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Courses
  • CB
    Cancer Basics

  • ATCB
    Advanced Topics in Cancer Biology

  • SC
    Scientific Communication

  • CD
    Cancer Discoveries

  • CDB
    Cell and Developmental Biology

  • TBC
    The Biology of Cancer

Grants
  • Funding agency logo
    Induction of Lysosomal Trafficking to Target Growth and Metastasis

    Principal Investigator (PI)

    2018

    $556.6K
  • Funding agency logo
    STTR: Combinatorial Inactivation of ERBB Receptors In Breast Cancer using Therapeutic Stapled Peptides

    Principal Investigator (PI)

    2016

    $149.1K
  • Funding agency logo
    Decoy Peptides: Development of a Novel Therapeutic for Metastatic Cancer

    Principal Investigator (PI)

    2013

    $100.5K
  • Funding agency logo
    Theranostic Development for the Treatment of Metastatic Breast Cancer

    Principal Investigator (PI)

    2012

    $112.1K
  • Funding agency logo
    Theranostic Development for the Treatment of Metastatic Breast Cancer

    Principal Investigator (PI)

    2011

    $112.5K
  • Funding agency logo
    The Role of HUGL-1 in Epithelial Cell Polarity and Breast Cancer

    Co-Investigator (COI)

    2011

    $98.9K
  • Funding agency logo
    MUC1 Expression Promotes erdb-B3 Dependent Signaling and Facilitates Cell Transformation

    Co-Investigator (COI)

    2011

    $91.7K
  • Funding agency logo
    Theranostic Development for the Treatment of Metastatic Breast Cancer

    Principal Investigator (PI)

    2010

    $112.5K
  • Funding agency logo
    Therapeutic Peptides for the Treatment of Metastatic Cancer

    Principal Investigator (PI)

    2010

    $42.7K
  • Funding agency logo
    Mechanisms Underlying Cell Polarity in Breast Tumors

    Co-Investigator (COI)

    2009

    $566.8K
Technologies / Patents
      News
      • UArizona Testing App to Alert Students, Employees Exposed to COVID-19

        2020

      • UArizona and Covid Watch Launch COVID-19 Exposure Notification App

        2020

      • New Molecular Research Discovery May Translate to New Treatments for Viral Diseases

        2016

      • UA Students Take Aim on Top Careers in STEM

        2015

      • Research Forum Acknowledges Undergraduate Scholarship

        2008

      • TRIF Funding at the UA: BIO5, Arizona Cancer Center Pursuing First-Class Cancer Therapies

        2007

      Publications (59)
      Recent
      • Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor

        2023

      • Application of Microfluidic Systems for Breast Cancer Research

        2022

      • Cxcl10 Chemokine Induces Migration of ING4-Deficient Breast Cancer Cells via a Novel Cross Talk Mechanism between the Cxcr3 and Egfr Receptors

        2022

      • Wrong place at the wrong time: how retrograde trafficking drives cancer metastasis through receptor mislocalization

        2019

      • Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

        2019

      • Wrong Place at the Wrong Time: How Retrograde Trafficking of Receptor Tyrosine Kinases Drives Cancer Metastasis

        2018

      • MiR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila

        2018

      • mediates the role of Lethal giant larvae as an epithelial growth inhibitor in

        2018

      • Clinicopathological and Molecular Characteristics of Pleomorphic Invasive Lobular Carcinoma

        2017

      • Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration

        2017

      • em miR-9a /em mediates the role of Lethal giant larvae as an epithelial growth inhibitor in em Drosophila /em

        2017

      • Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication

        2016

      • Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration

        2016

      • Isolation of viable cancer cells in antibody-functionalized microfluidic devices

        2014

      • Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression

        2013

      • MUC1 and metastatic cancer: Expression, function and therapeutic targeting

        2013

      • MUC1 drives c-Met-dependent migration and scattering

        2012

      • MUC1 Drives c-Met ndash;Dependent Migration and Scattering

        2012

      • On the minimum detection limit of circulating tumor cells in an antibody-functionalized microchannel array

        2012

      • Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation

        2012

      • Flow-rate dependent capture of circulating tumor cells in bio-functional microchannels

        2012

      • Understanding the dual nature of CD44 in breast cancer progression

        2011

      • Adhesion dynamics of circulating tumor cells under shear flow in a bio-functionalized microchannel

        2011

      • Cell receptor and surface ligand density effects on dynamic states of adhering circulating tumor cells

        2011

      • A high-performance microsystem for isolating circulating tumor cells

        2011

      • Dynamic states of adhering cancer cells under shear flow in an antibody-functionalized microchannel

        2011

      • CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression

        2011

      • Kinematics of specifically captured circulating tumor cells in bio-functionalized microchannels

        2010

      • MUC1 regulates nuclear localization and function of the epidermal growth factor receptor

        2010

      • Quantitative specific binding of breast cancer cells in an antibody-functionalized microchamber array

        2010

      • Specific binding of cancer cells using a microchamber array functionalized with antibodies

        2010

      • Matrix hyaluronan alters epidermal growth factor receptor-dependent cell morphology

        2010

      • Anti-cancer therapies that utilize cell penetrating peptides

        2010

      • Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice

        2010

      • Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel

        2009

      • Flow acceleration effect on canser cell deformation abd detachment

        2009

      • Attachment & detachment of prostate cancer cells in a microfluidic system

        2008

      • Intracellular MUC1 Peptides Inhibit Cancer Progression

        2008

      • Go or Grow: How HA Controls the EGF Receptor

        2008

      • MUC1 is a novel regulator of ErbB1 receptor trafficking

        2007

      • Transforming growth factor α-dependent cancer progression is modulated by Muc1

        2007

      • Transforming growth factor alpha dependent cancer progression is modulated by Muc1

        2007

      • Transforming Growth Factor alpha; ndash;Dependent Cancer Progression Is Modulated by Muc1

        2007

      • CD44 Attenuates Metastatic Invasion during Breast Cancer Progression

        2005

      • MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

        2004

      • MUC1 can interact with adenomatous polyposis coli in breast cancer

        2004

      • Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling

        2003

      • MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion

        2003

      • Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors

        2002

      • ErbB-β-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas

        2002

      • Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland

        2001

      • Cooperative induction of mammary tumorigenesis by TGFα and Wnts

        2000

      • Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland

        1998

      • Transgenic mice reveal roles for TGFα and EGF receptor in mammary gland development and neoplasia

        1997

      • Characterization of the mouse transforming growth factor gene: Its expression during eyelid development and in waved 1 tissues

        1996

      • Inhibition of Mammary Gland Involution Is Associated with Transforming Growth Factor α but not c-myc-induced Tumorigenesis in Transgenic Mice

        1995

      • Recognition Molecules and Immunoglobulin Domains in Invertebrates

        1994

      • Evaluation of Drosophila melanogaster as an alternative animal for studying the neurotoxicity of heavy metals

        1992

      • Isolation of a putative protoimmunoglobulin in Pyura hausteria

        1991

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