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John Jewett

Member of the Graduate Faculty,
Associate Professor, Chemistry and Biochemistry-Sci,
Associate Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
jjewett@arizona.edu
520/626-3627
UAVitae logogoogle scholar logoOrcid logo
Grant: $972.4K
John Jewett experts in organic chemistry, organic synthesis, medicinal chemistry, molecular biology, organometallic chemistry, catalysis, biochemistry, pharmaceutics, drug delivery, bioinformatics, computational biology, protein structure prediction, mycobacterium tuberculosis, biophysics, chemical biology, virology, inorganic chemistry
Courses
Lectures in Organic Chemistry 
Topics in Chemical Biology 
Synthetic and Mechanistic Organic Chemistry 
Mechanisms of Organic Reactions 
Honors Lectures in Organic Chemistry 
Recent Grants
Logo of Research Collaboration Agreement funding agency
2022 $82.3KActive
Research Collaboration Agreement
Logo of James H. Gilliam, Jr. Fellowship for Advanced Study funding agency
2019 $150.0KActive
James H. Gilliam, Jr. Fellowship for Advanced Study
Logo of CAREER: Triazabutadienes as a Versatile Tool in Chemical Biology funding agency
2016 $640.1K
CAREER: Triazabutadienes as a Versatile Tool in Chemical Biology
Logo of Fundamental understanding of the reaction to generate organic diazo compounds from azido-organic starting materials funding agency
2013 $100.0K
Fundamental understanding of the reaction to generate organic diazo compounds from azido-organic starting materials
Technologies / Patents
Logo of Triazabutadienes As Cleavable Cross-Linkers
2022Triazabutadienes As Cleavable Cross-Linkers 
Logo of Methods And Systems For Determining States Of Molecule Folding, Conformation, Or Interaction And Applications For Detecting Proteopathies
2021Methods And Systems For Determining States Of Molecule Folding, Conformation, Or Interaction And Applications For Detecting Proteopathies 
Logo of Substituted triazenes protected from degradation by carboxylation of N1
2021Substituted triazenes protected from degradation by carboxylation of N1 
Logo of Substituted Triazenes Protected from Degradation by Carboxylation of N1
2019Substituted Triazenes Protected from Degradation by Carboxylation of N1 
Logo of Water-Soluble Triazabutadienes
2018Water-Soluble Triazabutadienes 
Logo of Triazabutadienes as Cleavable Cross-Linkers
2018Triazabutadienes as Cleavable Cross-Linkers 
Logo of Triazabutadienes as Cleavable Cross-Linkers
2017Triazabutadienes as Cleavable Cross-Linkers 
Logo of Water-Soluble Triazabutadienes
1899Water-Soluble Triazabutadienes 
Logo of Reversibly Protected Triazabutadienes and Triazabutadiene-Derived Fluorophores
1899Reversibly Protected Triazabutadienes and Triazabutadiene-Derived Fluorophores 
Logo of Triazabutadienes As Cleavable Cross-Linkers
1899Triazabutadienes As Cleavable Cross-Linkers 
Logo of Methods and Systems for Determining States of Molecule Folding, Conformation, Or Interaction
1899Methods and Systems for Determining States of Molecule Folding, Conformation, Or Interaction 
Logo of STABLE REACTIVE COMPOSITIONS FOR BIOCONJUGATION, PROBES, AND PROTEIN LABELING
1899STABLE REACTIVE COMPOSITIONS FOR BIOCONJUGATION, PROBES, AND PROTEIN LABELING 
Logo of Methods And Systems For Determining States Of Molecule Folding, Conformation, Or Interaction And Applications For Detecting Proteopathies
1899Methods And Systems For Determining States Of Molecule Folding, Conformation, Or Interaction And Applications For Detecting Proteopathies 
News
2019UA Doctoral Student, Adviser Earn Prestigious Gilliam Fellowship 
2016Three UA Researchers Earn NSF CAREER Grants  
2016Program Preps UA Inventions for Market 
2015TLA Asset Demo Program Readies Inventions  
2013Chemistry Program Promotes Discovery-Based Experiences 
Publications (29)
Recent
2022Direct intracellular delivery of benzene diazonium ions as observed by increased tyrosine phosphorylation 
2020Discriminating changes in protein structure using tyrosine conjugation 
2020Highly stable Meldrum’s acid derivatives for irreversible aqueous covalent modification of amines 
2020Determining protein structure by tyrosine bioconjugation 
2018Coumarin triazabutadienes for fluorescent labeling of proteins 
2017Rapid in Situ Generation of Benzene Diazonium Ions under Basic Aqueous Conditions from Bench-Stable Triazabutadienes 
2017Synthesis of fluorescent heterocycles via a Knoevenagel/[4+1]-cycloaddition cascade using acetyl cyanide 
2017Hexyl triazabutadiene as a potent alkylating agent 
2016Light‐Activated Triazabutadienes for the Modification of a Viral Surface 
2016Cu-Click Compatible Triazabutadienes To Expand the Scope of Aryl Diazonium Ion Chemistry 
2016A gradient-free method for the purification of infective dengue virus for protein-level investigations 
2016Protecting Triazabutadienes To Afford Acid Resistance 
2015Water-soluble triazabutadienes that release diazonium species upon protonation under physiologically relevant conditions 
2015Water‐Soluble Triazabutadienes that Release Diazonium Species upon Protonation under Physiologically Relevant Conditions 
2015A Photobasic Functional Group 
2013A traceless staudinger reagent to deliver diazirines 
2013D-amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen 
2012Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry 
2012Reactivity of biarylazacyclooctynones in copper-free click chemistry 
2011Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry 
2011Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B 
2010Difluorobenzocyclooctyne: Synthesis, reactivity, and stabilization by β-cyclodextrin 
2010Cu-free click cycloaddition reactions in chemical biology 
2010Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones 
2010Temporary restraints to overcome steric obstacles: an efficient strategy for the synthesis of mycalamide B 
2009Preparation of (S)-4-Isopropyl-N-propanoyl-1,3-thiazolidine-2-thione 
2007Total synthesis of pederin 
2003Palladium-Catalyzed Asymmetric Phosphination. Enantioselective Synthesis of PAMP−BH3, Ligand Effects on Catalysis, and Direct Observation of the … 
2003Palladium-catalyzed asymmetric phosphination. Enantioselective synthesis of PAMP-BH sub 3 /sub , ligand effects on catalysis, and direct observation of the stereochemistry of transmetalation and reductive elimination 
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