Courses
- SMOSynthetic and Mechanistic Organic Chemistry
- BBiochemistry
- MORMechanisms of Organic Reactions
- AOSAdvanced Organic Synthesis
- LOCLectures in Organic Chemistry
- OSAOrganic Structural Analysis Laboratory
Student Thesis/Dissertation
- Novel Materials Comprised of Molecular Springs: Synthetic Approaches to Bridgehead-Substituted Bicyclo[n.n.n]alkane Monomers
2023
doctoral - Development and Application of CEST MRI Contrast Agents that Evaluate Tumor Acidosis and Enzyme Activity
2020
doctoral - Crystal Engineering with Piperazinediones
2016
doctoral - Targeting Melanocortin and Cholecystokinin Receptors via Multivalent Molecules Bearing Peptide Ligands
2015
doctoral - Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
2014
doctoral
Grants
- (LTW) Novel Therapeutic Delivery System for Pediatric IBD
Co-Investigator (COI)
2022
$130.0KActive - The Development of a Solvent Free Process to Prepare DNAN
Principal Investigator (PI)
2017
$28.9K - UNS: Oligomers Derived from Emerging Nitroaromatic Pollutants in Anaerobic Environments: Mechanisms, Fate and Toxicity
Co-Investigator (COI)
2015
$330.0K - Development of New Liquid Crystalline Polyamides with Bicyclo[8.8.8] Hexacosane Flexible Segments
Principal Investigator (PI)
2015
$110.0K - Targeting Pancreatic Cancer
Co-Investigator (COI)
2009
$871.4K - Novel Inhibitors of AKT Signaling in Pancreatic Cancer
Co-Investigator (COI)
2009
$234.9K - Arizona Partners in Science Program
Principal Investigator (PI)
2009
$15.0K - Multimeric Ligands for Targeting Melanoma
Co-Investigator (COI)
2008
$1.3M - Southwest Environmental Health Sciences Center
Co-Investigator (COI)
2006
$7.8M - Redox-Sensitive & Blood-pool Contrast Agents for Magnetic Resonance Imaging
Co-Investigator (COI)
2006
$1.0M
Technologies / Patents
News
- 'Molecular Truck' Could Deliver New Treatment
2015
- UA Discovery Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
2014
- Couple's Gift Brings Nobel Laureate to UA
2008
Publications (118)
Recent
- Coupling reactions between reduced intermediates of insensitive munitions compound analog 4-nitroanisole
2019
- Solvent-free nitration of electron-rich arenes
2017
- Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors
2017
- Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model
2016
- Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor
2015
- Linear scaffolds for multivalent targeting of melanocortin receptors
2015
- Synthesis and bioactivity of MSH4 oligomers prepared by an A(2) B-2 strategy
2015
- pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase PTPN1)
2014
- Synthesis of 13C and 15N labeled 2,4-dinitroanisole
2014
- IMPROVED SYNTHESIS OF 10-2-ALKYLAMINO-2-OXOETHYL)1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID DERIVATIVES BEARING ACID-SENSITIVE LINKERS
2014
- Crystal Engineering with 1,4-Piperazine-2,5-diones
2014
- Spectrophotometric determination and removal of unchelated europium ions from solutions containing Eu-diethylenetriaminepentaacetic acid chelate-peptide conjugates
2014
- Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract
2013
- Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors
2013
- Substrate-dependent ligand inhibition of the human organic cation transporter OCT2
2013
- Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives
2012
- Heterobivalent ligands target cell-surface receptor combinations in vivo
2012
- Tumor xenograft response to redox-active therapies assessed by magnetic resonance imaging using a thiol-bearing DOTA complex of gadolinium
2012
- Design, synthesis, and testing of a molecular truck for colonic delivery of 5-aminosalicylic acid
2012
- Organic crystal engineering with 1,4-piperazine-2,5-diones. 8. Synthesis, crystal packing, and thermochemistry of piperazinediones derived from 2-amino-4,7-dialkoxyindan-2-carboxylic acids
2012
- On the synthesis of 1,4,7-tris(tert-butoxycarbonylmethyl)1,4,7,10- tetraazacyclododecane
2011
- Cell-specific targeting by heterobivalent ligands
2011
- Recent development of anticancer therapeutics targeting AKT
2011
- A sucrose-derived scaffold for multimerization of bioactive peptides
2011
- Development of sulfonamide AKT PH domain inhibitors
2011
- α-Tocopheryloxyacetic acid: A novel chemotherapeutic that stimulates the antitumor immune response
2011
- A solanesol-derived scaffold for multimerization of bioactive peptides
2010
- A synchrotron study of 2R,5′S)5′-benzyl-5-bromo-6-methoxy- spiro-indane-2,2′-piperazine]3′,6′-dione dimethyl-formamide solvate
2010
- Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7- triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging
2010
- Synthesis of the conformationally constrained tyrosine analogues, R) and S)5-hydroxy-2-aminoindan-2-carboxylic acids
2010
- Molecular pharmacology and antitumor activity of PHT-427, a novel akthosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor
2010
- Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors
2010
- Synthesis of conformationally constrained diaminodicarboxylic acid derivatives
2009
- In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT
2009
- Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain
2009
- Conformational analysis of bridgehead-substituted bicyclo[m.m.m]alkanes and bicyclo[8.8.n]alkanes
2009
- Organic crystal engineering with 1,4-piperazine-2,5-diones. 7. Crystal packing of piperazinediones derived from 2-amino-7-nitro-4-methoxyindan-2- carboxylic acid
2008
- (S,S)4′′-Cyano-7,7′′-dimeth-oxy-3′, 6′-dioxodispiro-indane-2,2′-piperazine-5′, 2′′-indane]4-carboxamide methanol solvate: Inter-rupting the amide-to-amide hydrogen-bonded tape
2008
- NOTE: Synthesis and characterization of a poly(acrylamide) with pendant 1,4-piperazine-2,5-dione moieties via post-polymerization cyclization
2008
- Discovery of a novel class of AKT pleckstrin homology domain inhibitors
2008
- Design, synthesis, and validation of a branched flexible linker for bioactive peptides
2007
- Squalene-derived flexible linkers for bioactive peptides
2007
- Deoxycholic acid induces intracellular signaling through membrane perturbations
2006
- Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin
2006
- Monomethylarsonous acid induces transformation of human bladder cells
2006
- Synthesis and fluorescence of N,N,N-trimethyl-2-methyl 7-nitrobenzo[c]l,2,5]oxadiazol-4-yl) amino]ethanaminium iodide, a pH-insensitive reporter of organic cation transport
2006
- Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture
2006
- Synthesis of 1,10-dimethylbicyclo[8.8.8]hexacosane and 1,10- dihydroxybicyclo[8.8.8]hexacosane
2005
- Synthesis of su14 suC]imexon
2005
- Organic crystal engineering with 1,4-piperazine-2,5-diones. 6. Studies of the hydrogen-bond association of cyclo[2-methylamino-4,7-dimethoxyindan-2- carboxylic acid)2-amino-4,7-dimethoxyindan-2-carboxylic acid)
2005
- Tris[2-2-oxidophenyl)5-phenyl-1,3,4-oxadiazole-κ su2 suO su2 su,N su3 su]aluminium 0.167-hydrate
2004
- An efficient synthesis of sodium dimethylarsinate- su14 suC
2003
- Organic crystal engineering with piperazine-2,5-diones. 4. Crystal packing of piperazinediones derived from 2-amino-7-cyano-4-methoxyindan-2-carboxylic acid
2003
- Crystal engineering of a liquid crystalline piperazinedione
2003
- Use of 9-methylfluorene as an indicator in the titration of common grouIA and grouIIA organometallic reagents
2002
- Synthesis and structure of the glutathione conjugate of chloroacetaldehyde
2002
- Monomethylarsonous acid MMA suIII su) and arsenite: LD sub 50 sub in hamsters and in vitro inhibition of pyruvate dehydrogenase
2001
- Stereochemical aspects of vinylcyclohexene bioactivation in rodent hepatic microsomes and purified human cytochrome P450 enzyme systems
2001
- Synthesis of S)β-cuparenone and S)cuparene
2000
- Synthesis of 7-alkoxyquinolines, coumarins, and resorufins
2000
- NBD-TMA: A novel fluorescent substrate of the peritubular organic cation transporter of renal proximal tubules
2000
- Intermolecular and intramolecular reactions of resolved 2-alkoxytetrahydrofuran-3-yl and 2-alkoxytetrahydropyran-3-yl radicals
2000
- The crystal packing of a strongly dipolar piperazinedione
2000
- 2,2'3,3'6,6'Hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11
1999
- Diastereoselective manipulations of bicyclo[m.1.0]alkane derivatives. 6. Stereocontrolled synthesis of tricyclo[m.n.0.0]alkenones
1999
- Organic crystal engineering with piperazine-2,5-diones. 1. Crystal packing of piperazinediones derived from substituted 2-aminoindan-2- carboxylic acids
1999
- Whispering-gallery-mode oscillation in a polymer microring laser
1998
- Near diffraction-limited laser emission from a polymer in a high finesse planar cavity
1998
- Synthesis of the mono-cysteine disulfide of meso-2,3-dimercaptosuccinic acid
1998
- Vertical-cavity surface-emitting polymer laser
1998
- Whispering-gallery-mode microring laser using a conjugated polymer
1998
- A cytochrome P450 terpenoid hydroxylase linked to the suppression of insect juvenile hormone synthesis
1998
- Diastereoselective manipulations of bicyclo[m.1.0]alkane derivatives. 5. α'Alkylations of bicycle[m.1.0]alkan-2-ones
1998
- Synthesis and characterization of highly efficient photorefractive polymer composites with long phase stability
1998
- On the reported intermediacy of vinyl radicals in spontaneous polymerization: An ESR-spin trapping study and its significance for the bond forming initiation theory
1997
- Development of Molecular Mechanics Torsion Parameters for α,β-Cyclopropyl α′,β′-Enones and Conformational Analysis of Bicyclo[m.1.0]alk-3-en-2-ones
1997
- Diastereoselective Manipulations of Bicyclo[m.1.0]alkane Derivatives. 4. Reactions of Nucleophiles with Bicyclo[m.1.0]alk-3-en-2-ones
1997
- Recent advances in photorefractive polymers and liquid crystals
1997
- Synthesis of ethyl N-diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates
1997
- Diastereoselective manipulations of bicyclo[m.1.0] alkane derivatives. 3. Nucleophilic additions to the carbonyl carbon of 1R,8R)Bicyclo[6.1.0]nonan-2,6-dione 2-2S,3S)1,4-Di-O-methyl-1,2,3,4-butane ketal
1997
- Improved syntheses of 2,2'3,3'6,6'hexachlorobiphenyl
1997
- Monobenzylation of 1,n-diols via dibutylstannylene intermediates
1997
- Diastereoselective manipulations of bicyclo[m.1.0]alkane derivatives. 2. Nucleophilic additions to the carbonyl carbons of bicyclot[m.1.0]alkan-2-ones
1996
- Syntheses and spectroscopic characterizations of oxidative metabolites of 4-vinylcyclohexene II diol-epoxides
1996
- Engineering molecular solids
1996
- Development of molecular mechanics torsion parameters for α,β-cyclopropyl ketones and conformational analysis of bicyclo[m.1.0]alkan-2-ones
1996
- Synthesis of the enantiomers of 4-vinylcyclohexene
1995
- Syntheses and spectroscopic characterizations of oxidative metabolites of 4-vinylcyclohexene
1994
- An efficient stereoconvergent synthesis of the 4-ethylamino-2,4-dideoxy-l-threo-pentopyranose component of the calicheamicins and esperamicins
1993
- Systematic search of transition state conformations
1992
- Acid-catalyzed dehydration for the design of chemical amplification resists
1992
- Structure of an enantiomerically pure tetrahydropyranyl ether
1991
- Negative chemical amplification resist systems based on polyhydroxystyrenes and N-substituted imides or aldehydes
1991
- Enantiomerically pure acetals in organic synthesis. 1. Chromatographic separability of furanoside and pyranoside acetals derived from α-hydroxy esters
1991
- Acid-catalyzed pinacol rearrangement. Chemically amplified reverse polarity change
1991
- Enantiomerically pure acetals in organic synthesis. 3. A synthesis of R)mevalonic acid lactone
1991
- Mechanistic studies of diastereoselective cyclopropanation via homochiral ketals. 2. Studies with conformationally restricted 2-cyclohexen-1-one ketals
1990
- Mechanistic studies of diastereoselective cyclopropanation via homochiral ketals. 1. Dioxolane structural effects
1990
- Diastereoselective manipulations of conformationally restricted enantiomerically pure bicyclo[m.1.0]alkanes. 1. Nucleophilic additions to the carbonyl carbons of bicyclo[m.1.0]alkan-2-ones
1990
- A new synthetic approach to the C-D ring portion of streptonigrin analogues
1990
- Selective inactivation of rat liver cytochromes P-450 by 21-chlorinated steroids
1989
- Homochiral ketals in organic synthesis. Enantioselective synthesis and absolute configuration of modhephene
1989
- Homochiral acetals in organic synthesis. A general enantioselective entry to carbohydrate derivatives from non-carbohydrate precursors
1989
- Homochiral ketals in organic synthesis. Diastereoselective cyclopropanation of α,β-unsaturated ketals derived from S,S)hydrobenzoin
1989
- Homochiral ketals in organic synthesis. Enantioselective preparation of modhephene
1988
- Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals
1988
- Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation
1988
- Homochiral ketals in organic synthesis. Enantioselective synthesis and absolute configuration of chokol A
1987
- Homochiral ketals in organic synthesis. Diastereoselective cyclopropanation of α,β-unsaturated ketals derived from 1,4-D1-O-benzyl-l-threitol
1987
- Diastereoselective cyclopropanation via homochiral ketals. Dioxolane structural effects
1987
- Homochiral ketals in organic synthesis. Enantioselective synthesis of β-eudesmol
1987
- Homochiral ketals in organic synthesis. Enantioselective synthesis of m.n.1] Propellanones
1986
- Homochiral ketals in organic synthesis. Diastereoselective cyclopropanation
1985
- Farnesylpyrophosphate synthetase. Evidence for a rigid geranyl cation-pyrophosphate anion pair
1981
- Farnesyl pyrophosphate synthetase. Mechanistic studies of the 1′-4 coupling reaction in the terpene biosynthetic pathway 13]
1979
- Farnesyl pyrophosphate synthetase. Mechanistic studies of the 1'4 coupling reaction with 2-fluorogeranyl pyrophosphate.
1978
- Prenyltransferase. New evidence for an ionization-condensation-elimination mechanism with 2-fluorogeranyl pyrophosphate 15]
1977
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