White Spot Disease (WSD), caused by the White Spot Syndrome Virus (WSSV) is a threat to crustacean farming (e.g., shrimp & crawfish) in the US and elsewhere in the world causing billions of dollars of losses, and there are no commercially available therapeutics against the disease, as of today. Our goal is to develop a therapeutic against WSD using an RNA interference (RNAi) approach. The objective is to develop a replication deficient viral vector to deliver RNAi molecules via oral route using commercial feed used in shrimp farming. We expect to develop an oral vaccine against WSD in shrimp and other crustaceans. Availability of an oral vaccine against WSD delivered by mixing it with a commercial diet, used in shrimp farming, can have an enormous impact in mitigating losses due to WSD, in the US and other shrimp producing countries in Asia and Latin America.