University of Arizona's High School Student NeuroResearch (NR) Program (HSNRP) nurtures trains and sustains thespirit of inquiry in a growing diverse connected workforce pipeline and faculty peer/near peer support network. Over thenext 5 years HSNRP will offer annually 10 talented motivated Arizonawide high school (8 weeks) and 3 progressingundergraduate students (10 weeks) full-time closely mentored hands on-brain on basic translational clinical and popula-tion research experiences emphasizing the workings and disorders of the normal and abnormal brain (favorite organ ofinterviewees) spinal cord and peripheral nervous system and encourage continuing involvement in more advancedresearch leading to science/medical/health-related careers. HSNRP leverages the strong infrastructure effective recruit-ment/retention strategies engaging student/faculty/near peer relationships and outstanding trainee productivity of ourlong-standing federally funded multidisciplinary disadvantaged high school/undergraduate/medical student summerresearch programs and year-round enrichment. Interacting together HSNRP trainees will be integrated into an innovativeinternationally recognized question-based Summer Institute on Medical Ignorance (SIMI) with novel mobile-accessiblesoftware platforms designed for collaboration and interweaving biomedical Knowns and Unknowns what we know wedon't know (research) don't know we don't know (discovery) and think we know but don't (error) i.e. unanswered/unasked questions and unquestioned answers. Bringing together multilevel trainees the summer curriculum featuresinformal triweekly general and NR biomedical topical seminars and faculty/SIMI alumni 'life stories' with periodicenrichment activities year-round emphasizing 'translating translation and scientific questioning' and introducing thelanguage and principles of pathobiology neuro-anatomy/physiology/pharmacology; clinical correlations laboratory/leadership/multimedia communication skill practice social networking and sustained career advising. Within multiplebasic and clinical departments and specialized Centers of Excellence and overseen by an energetic experienced multi-disciplinary HSNRP leadership team research encompasses cross-cutting themes and in vivo in vitro in situ in silicoand modeling approaches to neurobiology/disorders ranging from Parkinson and Alzheimer disease epilepsy traumaticbrain injury hydrocephalus muscular dystrophies headache pain/addiction to sleep disturbances brain tumors deepbrain stimulation molecular psychiatry cognition blood-brain barrier/neuroprotection neuroimaging neurogenomics/proteomics neuroengineering cerebral hemo/lymphovascular dynamics stroke and health disparities. Based on our~35-year track record and access to large diverse pools of disadvantaged/URM Arizona students reflected in 787 SIMI-trained high school students (including110 HSNRP alums) followed to date with substantial numbers in or workingtoward science and specifically NINDS mission-related basic science/clinical/teaching careers we expect HSNRP tocontinue to extend and enlarge the NR diversity pipeline and improve neurohealth literacy through community engage-ment. Ongoing evaluation includes feedback surveys database registry curiosity scales short-/long-term followup andindividual portfolios to document efficacy and the training model's sustainability and promote diversity and networking.