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Research Contributions and InnovationsThe main Research Interest in my research group has been the development of novel biomedical nanoparticle platforms for drug delivery, imaging and therapy. Main topics include;1.Nano/biomolecular polymeric structures with encapsulated anticancer drugs and gold shells for dual cancer therapy that combines controlled and targeted drug delivery and infrared thermal ablation. 2.Nano/biomolecular multifunctional para-magnetic metal-hybrid nanoparticles for diagnostics and target NIR therapy. We are now developing novel Nanoparticle Bioconjugates for Combination Therapy of Lung, Pancreatic and Breast cancer. We are also developing novel multifunctional magnetic nanoparticles for biodiagnostics and novel therapeutic applications.3.Development of novel specific adsorbents for low molecular weight biomarkers isolation and identification. Technology could be used not only for cancer biomarkers but potentially for any other disease that produces extraneous biomolecules.Show Less
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Courses
- EBPEngineering of Biological Processes
- CEMChemical Engineering Modeling
- TNEFTDDSTrends in Nanomedicine Engineering - Fundamentals of Therapeutics and Drug Delivery Systems
- ECEIIElements of Chemical Engineering II
- IPDDPIntroduction to Pharmacology, Drug Discovery & Pharmaceutics
- AEAAdvanced Engineering Analysis
- AMTTAdvanced Mass Transport Theory
- EEElectrochemical Engineering
- CREChemical Reaction Engineering
Grants
- A Molecular and Nanostructural Approach to Development of Ultrablack Coatings and Materials
Co-Investigator (COI)
2021
$200.0K
- Exploration of Methods of Observing Legionella in Water
Principal Investigator (PI)
2017
$20.0K
- Novel Polymer Adsorbents for Selective Peptide and Small Protein Separations from Blood
Principal Investigator (PI)
2016
$317.7K
- Nanotechnology 2020
Co-Investigator (COI)
2014
$576.8K
- Innovative Microsystems: Novel; Nanostructures to Capture Circulating Breast Cancer Cells
Co-Investigator (COI)
2007
$438.8K
News
- BIO5 Institute Funds Eight Collaborative Pilot Grants
2012
- UA Engineers Win Patent for Protein-Based Electronic Circuits
2011
- Faculty Senate Announces Election Results
2006
- Biology and Electronics May Soon Meet Inside Your MP3 player
2006
- Local Students Spend Their Summer in UA Labs
2005
- Faculty General Election Results
2003
- Research Group Will Use Proteins to 'Grow' Microchip Circuits
2003
- Office of Faculty Governance Posts Primary Election Results
2003
Publications (58)
Recent
- Mathematical modeling and parametrical analysis of the temperature dependency of control drug release from biodegradable nanoparticles
2019
- Biosynthesis of gold and silver nanoparticles using Parkinsonia florida leaf extract and antimicrobial activity of silver nanoparticles
2019
- Substrate-source flexibility of an exponential-fed perfusion process to produce plasmid DNA for use as leishmaniasis vaccine
2019
- Differential Response of BEAS-2B and H-441 Cells to Methylene Blue Photoactivation
2019
- Hollow Gold Nanoshells Encapsulated in PNIPAM Nanoparticles
2018
- Mathematical modeling of the batch adsorption of proteins on new restricted access media with poly(ethylene glycol) as a semi-permeable barrier using compact finite differences
2018
- Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles
2018
- Plasmid-DNA lipid nanovaccines: An innovative approach for a better world health
2018
- Enhancement of pDNA Uptake and Expression in H441 Cells by Using PLGA Nanocarriers.
2018
- Aqueous-Organic Phase Transfer of Gold and Silver Nanoparticles Using Thiol-Modified Oleic Acid
2017
- Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles.
2017
- Performance analysis of exponential-fed perfusion cultures for pDNA vaccines production
2017
- “Hollow Au–Ag bimetallic nanoparticles with high photothermal stability.”
2017
- Folate Functionalized PLGA Nanoparticles Loaded with Plasmid pVAX1-NH36: Mathematical Analysis of Release
2016
- Nanoparticle encapsulation and controlled release of a hydrophobickinase inhibitor: Three stage mathematical modelingand parametric analysis
2015
- Batch Equilibrium and Kinetic Studies of Plasmid pCI Adsorption onto Perfusion Particles
2015
- Purification of Human Serum Immunoglobulins Using Immobilized Metal Affinity Chromatography with Ethylenediamine Triacetic Acid as Chelating Agent
2015
- K88 Fimbrial Adhesin Targeting of Microspheres Containing Gentamicin Made with Albumin Glycated with Lactose
2015
- Adsorption of peptides and small proteins with control access polymer permeation to affinity binding sites. Part II: Polymer permeation-ion exchange separation adsorbents with polyethylene glycol and strong anion exchange groups
2012
- Formulation and characterization of gentamicin-loaded albumin microspheres as a potential drug carrier for the treatment of E. coli K88 infections
2012
- Adsorption of peptides and small proteins with control access polymer permeation to affinity binding sites. Part I: Polymer permeation-immobilized metal ion affinity chromatography separation adsorbents with polyethylene glycol and immobilized metal ions
2012
- Covalent coupling of polyacrylic acid coated magnetic-nanoparticles to multi-wall carbon nanotubes for manipulation targets
2011
- Modelling and simulation of plasmid DNA adsorption on ion-exchange membrane columns
2011
- Flow acceleration effect on canser cell deformation abd detachment
2009
- Purification of plasmid DNA using tangential flow filtration and tandem anion-exchange membrane chromatography
2009
- Breakthrough performance of plasmid DNA on ion-exchange membrane columns
2007
- Breakthrough performance of large proteins on ion-exchange membrane columns
2007
- Cyclododecane and cyclotridecane complexes with cobalt as potent histidine chelators: A theoretical study
2007
- Iminodiacetate as a chelating agent for histidine: A theoretical study
2006
- Selectivity of the chelator-protein interactions: A high level quantum chemistry study
2006
- Isolation of human serum immunoglobulins with a new salt-promoted adsorbent
2006
- Nucleation and growth of microtubules from γ-tubulin-functionalized gold surfaces
2006
- Novel hydrophobic interaction chromatography matrix for specific isolation and simple elution of immunoglobulins (A, G, and M) from porcine serum
2006
- Breakthrough performance of linear-DNA on ion-exchange membrane columns
2006
- Multilevel quantum chemistry approach to the development of a database of the SAM-ligand-metal ion-protein interactions
2005
- Analysis and simulation of frontal affinity chromatography of proteins
2005
- Breakthrough performance of stacks of dye-cellulosic fabric in affinity chromatography of lysozyme
2003
- Simulation of stirred tank affinity processes applied to separation of proteins
2001
- Mathematical analysis of frontal affinity chromatography in particle and membrane configurations
2001
- Hazardous waste and the US-Mexico border region: Toward a Binational, University-Based Institution
2000
- Optimal design of affinity membrane chromatographic columns
1999
- Production of 'neometalloenzymes' by de novo biosynthesis: New ELISA method for their characterization
1998
- Biosorption of Cu by Thiobacillus ferrooxidans
1998
- Dye affinity adsorbent replacement optimization
1998
- Design of affinity membrane chromatographic columns
1998
- Isolation of copper biochelates from Methylosinus trichosporium OB3b and soluble methane monooxygenase mutants
1998
- A new method of synthesizing biopolymeric affinity ligands
1997
- Adsorptive size exclusion chromatography (concentration), AdSEC
1997
- Synthesis of monoprotected derivatives of homo-bifunctional molecules
1997
- Modeling column regeneration effects on ion-exchange chromatography
1997
- Introduction to bioseparations: Affinity adsorption
1997
- Modeling column regeneration effects on dye-ligand affinity chromatography
1997
- Modelling regeneration effects on protein A affinity chromatography
1997
- Interactions and Applications of Soluble Heterobifunctional Affinity Chelating Polymers in Immobilized Metal Affinity Chromatography
1996
- Affinity partitioning of metal ions in aqueous polyethylene glycol/salt two-phase systems with PEG-modified chelators
1996
- Water-soluble nonionic surfactants for affinity bioseparations
1989
- Affinity surfactants as reversibly bound ligands for high-performance affinity chromatography
1988
- The adsorption of proteins to gas-liquid interfaces
1986