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John Jewett

Member of the Graduate Faculty,

Associate Professor, Chemistry and Biochemistry-Sci,

Associate Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
jjewett@arizona.edu

520/626-3627

Grant: $972.4K

John Jewett experts in organic chemistry, organic synthesis, medicinal chemistry, molecular biology, organometallic chemistry, catalysis, biochemistry, pharmaceutics, drug delivery, bioinformatics, computational biology, protein structure prediction, mycobacterium tuberculosis, biophysics, chemical biology, virology, inorganic chemistry

Courses

Lectures in Organic Chemistry

Topics in Chemical Biology

Synthetic and Mechanistic Organic Chemistry

Mechanisms of Organic Reactions

Honors Lectures in Organic Chemistry

Recent Grants

	2022	$82.3K	Active
Research Collaboration Agreement
	2019	$150.0K	Active
James H. Gilliam, Jr. Fellowship for Advanced Study
	2016	$640.1K
CAREER: Triazabutadienes as a Versatile Tool in Chemical Biology
	2013	$100.0K
Fundamental understanding of the reaction to generate organic diazo compounds from azido-organic starting materials

Technologies / Patents

	2022	Triazabutadienes As Cleavable Cross-Linkers
	2021	Methods And Systems For Determining States Of Molecule Folding, Conformation, Or Interaction And Applications For Detecting Proteopathies
	2021	Substituted triazenes protected from degradation by carboxylation of N1
	2019	Substituted Triazenes Protected from Degradation by Carboxylation of N1
	2018	Water-Soluble Triazabutadienes
	2018	Triazabutadienes as Cleavable Cross-Linkers
	2017	Triazabutadienes as Cleavable Cross-Linkers
	1899	Water-Soluble Triazabutadienes
	1899	Reversibly Protected Triazabutadienes and Triazabutadiene-Derived Fluorophores
	1899	Triazabutadienes As Cleavable Cross-Linkers
	1899	Methods and Systems for Determining States of Molecule Folding, Conformation, Or Interaction
	1899	STABLE REACTIVE COMPOSITIONS FOR BIOCONJUGATION, PROBES, AND PROTEIN LABELING
	1899	Methods And Systems For Determining States Of Molecule Folding, Conformation, Or Interaction And Applications For Detecting Proteopathies

News

2019	UA Doctoral Student, Adviser Earn Prestigious Gilliam Fellowship
2016	Three UA Researchers Earn NSF CAREER Grants
2016	Program Preps UA Inventions for Market
2015	TLA Asset Demo Program Readies Inventions
2013	Chemistry Program Promotes Discovery-Based Experiences

Publications (29)

Recent

2022	Direct intracellular delivery of benzene diazonium ions as observed by increased tyrosine phosphorylation
2020	Discriminating changes in protein structure using tyrosine conjugation
2020	Highly stable Meldrum’s acid derivatives for irreversible aqueous covalent modification of amines
2020	Determining protein structure by tyrosine bioconjugation
2018	Coumarin triazabutadienes for fluorescent labeling of proteins
2017	Rapid in Situ Generation of Benzene Diazonium Ions under Basic Aqueous Conditions from Bench-Stable Triazabutadienes
2017	Synthesis of fluorescent heterocycles via a Knoevenagel/[4+1]-cycloaddition cascade using acetyl cyanide
2017	Hexyl triazabutadiene as a potent alkylating agent
2016	Light‐Activated Triazabutadienes for the Modification of a Viral Surface
2016	Cu-Click Compatible Triazabutadienes To Expand the Scope of Aryl Diazonium Ion Chemistry
2016	A gradient-free method for the purification of infective dengue virus for protein-level investigations
2016	Protecting Triazabutadienes To Afford Acid Resistance
2015	Water-soluble triazabutadienes that release diazonium species upon protonation under physiologically relevant conditions
2015	Water‐Soluble Triazabutadienes that Release Diazonium Species upon Protonation under Physiologically Relevant Conditions
2015	A Photobasic Functional Group
2013	A traceless staudinger reagent to deliver diazirines
2013	D-amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen
2012	Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry
2012	Reactivity of biarylazacyclooctynones in copper-free click chemistry
2011	Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry
2011	Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B
2010	Difluorobenzocyclooctyne: Synthesis, reactivity, and stabilization by β-cyclodextrin
2010	Cu-free click cycloaddition reactions in chemical biology
2010	Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones
2010	Temporary restraints to overcome steric obstacles: an efficient strategy for the synthesis of mycalamide B
2009	Preparation of (S)-4-Isopropyl-N-propanoyl-1,3-thiazolidine-2-thione
2007	Total synthesis of pederin
2003	Palladium-Catalyzed Asymmetric Phosphination. Enantioselective Synthesis of PAMP−BH3, Ligand Effects on Catalysis, and Direct Observation of the …
2003	Palladium-catalyzed asymmetric phosphination. Enantioselective synthesis of PAMP-BH sub 3 /sub , ligand effects on catalysis, and direct observation of the stereochemistry of transmetalation and reductive elimination

Grants

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Tech

Patents

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