KMap

Katrina Miranda

Associate Professor, BIO5 Institute,

Associate Professor, Chemistry and Biochemistry-Sci,

Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
kmiranda@arizona.edu

520/626-3655

Grant: $3.0M

Katrina Miranda experts in biochemistry, organic chemistry, environmental chemistry, oxidative stress, nitric oxide, bioinorganic chemistry, pharmacology, molecular biology, cardiovascular physiology, bioinformatics, catalysis, environmental nanotechnology, microbiology, inorganic chemistry, chemical biology, chemistry, spectroscopy, neuroscience, cytotoxicity, biogeochemistry, biophysics, cardiology, enzymology, genomics, biomaterials, tissue engineering, organometallic chemistry, photochemistry, cell death, immunology, microbial pathogenesis, cardiac arrhythmias, cell biology, computational biology, systems biology, geochemistry, petrology, inflammatory bowel disease, redox signaling, physical chemistry, heterogeneous catalysis, computational chemistry, molecular modeling, analytical chemistry, anesthesiology, medicinal chemistry, regenerative medicine, drug delivery, biostatistics, cardiac physiology

Courses

General Chemistry I

Inorganic Chemistry

Current Topics in Inorganic Research

Inorganic Chemistry II

Honors Fundamentals of Chemistry

Advanced Inorganic Chemistry

Recent Grants

	2018	$999.6K	Active
Supporting Success of Science Transfer Students
	2009	$226.8K
REU Site: Collaborative Research in the Chemical Sciences at the University Of Arizona
	2009	$54.2K
HNO-Donating Prodrugs for Use as Pharmaceuticals and Biomedical Research Tools
	2009	$15.0K
Arizona Partners in Science Award
	2007	$585.0K
CAREER: Mechanistic Analysis of Nitrogen Oxide Chemistry Under Biologically Relevant Conditions
	2006	$1.1M
Assessment of the Chemical Biology of HNO via New Donors

Technologies / Patents

	2019	Compositions And Methods Of Diazeniumdiolate-Based Prodrugs For Treating Cancer
	2014	Nitroxyl (HNO) Releasing Compounds and Uses Thereof in Treating Diseases
	1899	Nitroxyl (HNO) Releasing Compounds and Uses Thereof in Treating Diseases
	1899	Compositions and Methods of Diazeniumdiolate-Based Prodrugs for Treating Cancer

News

2013	Google Awards Grant for UA-Developed Online Chemistry Course
2013	Three UA Professors Elected as AAAS Fellows
2009	Chemistry Professor Honored in Washington, D.C.
2004	Eminent Scholar Series

Publications (80)

Recent

2022	HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation
2021	Nitric Oxide and Cancer: When to Give and When to Take Away?
2019	Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance
2016	Special issue in honour of Prof. Peter C. Ford
2015	Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast Cancer
2015	Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion
2014	Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway
2014	Persulfides and the cellular thiol landscape
2014	Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways
2014	Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates
2014	Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film
2013	The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats
2013	Biological nitric oxide signalling: Chemistry and terminology
2013	Mechanisms of nitric oxide reactions mediated by biologically relevant metal centers
2013	Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives
2013	Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent
2011	HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH
2011	The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems
2010	Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class
2010	The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O sub 2 /sub sup .- /sup is alive and well
2010	Reactions of HNO with heme proteins: New routes to HNO-heme complexes and insight into physiological effects
2009	Comparing the chemical biology of NO and HNO
2009	The emergence of nitroxyl (HNO) as a pharmacological agent
2009	The effects of nitroxyl (HNO) on soluble guanylate cyclase activity. Interactions at ferrous heme and cysteine thiols
2009	Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications
2008	The inducing NO-vasodilation by chemical reduction of coordinated nitrite ion in cis-[Ru(NO sub 2 /sub )L(bpy) sub 2 /sub ] sup + /sup complex
2008	Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine
2008	Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide
2008	Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses
2007	The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO sup 1 /sup 1This review is dedicated to the career of Prof. Herbert T. Nagasawa, a pioneer in the field of HNO chemistry, biochemistry and pharmacology.
2006	Discriminating formation of HNO from other reactive nitrogen oxide species
2006	Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations
2006	Peroxynitrite and myocardial contractility: In vivo versus in vitro effects
2006	The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling
2005	Donors of HNO
2005	Nitroxyl (HNO): Chemistry, biochemistry, and pharmacology
2005	The chemistry of nitroxyl (HNO) and implications in biology
2005	Comparison of the chemical biology of NO and HNO: An inorganic perspective
2004	The chemical dynamics of NO and reactive nitrogen oxides: A practical guide
2004	Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between sup • /sup NO and oxidative stress
2004	The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
2003	Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species
2003	Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: A novel redox paradigm
2003	Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning
2003	Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins: A chemical discussion of the differential biological effects of these redox related products of NOS
2003	Positive inotropic and lusitropic effects of HNO/NO sup - /sup in failing hearts: Independence from β-adrenergic signaling
2003	Heme proteins and nitric oxide (NO): The neglected, eloquent chemistry in NO redox signaling and regulation
2003	Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
2002	Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: Effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite
2002	Ingress and reactive chemistry of nitroxyl-derived species within human cells
2002	Comparison of the NO and HNO donating properties of diazeniumdiolates: Primary amine adducts release HNO in vivo
2002	Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins - A chemical discussion of the differential biological effects of these redox related products of NOS
2002	Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O sub 2 /sub sup - /sup reaction
2002	A chemical perspective on the interplay between NO, reactive oxygen species, and Reactive Nitrogen Oxide Species
2002	Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms
2002	Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH
2002	Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems
2001	The reduction potential of nitric oxide (NO) and its importance to NO biochemistry
2001	Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion
2001	Protein nitration is mediated by heme and free metals through Fenton-type chemistry: An alternative to the NO/O-2(-) reaction
2001	Nitroxyl anion regulation of the NMDA receptor
2001	Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling
2001	Distinction between Nitrosating Mechanisms within Human Cells and Aqueous Solution
2001	Cytotoxicity related to oxidative and nitrosative stress by nitric oxide
2001	The oxidative and nitrosative chemistry of the nitric oxide superoxide reaction in the presence of bicarbonate
2001	Mechanisms of the antioxidant effects of nitric oxide
2001	Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: Insights into Listeriocidal activity of oxidative and nitrosative stress
2000	A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
2000	Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals
2000	A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity
2000	Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from beta-adrenergic signaling
2000	Inhibitory effects of nitric oxide and nitrosative stress on dopamine- β-hydroxylase
2000	Effects of oxidative and nitrosative stress in cytotoxicity
1999	Mechanisms of cell death governed by the balance between nitrosative and oxidative stress
1999	The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate
1998	Flash photolysis studies of the ruthenium(II) porphyrins RU(P)(NO)(ONO). Multiple pathways involving reactions of intermediates with nitric oxide
1998	Photochemistry of metal nitrosyl complexes. Delivery of nitric oxide to biological targets
1998	A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
1997	Synthesis and Structural Characterization of Several Ruthenium Porphyrin Nitrosyl Complexes
1997	Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide

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