KMap
Courses
  • IC
    Inorganic Chemistry

  • AIC
    Advanced Inorganic Chemistry

  • CTI
    Current Topics in Inorganic Research

  • HFC
    Honors Fundamentals of Chemistry

  • ICI
    Inorganic Chemistry II

  • GCI
    General Chemistry I

Student Thesis/Dissertation
  • Reactivity and Mechanistic Aspects of NO and HNO Donors

    2014

    doctoral
Grants
  • Funding agency logo
    MARC Biomedical Research and Training Program at the University of Arizona

    Principal Investigator (PI)

    2023

    $266.2K
    Active
  • Funding agency logo
    Supporting Success of Science Transfer Students

    Principal Investigator (PI)

    2018

    $999.6K
    Active
  • Funding agency logo
    REU Site: Collaborative Research in the Chemical Sciences at the University Of Arizona

    Principal Investigator (PI)

    2009

    $226.8K
  • Funding agency logo
    HNO-Donating Prodrugs for Use as Pharmaceuticals and Biomedical Research Tools

    Co-Investigator (COI)

    2009

    $54.2K
  • Funding agency logo
    Arizona Partners in Science Award

    Principal Investigator (PI)

    2009

    $15.0K
  • Funding agency logo
    CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry Under Biologically Relevant Conditions

    Principal Investigator (PI)

    2007

    $585.0K
  • Funding agency logo
    Assessment of the Chemical Biology of HNO via New Donors

    Principal Investigator (PI)

    2006

    $1.1M
Technologies / Patents
      News
      • Google Awards Grant for UA-Developed Online Chemistry Course

        2013

      • Three UA Professors Elected as AAAS Fellows

        2013

      • Chemistry Professor Honored in Washington, D.C.

        2009

      • Eminent Scholar Series

        2004

      Publications (79)
      Recent
      • HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

        2022

      • Nitric Oxide and Cancer: When to Give and When to Take Away?

        2021

      • Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance

        2019

      • Special issue in honour of Prof. Peter C. Ford

        2016

      • Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion

        2015

      • Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast Cancer

        2015

      • Persulfides and the cellular thiol landscape

        2014

      • Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways

        2014

      • Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film

        2014

      • Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

        2014

      • Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates

        2014

      • The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats

        2013

      • Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives

        2013

      • Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent

        2013

      • Mechanisms of nitric oxide reactions mediated by biologically relevant metal centers

        2013

      • Biological nitric oxide signalling: Chemistry and terminology

        2013

      • The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems

        2011

      • HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH

        2011

      • Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate NONOate) class

        2010

      • Reactions of HNO with heme proteins: New routes to HNO-heme complexes and insight into physiological effects

        2010

      • The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O sub 2 sub su. su is alive and well

        2010

      • Comparing the chemical biology of NO and HNO

        2009

      • The effects of nitroxyl HNO) on soluble guanylate cyclase activity. Interactions at ferrous heme and cysteine thiols

        2009

      • The emergence of nitroxyl HNO) as a pharmacological agent

        2009

      • Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications

        2009

      • Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl HNO) in the presence of endogenous nitric oxide

        2008

      • The inducing NO-vasodilation by chemical reduction of coordinated nitrite ion in cis-Ru(NO sub 2 sub L(bpy) sub 2 sub su+ su complex

        2008

      • Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses

        2008

      • Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine

        2008

      • The pharmacology of nitroxyl HNO) and its therapeutic potential: Not just the janus face of NO su1 su1This review is dedicated to the career of Prof. Herbert T. Nagasawa, a pioneer in the field of HNO chemistry, biochemistry and pharmacology.

        2007

      • Peroxynitrite and myocardial contractility: In vivo versus in vitro effects

        2006

      • Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations

        2006

      • Discriminating formation of HNO from other reactive nitrogen oxide species

        2006

      • The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling

        2006

      • The chemistry of nitroxyl HNO) and implications in biology

        2005

      • Nitroxyl HNO) Chemistry, biochemistry, and pharmacology

        2005

      • Comparison of the chemical biology of NO and HNO: An inorganic perspective

        2005

      • The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations

        2004

      • Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between su• suNO and oxidative stress

        2004

      • The chemical dynamics of NO and reactive nitrogen oxides: A practical guide

        2004

      • Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning

        2003

      • Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

        2003

      • Inhibition of poly(ADP-ribose) polymerase PARP) by nitric oxide and reactive nitrogen oxide species

        2003

      • Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: A novel redox paradigm

        2003

      • Positive inotropic and lusitropic effects of HNO/NO su- su in failing hearts: Independence from β-adrenergic signaling

        2003

      • Heme proteins and nitric oxide NO) The neglected, eloquent chemistry in NO redox signaling and regulation

        2003

      • A chemical perspective on the interplay between NO, reactive oxygen species, and Reactive Nitrogen Oxide Species

        2002

      • Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms

        2002

      • Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O sub 2 sub su- su reaction

        2002

      • Mechanism of aerobic decomposition of Angeli's salt sodium trioxodinitrate) at physiological pH

        2002

      • Ingress and reactive chemistry of nitroxyl-derived species within human cells

        2002

      • Comparison of the NO and HNO donating properties of diazeniumdiolates: Primary amine adducts release HNO in vivo

        2002

      • Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: Effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite

        2002

      • Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion

        2001

      • Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: Insights into Listeriocidal activity of oxidative and nitrosative stress

        2001

      • The reduction potential of nitric oxide NO) and its importance to NO biochemistry

        2001

      • The oxidative and nitrosative chemistry of the nitric oxide superoxide reaction in the presence of bicarbonate

        2001

      • Mechanisms of the antioxidant effects of nitric oxide

        2001

      • Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O-2( reaction

        2001

      • Nitroxyl anion regulation of the NMDA receptor

        2001

      • Distinction between Nitrosating Mechanisms within Human Cells and Aqueous Solution

        2001

      • Inhibitory effects of nitric oxide and nitrosative stress on dopamine- β-hydroxylase

        2000

      • Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals

        2000

      • A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity

        2000

      • Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from beta-adrenergic signaling

        2000

      • A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

        2000

      • Effects of oxidative and nitrosative stress in cytotoxicity

        2000

      • Mechanisms of cell death governed by the balance between nitrosative and oxidative stress

        1999

      • The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate

        1999

      • Flash photolysis studies of the ruthenium(II) porphyrins RU(P)NO)ONO) Multiple pathways involving reactions of intermediates with nitric oxide

        1998

      • Photochemistry of metal nitrosyl complexes. Delivery of nitric oxide to biological targets

        1998

      • A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite

        1998

      • Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide

        1997

      • Synthesis and Structural Characterization of Several Ruthenium Porphyrin Nitrosyl Complexes

        1997

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