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Dr. Minying Cai is currently a research professor in the Department of Chemistry and Biochemistry at the University of Arizona. She has been working in the Chemistry & Biochemistry department for more than 16 years and has more than 100 publications in the area of novel drug discovery for obesity, diabetes, cancer and pain. Dr. Cai received the Ph.D. at the University of Arizona in Biochemistry and Molecular Biophysics in 2004. Before that, she had been working in Shanghai Institute of Materia Medica; Shanghai Research Center of Biotechnology in Chinese Academy of Sciences. Dr. Cai has been working on peptide based drug discovery for more than 23 years, starting with discovery of developing anti-microbial peptide and insulin related peptide drug. Sixteen years ago, she started working on melanotropin and opioid related drug discovery. Dr. Cai's research in peptides involves highly multidisciplinary areas including chemistry and biochemistry; molecular pharmacology, molecular imaging, and cancer research, with expertise in molecular pharmacology, synthetic, organic and peptide methodology, chemical and biophysical analysis and evaluation, and in vitro and in vivo expression. Dr. Cai is currently working on several projects at the interface of chemistry, pharmacology and biology within the areas of: 1. Structure based drug design and synthesis of GPCR ligands, including developing selective hMCRs ligand; 2. Developing novel biophysics tools for molecular imaging; novel biomarker for high-throughput screening system. 3. Exploiting novel scaffold via computational chemistry for small molecule therapeutics for energy balance and cancer study; 4. Creating a nanostructured integrated platform for biodetection and imaging-guided therapy. Keywords: Drug Discovery, Melanoma Prevention, neurodegenerative diseases, Obesity and Diabetes, Melanocortin System
Student Thesis/Dissertation
  • DEVELOPMENT AND EVALUATION OF SELECTIVE MELANOTROPINS OF CYCLIZED STRUCTURES, AND SMALL MOLECULE DERIVATIVES OF PIPERINE FOR MELANOMA CELL DEATH

    2016

    Bachelors
  • Melanocortin Peptide Drug Design and Application to Feeding Behavior and Melanoma

    2015

    bachelors
Grants
  • Funding agency logo
    Bioassay of melanocortin compounds

    Principal Investigator (PI)

    2019

    $50.0K
  • Funding agency logo
    Designing Novel Melanotropins for New Applications for the Melanocortin System

    Co-Investigator (COI)

    2014

    $1.2M
  • Funding agency logo
    Imaging Agents for the Detection of Cancer

    Co-Investigator (COI)

    2012

    $33.3K
Technologies / Patents
      News
      • UArizona Reports Record Number of Startups for Fiscal Year 2020

        2020

      • Startup Licenses Invention to Enhance Skin Cancer Prevention

        2018

      • TLA Sets Performance Records in 3rd Full Year

        2016

      • Startup Licenses UA Technology Targeting Depression

        2016

      • Program Preps UA Inventions for Market

        2016

      • UA Researchers Study Use of Peptide Hormones in Treating Disease

        2005

      Publications (4)
      • Development of i>N<i>Acetylated Dipalmitoyl-i>S<i>Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

        2019

      • Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles

        2013

      • Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells

        2009

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