Crystallographic Studies of Dyrk1a, a Kinase Linked to Down Syndrome
2017
bachelors - Uncovering Signal Transduction in Blood Pressure Regulation by Nitric Oxide
2017
bachelors - Mass Spectrometry: Toward Elucidating the Biosignature of Coccidioidomycosis and Insights into Surface Induced Dissociation of Biologically Relevant Carbohydrates
2016
doctoral - Angiotensin-(1-7) as an Antinociceptive Agent in Cancer-Induced Bone Pain
2015
bachelors - Structural Studies of Thioredoxin S-nitrosation and Detection of Protein S-nitrosothiols by Phosphine Derivatization
2014
doctoral - The Mechanism of Allosteric Regulation in Soluble Guanylate Cyclase
2014
doctoral
- A Nutrition and Exercise Prehabilitation Intervention on Inflammatory Biomarkers in American Indian Cancer Patients
Key Personnel (KP)
2023
$271.6KActive - Establishing a Pleiotropic Brain-Penetrant Small-Molecule to Impede Glioblastoma
Co-Investigator (COI)
2023
$180.7KActive - DYRK1A Inhibition as a Novel Treatment Approach for Alzheimer's Disease
Co-Investigator (COI)
2020
$3.0MActive - Chemistry-Biology Interface Training Program
Principal Investigator (PI)
2019
$1.5MActive - Addressing Breast Cancer Health Disparities in American Indians through Translational and Dissemination/Implementation Science (Diversity Supplement for Dr. Jennifer Erdrich - Cost Extension)
Key Personnel (KP)
2019
$346.2KActive - Structure and Stimulator Binding Mechanism of the Nitric Oxide Receptor, Soluble Guanylate Cyclase
Key Personnel (KP)
2017
$106.8K - University of Arizona Cancer Center - Cancer Center Support Grant
Key Personnel (KP)
2016
$26.3M - Soluble Guanylate Cyclase: A Therapeutic Target for Cardiovascular Pathology
Co-Investigator (COI)
2016
$50.3K - Nitric Oxide Signaling in Health and Disease
Principal Investigator (PI)
2015
$1.4M - Chemistry-Biology Interface Training Program
Principal Investigator (PI)
2014
$1.1M
- Researchers Paving the Way for New Heart Disease Treatments
2008
- Spotlight on Teaching: Wells Gives Students 3-D Understanding of Molecules
2000
- Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor
2023
- Abstract P5-10-08: Inflammation drives NOS2-Akt2 signaling in triple negative breast cancer
2022
- Solution structures of the Shewanella woodyi H‐NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP‐051
2021
- Resolving CD47 Structure and Function to Understand Signal Transduction Mechanism
2020
- SOLUTION STRUCTURE OF THE IWP-051-BOUND H-NOX FROM SHEWANELLA WOODYI REVEALS A CONSERVED BINDING POCKET FOR SOLUBLE GUANYLYL CYCLASE STIMULATORS
2019
- Instability in a coiled‐coil signaling helix is conserved for signal transduction in soluble guanylyl cyclase
2019
- Method for detecting crosslinked peptides via reproducible fragmentation in a mass spectrometer
2019
- Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants
2019
- Unloading the left ventricle before reperfusion in patients with anterior ST-segment–elevation myocardial infarction: a pilot study using the Impella CP
2019
- Detectable IgG against a Cimex lectularius allergen after a report of bed bug bites among NYC children
2019
- How stimulator compounds and nitric oxide bind and stimulate soluble guanylyl cyclase GC1)
2019
- Novel nitric oxide-liberating heme proteins from the saliva of bloodsucking insects
2018
- Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase
2018
- MetaUniDec: high-throughput deconvolution of native mass spectra
2018
- Blocking “don't eat me” signal of CD47-SIRPα in hematological malignancies, an in-depth review
2018
- Characterizing the CD47/TSP-1 Signaling Axis
2018
- A sporadic case of severe peripheral neuropathy expands the phenotypic range of TUBB2A mutations.
2017
- Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor
2016
- Localizing Stimulator Binding to the beta 1 H-NOX Domain of Soluble Guanylate Cyclase
2016
- Determining Nitric Oxide‐induced Conformational Changes in Soluble Guanylate Cyclase using Lanthanide‐based Resonance Energy Transfer
2016
- Uncovering Stimulator Binding Mechanism to Soluble Guanylyl Cyclase by Solution NMR
2016
- Heat shock protein 90 associates with the Per-Arnt-Sim domain of heme-free soluble guanylate cyclase: implications for enzyme maturation
2015
- Dimerization of nitrophorin 4 at low pH and comparison to the K1A mutant of nitrophorin 1
2015
- Development of IgE against a Cimex lectularius allergen after being bitten by bed bugs was common among children in NYC
2014
- YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit
2014
- Evolution in an ancient detoxification pathway is coupled with a transition to herbivory in the drosophilidae
2014
- Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking
2013
- YC‑1 Binding to the β Subunit of Soluble Guanylyl Cyclase Overcomes Allosteric Inhibition by the α Subunit
2013
- pH-dependent picosecond structural dynamics in the distal pocket of nitrophorin 4 investigated by 2D IR spectroscopy
2013
- Structural Studies of Thioredoxin S-nitrosation and Detection of Protein S-nitrosothiols by Phosphine Derivatization
2013
- Crystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclase
2013
- Rational reprogramming of fungal polyketide first-ring cyclization
2013
- Nitric Oxide Signaling with Heme Proteins
2012
- Structural and Functional Studies on the Nitric Oxide Receptor: YC-1 Binding to the PAS Domain of Soluble Guanylate Cyclase
2012
- Thrombospondin-1 Binding to CD47 in the Regulation of Nitric Oxide Signaling
2012
- IgE against bed bug Cimex lectularius) allergens is common among adults bitten by bed bugs
2012
- Distal pocket and belt side chain effects on the stabilization of the ferric-NO heme center of the Nitrophorins of Rhodnius prolixus
2011
- Oxidation and Loss of Heme in Soluble Guanylyl Cyclase from Manduca sexta
2011
- Crystal structures of multicopper oxidase CueO bound to copper I) and silver I) functional role of a methionine-rich sequence
2011
- Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration
2011
- The Reaction of HNO Donors with Heme Proteins
2010
- Activation mechanism of soluble guanylate cyclase: New insights from the resonance Raman studies of a truncated insect protein
2010
- Model for Truncated Soluble Guanylate Cyclase by Negative Stain Electron Microscopy: 384
2010
- Ultrafast dynamics of diatomic ligand binding to nitrophorin 4
2010
- Investigating shape and mechanism of soluble guanylate cyclase: 383
2010
- Crystal structure of human thioredoxin revealing an unraveled helix and exposed S‐nitrosation site
2010
- NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1NM23-H2 and c-Myc Activation
2009
- Crystal structure of the bacterial luciferase/flavin complex provides insight into the function of the β subunit
2009
- NITRIC OXIDE SIGNALING IN BLOOD‐SUCKING INSECTS, HORNWORMS AND HUMANS
2009
- Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and …
2009
- A New Use for a Familiar Fold: The X-ray Crystal Structure of GTP-Bound GTP Cyclohydrolase III from Methanocaldococcus jannaschii Reveals a Two Metal Ion Catalytic …
2008
- N15 Cro and λ Cro: Orthologous DNA‐binding domains with completely different but equally effective homodimer interfaces
2008
- Allostery in recombinant soluble guanylyl cyclase from Manduca sexta
2008
- Low-frequency mode activity of heme: femtosecond coherence spectroscopy of iron porphine halides and nitrophorin
2008
- Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds
2008
- Binding of YC-1 or BAY 41-2272 to soluble guanylyl cyclase induces a geminate phase in CO photolysis
2008
- Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant
2008
- X-ray Structure of Cerulean GFP: A Tryptophan-Based Chromophore Useful for Fluorescence Lifetime Imaging,
2007
- Apo‐nitrophorin 4 at atomic resolution
2007
- Buried S-Nitrosocysteine Revealed in Crystal Structures of Human Thioredoxin,
2007
- S-nitrosylation-induced conformational change in blackfin tuna myoglobin
2007
- Nonequilibrium dynamics simulations of nitric oxide release: comparative study of nitrophorin and myoglobin
2007
- Assignment of the Ferriheme Resonances of the Low-Spin Complexes of Nitrophorins 1 and 4 by 1H and 13C NMR Spectroscopy: Comparison to Structural Data …
2007
- Microsystems for UV-visible and x-ray analysis of protein crystals
2007
- O19. Crystal structures of S-nitrosated thioredoxin
2006
- Structural characterization of R. prolixus nitrophorin 4 by UV and visible resonance Raman spectroscopy
2006
- O11. HNO donors and heme proteins
2006
- Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity
2006
- SYMPOSIUM LECTURES-Nitrosyl heme and S-nitrosation in nitric oxide signaling
2006
- Structure of the Y94F mutant of Escherichia coli thymidylate synthase
2006
- P062. NO and GSNO stimulation of recombinant soluble guanylate cyclase from Manduca sexta
2006
- A Novel Copper-Binding Fold for the Periplasmic Copper Resistance Protein CusF,
2005
- 5, 10-Methylene-5, 6, 7, 8-tetrahydrofolate conformational transitions upon binding to thymidylate synthase: molecular mechanics and continuum solvent studies
2005
- Ultrahigh Resolution Structures of Nitrophorin 4: Heme Distortion in Ferrous CO and NO Complexes,
2005
- Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein
2005
- Loodynamics and function in nitrophorin 4
2004
- Resonance Raman spectroscopic study of nitrophorin 2 from Rhodnius prolixus kissing bug and its mutants
2004
- Cuprous Oxidase Activity of CueO from Escherichia coli
2004
- Protein and ligand induced heme distortion in the nitrophorins
2004
- Role of Binding Site Loops in Controlling Nitric Oxide Release: Structure and Kinetics of Mutant Forms of Nitrophorin 4,
2004
- Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole …
2004
- Structural dynamics controls nitric oxide affinity in nitrophorin 4
2004
- HEME DEFORMATION AND A NOVEL HEME-ASSISTED NITROSILATION OF A THIOLATE LIGAND IN NITROPHORINS FROM BLOOD-SUCKING INSECTS
2004
- Heme ruffling in nitrophorin 4, a NO transport protein from Rhodnius prolixus
2004
- Protein Functional Cycle Viewed at Atomic Resolution: Conformational Change and Mobility in Nitrophorin 4 as a Function of pH and NO Binding,
2004
- Cimex lectularius nitrophorin characterized by resonance Raman spectroscopy
2004
- Nitric oxide transport by blood-sucking insects: Structure and dynamics
2003
- A labile regulatory copper ion lies near the T1 copper site in the multicopper oxidase CueO
2003
- Complementing thymidylate synthase
2003
- Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif
2003
- Nitrophorins: Lipocalin‐based heme proteins transporting nitric oxide
2002
- Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli
2002
- Blocking ligand escape with a stochastic gate in nitrophorin-NO complex
2002
- INSECT Rhodnius prolixus
2001
- Spectroelectrochemical studies of nitrophorin mutants: The importance of the carboxylates near the heme.
2001
- Ligand-Induced Heme Ruffling and Bent NO Geometry in Ultra-High-Resolution Structures of Nitrophorin 4,
2001
- Resonance Raman Spectroscopic Study of Nitrophorin 1, a Nitric Oxide-Binding Heme Protein from Rhodnius prolixus, and Its Nitrosyl and Cyano Adducts
2001
- Properties and biological activities of thioredoxins
2001
- Nitric oxide transport by a blood-sucking insect: Nitrophorin structure, dynamics, and distal pocket burial
2000
- Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial
2000
- The crystal structure of Nitrophorin 2: A trifunctional antihemostatic protein from the saliva of Rhodnius prolixus
2000
- Nitrophorins and related antihemostatic lipocalins from Rhodnius prolixus and other blood-sucking arthropods
2000
- Kinetics and equilibria in ligand binding by nitrophorins 1− 4: Evidence for stabilization of a nitric oxide− ferriheme complex through a ligand-induced conformational trap
2000
- The nitric oxide-releasing heme proteins from the saliva of the blood-sucking insect Rhodnius prolixus
2000
- α-Cyclodextrin extracts diacylglycerol from insect high density lipoproteins
2000
- THE NITRIC OXIDE-RELEASING HEME PROTEINS
2000
- Structure and reactivity of nitrophorins from a blood-sucking insect
1999
- Structural, spectroscopic and electrochemical comparison of three of the four nitrophorins NO-releasing heme proteins) from the saliva of the blood-sucking insect, Rhodnius …
1999
- In vivo inhibition of histamine-induced vascular leaks with kissing bug R prolixus) salivary protein NP4.
1999
- Nitric oxide binding to the ferri-and ferroheme states of nitrophorin 1, a reversible NO-binding heme protein from the saliva of the blood-sucking insect, Rhodnius prolixus
1999
- Crystal Structures of Rat Thymidylate Synthase Inhibited by Tomudex, a Potent Anticancer Drug,
1999
- Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase
1998
- Crystal structures of a nitric oxide transport protein from a blood-sucking insect
1998
- The crystal structure of nitrophorin 4 at 1.5 Å resolution: transport of nitric oxide by a lipocalin-based heme protein
1998
- Human Thioredoxin Homodimers: Regulation by pH, Role of Aspartate 60, and Crystal Structure of the Aspartate 60 → Asparagine Mutant,
1997
- Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate
1997
- Reversible no-carrying heme proteins from the saliva of bloodsucking insects.
1997
- Nitric Oxide Binding and Crystallization of Recombinant Nitrophorin I, a Nitric Oxide Transport Protein from the Blood-Sucking Bug Rhodnius prolixus
1997
- Thymidylate synthase: structure, inhibition, and strained conformations during catalysis
1997
- Crystal structures of a marginally active thymidylate synthase mutant, Arg 126→ Glu
1997
- Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73→ Ser mutation
1996
- Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer
1996
- Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
1995
- Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancerdrug 1843U89
1995
- Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase …
1995
- Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex
1994
- Binding by Thymidylate Synthase1
1990
- Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate
1990
- Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase
1990
- Segmental accommodation: A novel conformational change induced upon ligand binding by thymidylate synthase
1990
- Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases
1990
- The three-dimensional structure of ricin at 2.8 A.
1987
- Atomic structure of thymidylate synthase: target for rational drug design
1987
- X-ray crystallographic studies on the toxic protein ricin
1985
- Coordination chemistry of alkali and alkaline earth cations: Synthesis and X-ray crystal structure of cesium picrate)benzo-15-crown-5) Cs+ C 6 H 2 N 3 O 7−(C 14 H 20 O 5)
1985
- THE X-RAY STRUCTURE OF RICIN AND IMPLICATIONS FOR IMMUNOTOXIN DESIGN
1984