Courses
- ICInorganic Chemistry
- AICAdvanced Inorganic Chemistry
- CTICurrent Topics in Inorganic Research
- HFCHonors Fundamentals of Chemistry
- ICIInorganic Chemistry II
- GCIGeneral Chemistry I
Student Thesis/Dissertation
- Reactivity and Mechanistic Aspects of NO and HNO Donors
2014
doctoral
Grants
- MARC Biomedical Research and Training Program at the University of Arizona
Principal Investigator (PI)
2023
$266.2KActive - Supporting Success of Science Transfer Students
Principal Investigator (PI)
2018
$999.6KActive - REU Site: Collaborative Research in the Chemical Sciences at the University Of Arizona
Principal Investigator (PI)
2009
$226.8K - HNO-Donating Prodrugs for Use as Pharmaceuticals and Biomedical Research Tools
Co-Investigator (COI)
2009
$54.2K - Arizona Partners in Science Award
Principal Investigator (PI)
2009
$15.0K - CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry Under Biologically Relevant Conditions
Principal Investigator (PI)
2007
$585.0K - Assessment of the Chemical Biology of HNO via New Donors
Principal Investigator (PI)
2006
$1.1M
Technologies / Patents
News
- Google Awards Grant for UA-Developed Online Chemistry Course
2013
- Three UA Professors Elected as AAAS Fellows
2013
- Chemistry Professor Honored in Washington, D.C.
2009
- Eminent Scholar Series
2004
Publications (79)
Recent
- HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation
2022
- Nitric Oxide and Cancer: When to Give and When to Take Away?
2021
- Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance
2019
- Special issue in honour of Prof. Peter C. Ford
2016
- Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion
2015
- Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast Cancer
2015
- Persulfides and the cellular thiol landscape
2014
- Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways
2014
- Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film
2014
- Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway
2014
- Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates
2014
- The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats
2013
- Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives
2013
- Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent
2013
- Mechanisms of nitric oxide reactions mediated by biologically relevant metal centers
2013
- Biological nitric oxide signalling: Chemistry and terminology
2013
- The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems
2011
- HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH
2011
- Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate NONOate) class
2010
- Reactions of HNO with heme proteins: New routes to HNO-heme complexes and insight into physiological effects
2010
- The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O sub 2 sub su. su is alive and well
2010
- Comparing the chemical biology of NO and HNO
2009
- The effects of nitroxyl HNO) on soluble guanylate cyclase activity. Interactions at ferrous heme and cysteine thiols
2009
- The emergence of nitroxyl HNO) as a pharmacological agent
2009
- Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications
2009
- Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl HNO) in the presence of endogenous nitric oxide
2008
- The inducing NO-vasodilation by chemical reduction of coordinated nitrite ion in cis-Ru(NO sub 2 sub L(bpy) sub 2 sub su+ su complex
2008
- Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses
2008
- Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine
2008
- The pharmacology of nitroxyl HNO) and its therapeutic potential: Not just the janus face of NO su1 su1This review is dedicated to the career of Prof. Herbert T. Nagasawa, a pioneer in the field of HNO chemistry, biochemistry and pharmacology.
2007
- Peroxynitrite and myocardial contractility: In vivo versus in vitro effects
2006
- Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations
2006
- Discriminating formation of HNO from other reactive nitrogen oxide species
2006
- The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling
2006
- The chemistry of nitroxyl HNO) and implications in biology
2005
- Nitroxyl HNO) Chemistry, biochemistry, and pharmacology
2005
- Comparison of the chemical biology of NO and HNO: An inorganic perspective
2005
- The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
2004
- Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between su• suNO and oxidative stress
2004
- The chemical dynamics of NO and reactive nitrogen oxides: A practical guide
2004
- Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning
2003
- Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
2003
- Inhibition of poly(ADP-ribose) polymerase PARP) by nitric oxide and reactive nitrogen oxide species
2003
- Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: A novel redox paradigm
2003
- Positive inotropic and lusitropic effects of HNO/NO su- su in failing hearts: Independence from β-adrenergic signaling
2003
- Heme proteins and nitric oxide NO) The neglected, eloquent chemistry in NO redox signaling and regulation
2003
- A chemical perspective on the interplay between NO, reactive oxygen species, and Reactive Nitrogen Oxide Species
2002
- Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms
2002
- Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O sub 2 sub su- su reaction
2002
- Mechanism of aerobic decomposition of Angeli's salt sodium trioxodinitrate) at physiological pH
2002
- Ingress and reactive chemistry of nitroxyl-derived species within human cells
2002
- Comparison of the NO and HNO donating properties of diazeniumdiolates: Primary amine adducts release HNO in vivo
2002
- Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: Effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite
2002
- Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion
2001
- Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: Insights into Listeriocidal activity of oxidative and nitrosative stress
2001
- The reduction potential of nitric oxide NO) and its importance to NO biochemistry
2001
- The oxidative and nitrosative chemistry of the nitric oxide superoxide reaction in the presence of bicarbonate
2001
- Mechanisms of the antioxidant effects of nitric oxide
2001
- Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O-2( reaction
2001
- Nitroxyl anion regulation of the NMDA receptor
2001
- Distinction between Nitrosating Mechanisms within Human Cells and Aqueous Solution
2001
- Inhibitory effects of nitric oxide and nitrosative stress on dopamine- β-hydroxylase
2000
- Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals
2000
- A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity
2000
- Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from beta-adrenergic signaling
2000
- A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
2000
- Effects of oxidative and nitrosative stress in cytotoxicity
2000
- Mechanisms of cell death governed by the balance between nitrosative and oxidative stress
1999
- The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate
1999
- Flash photolysis studies of the ruthenium(II) porphyrins RU(P)NO)ONO) Multiple pathways involving reactions of intermediates with nitric oxide
1998
- Photochemistry of metal nitrosyl complexes. Delivery of nitric oxide to biological targets
1998
- A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
1998
- Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide
1997
- Synthesis and Structural Characterization of Several Ruthenium Porphyrin Nitrosyl Complexes
1997
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