KMap

Photo of Katrina Miranda(kmiranda)

Katrina Miranda

Associate Professor, BIO5 Institute,
Associate Professor, Chemistry and Biochemistry-Sci,
Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
kmiranda@arizona.edu
520/626-3655
UAVitae logogoogle scholar logoOrcid logo
Grant: $3.0M
Katrina Miranda experts in biochemistry, organic chemistry, environmental chemistry, oxidative stress, nitric oxide, bioinorganic chemistry, pharmacology, molecular biology, cardiovascular physiology, bioinformatics, catalysis, environmental nanotechnology, microbiology, inorganic chemistry, chemical biology, chemistry, spectroscopy, neuroscience, cytotoxicity, biogeochemistry, biophysics, cardiology, enzymology, genomics, biomaterials, tissue engineering, organometallic chemistry, photochemistry, cell death, immunology, microbial pathogenesis, cardiac arrhythmias, cell biology, computational biology, systems biology, geochemistry, petrology, inflammatory bowel disease, redox signaling, physical chemistry, heterogeneous catalysis, computational chemistry, molecular modeling, analytical chemistry, anesthesiology, medicinal chemistry, regenerative medicine, drug delivery, biostatistics, cardiac physiology
Courses
General Chemistry I 
Inorganic Chemistry 
Current Topics in Inorganic Research 
Inorganic Chemistry II 
Honors Fundamentals of Chemistry 
Advanced Inorganic Chemistry 
Recent Grants
Logo of Supporting Success of Science Transfer Students funding agency
2018 $999.6KActive
Supporting Success of Science Transfer Students
Logo of REU Site: Collaborative Research in the Chemical Sciences at the University Of Arizona funding agency
2009 $226.8K
REU Site: Collaborative Research in the Chemical Sciences at the University Of Arizona
Logo of HNO-Donating Prodrugs for Use as Pharmaceuticals and Biomedical Research Tools funding agency
2009 $54.2K
HNO-Donating Prodrugs for Use as Pharmaceuticals and Biomedical Research Tools
Logo of Arizona Partners in Science Award funding agency
2009 $15.0K
Arizona Partners in Science Award
Logo of CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry Under Biologically Relevant Conditions funding agency
2007 $585.0K
CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry Under Biologically Relevant Conditions
Logo of Assessment of the Chemical Biology of HNO via New Donors funding agency
2006 $1.1M
Assessment of the Chemical Biology of HNO via New Donors
Technologies / Patents
Logo of Compositions And Methods Of Diazeniumdiolate-Based Prodrugs For Treating Cancer
2019Compositions And Methods Of Diazeniumdiolate-Based Prodrugs For Treating Cancer 
Logo of Nitroxyl (HNO) Releasing Compounds and Uses Thereof in Treating Diseases
2014Nitroxyl (HNO) Releasing Compounds and Uses Thereof in Treating Diseases 
Logo of Nitroxyl (HNO) Releasing Compounds and Uses Thereof in Treating Diseases
1899Nitroxyl (HNO) Releasing Compounds and Uses Thereof in Treating Diseases 
Logo of Compositions and Methods of Diazeniumdiolate-Based Prodrugs for Treating Cancer
1899Compositions and Methods of Diazeniumdiolate-Based Prodrugs for Treating Cancer 
News
2013Google Awards Grant for UA-Developed Online Chemistry Course  
2013Three UA Professors Elected as AAAS Fellows 
2009Chemistry Professor Honored in Washington, D.C. 
2004Eminent Scholar Series  
Publications (80)
Recent
2022HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation 
2021Nitric Oxide and Cancer: When to Give and When to Take Away? 
2019Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance 
2016Special issue in honour of Prof. Peter C. Ford 
2015Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast Cancer 
2015Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion 
2014Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway 
2014Persulfides and the cellular thiol landscape 
2014Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways 
2014Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates 
2014Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film 
2013The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats 
2013Biological nitric oxide signalling: Chemistry and terminology 
2013Mechanisms of nitric oxide reactions mediated by biologically relevant metal centers 
2013Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives 
2013Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent 
2011HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH 
2011The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems 
2010Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class 
2010The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O sub 2 /sub sup .- /sup is alive and well 
2010Reactions of HNO with heme proteins: New routes to HNO-heme complexes and insight into physiological effects 
2009Comparing the chemical biology of NO and HNO 
2009The emergence of nitroxyl (HNO) as a pharmacological agent 
2009The effects of nitroxyl (HNO) on soluble guanylate cyclase activity. Interactions at ferrous heme and cysteine thiols 
2009Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications 
2008The inducing NO-vasodilation by chemical reduction of coordinated nitrite ion in cis-[Ru(NO sub 2 /sub )L(bpy) sub 2 /sub ] sup + /sup complex 
2008Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine 
2008Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide 
2008Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses 
2007The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO sup 1 /sup 1This review is dedicated to the career of Prof. Herbert T. Nagasawa, a pioneer in the field of HNO chemistry, biochemistry and pharmacology. 
2006Discriminating formation of HNO from other reactive nitrogen oxide species 
2006Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations 
2006Peroxynitrite and myocardial contractility: In vivo versus in vitro effects 
2006The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling 
2005Donors of HNO 
2005Nitroxyl (HNO): Chemistry, biochemistry, and pharmacology 
2005The chemistry of nitroxyl (HNO) and implications in biology 
2005Comparison of the chemical biology of NO and HNO: An inorganic perspective 
2004The chemical dynamics of NO and reactive nitrogen oxides: A practical guide 
2004Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between sup • /sup NO and oxidative stress 
2004The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations 
2003Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species 
2003Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: A novel redox paradigm 
2003Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning 
2003Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins: A chemical discussion of the differential biological effects of these redox related products of NOS 
2003Positive inotropic and lusitropic effects of HNO/NO sup - /sup in failing hearts: Independence from β-adrenergic signaling 
2003Heme proteins and nitric oxide (NO): The neglected, eloquent chemistry in NO redox signaling and regulation 
2003Nitric oxide-induced cellular stress and p53 activation in chronic inflammation 
2002Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: Effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite 
2002Ingress and reactive chemistry of nitroxyl-derived species within human cells 
2002Comparison of the NO and HNO donating properties of diazeniumdiolates: Primary amine adducts release HNO in vivo 
2002Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins - A chemical discussion of the differential biological effects of these redox related products of NOS 
2002Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O sub 2 /sub sup - /sup reaction 
2002A chemical perspective on the interplay between NO, reactive oxygen species, and Reactive Nitrogen Oxide Species 
2002Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms 
2002Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH 
2002Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems 
2001The reduction potential of nitric oxide (NO) and its importance to NO biochemistry 
2001Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion 
2001Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O-2(-) reaction 
2001Nitroxyl anion regulation of the NMDA receptor 
2001Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling 
2001Distinction between Nitrosating Mechanisms within Human Cells and Aqueous Solution 
2001Cytotoxicity related to oxidative and nitrosative stress by nitric oxide 
2001The oxidative and nitrosative chemistry of the nitric oxide superoxide reaction in the presence of bicarbonate 
2001Mechanisms of the antioxidant effects of nitric oxide 
2001Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: Insights into Listeriocidal activity of oxidative and nitrosative stress 
2000A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system 
2000Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals 
2000A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity 
2000Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from beta-adrenergic signaling 
2000Inhibitory effects of nitric oxide and nitrosative stress on dopamine- β-hydroxylase 
2000Effects of oxidative and nitrosative stress in cytotoxicity 
1999Mechanisms of cell death governed by the balance between nitrosative and oxidative stress 
1999The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate 
1998Flash photolysis studies of the ruthenium(II) porphyrins RU(P)(NO)(ONO). Multiple pathways involving reactions of intermediates with nitric oxide 
1998Photochemistry of metal nitrosyl complexes. Delivery of nitric oxide to biological targets 
1998A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite 
1997Synthesis and Structural Characterization of Several Ruthenium Porphyrin Nitrosyl Complexes 
1997Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide 
Grants
Citations
H-Index
Tech
Patents
News
Books
Opportunities