Environmental Health Sciences at the University of Arizona has a long-standing reputation forexcellence in training Ph.D. and postdoctoral scientists as evidenced by the fact that many of ourgraduates are leaders in academia industry and government. To this end our graduate programhas evolved from a systems-based toxicology experience to a curriculum in which students aretrained to apply state-of-the art techniques to solve mechanisms of environmental toxicityaffecting human diseases in various organ systems. The cutting-edge research programs of 30Training Grant Faculty members are augmented by innovative technologies developed at theUniversity of Arizona in association with the Southwest Environmental Health Sciences and BIO5Centers. Additionally translational approaches undertaken by our NIEHS Superfund Programand Dean Carter Binational Center for Environmental Sciences and Toxicology provide anexceptionally stimulating environment for the training of graduate students and postdoctoralfellows. The interactive research of our Training Grant Faculty and our state-of-the-art FacilityCores extend the training environment from a single laboratory-oriented domain to amultidisciplinary experience strongly supportive of collaborative research. Current trainees arenow selected through a University-wide competition and the UA Graduate College providesfinancial support for all first year Ph.D. students through an umbrella recruitment programproviding a large pool of highly qualified candidates for competitive selection of predoctoraltrainees. Predoctoral training is achieved through a combination of coursework laboratoryresearch and supplemental enrichment activities. Postdoctoral trainees participate in innovativeresearch programs and are guided to develop professional skills in oral and writtencommunication and leadership. Over the past five years our curricular changes have paralleledthe evolving expertise of the Training Grant Faculty. We have recruited eight senior fullProfessors three Associate Professors and seven junior Assistant Professors into the TrainingGrant which significantly enhanced our core strengths in mechanistic-based molecular toxicologytraining. The request for continuation of NIEHS support is justified by the highly successful natureof our program the clear demand for our graduates the strong emphasis we place on leadershipskills for our trainees and postdoctoral fellows the increasing number of students interested intoxicology and environmental health substantial institutional commitment the strong and well-funded research programs of our faculty and the excellence of the training environment.