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John Regan

Professor, Pharmacology and Toxicology | Member of the Graduate Faculty | Professor, Neuroscience - GIDP

Pharmacology and Toxicology
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Collaboration(5)

  • Xinxin Ding

  • Qin Chen

  • Mark Nelson

  • Sally Dickinson

  • John Bloom

Publications(147)

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Recent

Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells

2019
short-chain fatty acids, colon cancer, butyrate, prostanoid ep receptors, cyclooxygenase-2 induction

Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding regio

2018
cellular density, hif-1α, c-myc, ep4 receptor, sp-1-binding

Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line

2017
cancer, indole compounds, cellular growth inhibition, 15-hydroxyprostaglandin dehydrogenase, colon cancer

PGE and E show lower efficacies than E to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors

2017
prostanoid receptors, β-catenin, ligands, efficacies, pge

Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands

2016
prostanoid receptors, ligand binding, receptor conformation, human dp receptor, ep2 receptor

Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells

2015
cancer, cellular biology, hypoxia, prostaglandins, gene regulation

Prostaglandin E-2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E-2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells

2015
prostaglandin, receptor signaling, colon cancer, signal transduction

A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells

2014
cancer, drug development, prostaglandins, cell signaling, receptor antagonists

Induction of cyclooxygenase-2 expression by prostaglandin E sub 2 sub stimulation of the prostanoid EP4 receptor via coupling to G sub αi sub and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells

2013
cancer biology, cell signaling, molecular biology, inflammatory response, drug development

Prostanoid EP sub 1 sub receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB

2012
John Regan | KMap Profile - Institutional Knowledge Map (KMap)