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Dr. Gayatri Vedantam is a Faculty member in the School of Animal & Comparative Biomedical Sciences at the University of Arizona (UA), and a US Dept. of Veterans Affairs Research Career Scientist. A molecular microbiologist by training, Dr. Vedantam has federally-funded research at UA and VA locations, and her laboratories focus on healthcare-associated infections. A long-term goal of these efforts is to develop safe and cost-effective non-antibiotic interventions to prevent and treat intestinal infections; one product (jointly protected via a collaborative VA and UA patent process) is currently completing pre-clinical studies. Dr. Vedantam is also deeply committed to teaching and outreach efforts, teaches both Undergraduate and Graduate-level courses, and is a UA STEM as well as Minority Student programs mentor. Dr. Vedantam holds Editorial Board appointments at multiple international science journals; these have fostered her current service interests which include faculty governance and ethics issues (and their resolution) emanating from 21st century realities such as the “publish-or-perish” academic model. She is past President of the American Society for Microbiology Southwestern Regional Chapter.Show Less
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Courses
- CCMMCore Concepts in Molecular Microbiology
- PBPathogenic Bacteriology
- EIDEcology of Infectious Disease
Grants
- Novel Treatment for Bacterial Pathogen C. Difficile
Principal Investigator (PI)
2023
$100.0K
Active - A Bio-controlled, Microbiota-Sparing, Live Biotherapeutic Anti-Infective for Clostridioides difficile
Principal Investigator (PI)
2022
$408.7K
Active - Host-cell Mitochondrial Alterations Play a Central Role in EPEC Pathogenesis
Co-Investigator (COI)
2019
$1.5M
Active - REU Site: Microbial Symbioses and Diversity Research Experience at the University of Arizona
Principal Investigator (PI)
2019
$478.3K
Active - A Microbiota-Sparing Live Biotherapeutic for C. Difficile Infection
Principal Investigator (PI)
2021
$100.0K
- IPA for Ms. Buss: Gastrointestinal Colonization of Diarrheagenic Clostridium Difficile
Principal Investigator (PI)
2020
$44.9K
- IPA for Mr. Lindsey: Gastrointestinal Colonization of Diarrheagenic Clostridium Difficile
Principal Investigator (PI)
2019
$103.0K
- Gastrointestinal Colonization of Diarrheagenic Clostridium Difficile
Principal Investigator (PI)
2018
$91.4K
- Perform Comparative Proteomics Analyses of Recent Clostridium Difficile and E. Coli Strains in the Presence of PanTheryx Hyperimmune Colostrum (IgG) and lgY Antibacterial Formulations
Principal Investigator (PI)
2018
$29.9K
- A Safe, Targeted, Designer Probiotic to Prevent or Treat C. Difficile Infection
Principal Investigator (PI)
2017
$1.1M
Technologies / Patents
News
- UArizona Research Labs Produce Hand Sanitizer for Area Health Care Workers
2020
Publications (48)
Recent
- Heterogeneity in stone culture protocols and endourologist practice patterns: a multi-institutional survey
2022
- The Alternative Sigma Factor SigL Influences Toxin Production, Sporulation, and Cell Surface Properties
2022
- Surface-displayed glycopolymers of Clostridioides difficile
2022
- Enteropathogenic em Escherichia coli /em regulates host-cell mitochondrial morphology
2022
- Low-toxin RT027 strains exhibit robust virulence
2022
- Stone culture practice patterns amongst fellowship-trained endourologists - a multi-institutional study
2022
- A Transmembrane GXXXG Motif Promotes EspZ Self-Association and Contributes to the Virulence of Attaching and Effacing Pathogens.
2020
- Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes
2020
- Anti-virulence strategies for infection: advances and roadblocks
2020
- Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Colitis while Dysregulating the Inflammatory Response
2019
- Epithelial maturity influences EPEC-induced desmosomal alterations
2018
- RhoGTPase Inhibition Contributes to Enteropathogenic Escherichia coli EspH-Induced Desmosomal Perturbations
2018
- An Engineered Synthetic Biologic Protects Against Infection
2018
- Characterisation of Clostridium difficile strains isolated from Groote Schuur Hospital, Cape Town, South Africa
2016
- A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence
2016
- The secreted effector protein EspZ is essential for virulence of rabbit enteropathogenic Escherichia coli
2015
- The Clostridium difficile protease Cwp84 modulates both biofilm formation and cell-surface properties
2015
- Enteropathogenic Escherichia coli dynamically regulates EGFR signaling in intestinal epithelial cells
2014
- Surface-Layer Protein A (SlpA) is a major contributor to host-cell adherence of clostridium difficile
2013
- Carbohydrate-based Clostridium difficile vaccines
2013
- Clostridium difficile carbohydrates: Glucan in spores, PSII common antigen in cells, immunogenicity of PSII in swine and synthesis of a dual C. difficile-ETEC conjugate vaccine
2012
- Leptin signaling protects the gut from Entamoeba histolytica infection.
2012
- Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization
2012
- Naming names: eponyms and biological history.
2012
- Clostridium difficile infection: Toxins and non-toxin virulence factors, and their contributions to disease establishment and host response
2012
- Spirochaetes and their twisted ways
2012
- The enteropathogenic Escherichia coli-secreted protein EspZ inhibits host cell apoptosis
2012
- Clostridium difficile clinical isolates exhibit variable susceptibility and proteome alterations upon exposure to mammalian cationic antimicrobial peptides
2012
- A more perfect union
2011
- Unlocking the gates to inflammatory bowel disease: The role of enterococcus faecalis gelatinase
2011
- Wrestling with recurrent infections
2011
- Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production
2010
- Identification of novel pathogenicity loci in Clostridium perfringens strains that cause Avian necrotic enteritis
2010
- Clostridium perfringens alpha toxin is produced in the intestines of broiler chicks inoculated with an alpha toxin mutant
2010
- Spore-forming Bacilli and Clostridia in human disease
2010
- Antimicrobial resistance in Bacteroides spp.: Occurrence and dissemination
2009
- Toxin B is essential for virulence of Clostridium difficile
2009
- Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile
2008
- Deciphering evolutionary mechanisms between mutualistic and pathogenic symbioses
2008
- Characterization of BctA, a mating apparatus protein required for transfer of the Bacteroides fragilis conjugal element BTF-37
2007
- Bacteroides fragilis mobilizable transposon Tn5520 requires a 71 base pair origin of transfer sequence and a single mobilization protein for relaxosome formation during conjugation
2006
- Antibiotics and anaerobes of gut origin
2003
- Isolation and characterization of BTF-37: Chromosomal DNA captured from Bacteroides fragilis that confers self-transferability and expresses a pilus-like structure in Bacteroides spp. and Escherichia coli
2002
- Antibiotic resistance among anaerobes: What does it mean?
2000
- Bacteroides fragilis transfer factor Tn5520: The smallest bacterial mobilizable transposon containing single integrase and mobilization genes that function in Escherichia coli
1999
- The bacteroides fragilis BtgA mobilization protein binds to the oriT region of pBFTM10
1998
- Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli
1998
- Characterization of a mutationally altered dihydropteroate synthase contributing to sulfathiazole resistance in Escherichia coli
1998