KMap
Courses
  • SMO
    Synthetic and Mechanistic Organic Chemistry

  • MOR
    Mechanisms of Organic Reactions

  • TCB
    Topics in Chemical Biology

  • LOC
    Lectures in Organic Chemistry

  • HLO
    Honors Lectures in Organic Chemistry

Student Thesis/Dissertation
  • Expanding the Chemical Probe Toolbox for Selective Bioconjugation and Targeted Delivery

    2023

    doctoral
  • Forging the Bioconjugate Toolbox: Development of Novel Probes for Orthogonal and Bioorthogonal Protein Functionalization

    2022

    doctoral
  • Base-Activated Lysine Probes and their Utility in Mosquito Larvae Midguts

    2022

    doctoral
  • SYNTHESIS OF NOVEL TRIAZINES, CHEMICAL PROPERTIES AND THEIR APPLICATIONS IN BIOCHEMISTRY

    2022

    bachelors
  • Protected Triazabutadienes in Chemical Biology

    2021

    doctoral
  • Synthetically Diverse Triazabutadienes and Their Applications Towards Biological Systems

    2021

    doctoral
  • The Development of Contrast Agents for PET/MRI and CatalyCEST MRI

    2019

    doctoral
  • Studies of the Reactivity of Selected Nitrogen-Rich Compounds

    2019

    doctoral
  • Design and Synthesis of Modular Reagents for Chemical Biology

    2018

    doctoral
  • Design and Synthesis of Triazabutadiene-based Fluorogenic Probes for Tyrosine Specific Labeling of Proteins

    2018

    doctoral
  • Detection of Enzyme Activity in a Pancreatic Tumor Model Using CatalyCEST Contrast MRI

    2017

    masters
  • Triazabutadienes and a Glycoprotein-Targeted Photocrosslinker as Protein-Labeling Agents

    2017

    doctoral
  • Using Bioorthogonal Chemistry for Investigating Dengue Virus Interactome

    2017

    bachelors
  • Development of Clickable Triazabutadienes as Cleavable Cross-Linkers

    2016

    masters
  • Triazabutadiene Chemistry in Organic Synthesis and Chemical Biology

    2016

    doctoral
  • Characterization of 4-demethylwyosine Synthase, a Radical S-adenosyl-l-methionine Enzyme Involved in the Modification of tRNA

    2016

    doctoral
  • A Bioorthogonal Approach to Chemical Virology

    2016

    doctoral
Grants
  • Funding agency logo
    Leveraging Releasable Aryl Diazonium Ions to Probe Biochemical Systems

    Principal Investigator (PI)

    2023

    $450.8K
    Active
  • Funding agency logo
    Research Collaboration Agreement

    Principal Investigator (PI)

    2022

    $82.3K
    Active
  • Funding agency logo
    James H. Gilliam, Jr. Fellowship for Advanced Study

    Principal Investigator (PI)

    2019

    $150.0K
  • Funding agency logo
    CAREER: Triazabutadienes as a Versatile Tool in Chemical Biology

    Principal Investigator (PI)

    2016

    $640.1K
  • Funding agency logo
    Fundamental understanding of the reaction to generate organic diazo compounds from azido-organic starting materials

    Principal Investigator (PI)

    2013

    $100.0K
Technologies / Patents
      News
      • UA Doctoral Student, Adviser Earn Prestigious Gilliam Fellowship

        2019

      • Three UA Researchers Earn NSF CAREER Grants

        2016

      • Program Preps UA Inventions for Market

        2016

      • TLA Asset Demo Program Readies Inventions

        2015

      • Chemistry Program Promotes Discovery-Based Experiences

        2013

      Publications (28)
      Recent
      • Direct intracellular delivery of benzene diazonium ions as observed by increased tyrosine phosphorylation

        2022

      • Highly stable Meldrum’s acid derivatives for irreversible aqueous covalent modification of amines

        2020

      • Discriminating changes in protein structure using tyrosine conjugation

        2020

      • Determining protein structure by tyrosine bioconjugation

        2020

      • Coumarin triazabutadienes for fluorescent labeling of proteins

        2018

      • Synthesis of fluorescent heterocycles via a Knoevenagel/4+1]cycloaddition cascade using acetyl cyanide

        2017

      • Rapid in Situ Generation of Benzene Diazonium Ions under Basic Aqueous Conditions from Bench-Stable Triazabutadienes

        2017

      • Hexyl triazabutadiene as a potent alkylating agent

        2017

      • A gradient-free method for the purification of infective dengue virus for protein-level investigations

        2016

      • Cu-Click Compatible Triazabutadienes To Expand the Scope of Aryl Diazonium Ion Chemistry

        2016

      • Light-Activated Triazabutadienes for the Modification of a Viral Surface

        2016

      • Protecting triazabutadienes to afford acid resistance

        2016

      • Water‐Soluble Triazabutadienes that Release Diazonium Species upon Protonation under Physiologically Relevant Conditions

        2015

      • A photobasic functional group

        2015

      • A traceless staudinger reagent to deliver diazirines

        2013

      • d-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen

        2013

      • Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry

        2012

      • Reactivity of biarylazacyclooctynones in copper-free click chemistry

        2012

      • Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry

        2011

      • Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B

        2011

      • Temporary restraints to overcome steric obstacles: An efficient strategy for the synthesis of mycalamideB

        2010

      • Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones

        2010

      • Cu-free click cycloaddition reactions in chemical biology

        2010

      • Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by β-cyclodextrin

        2010

      • Preparation of S)4-Isopropyl-N-propanoyl-1,3-thiazolidine-2-thione

        2009

      • Total synthesis of pederin

        2007

      • Palladium-catalyzed asymmetric phosphination. Enantioselective synthesis of PAMP-BH sub 3 sub ligand effects on catalysis, and direct observation of the stereochemistry of transmetalation and reductive elimination

        2003

      • Palladium-Catalyzed Asymmetric Phosphination. Enantioselective Synthesis of PAMP−BH3, Ligand Effects on Catalysis, and Direct Observation of the …

        2003

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