Summers in Children's Research (SCR) at The University of Arizona Health Sciences Center Steele Children'sResearch Center and Diamond Children's Medical Center offers annually in this 5-year renewal grant proposal 12diverse disadvantaged junior/senior high school students and 5 continuing undergraduates from Arizona an immersiveeducational 8- and 12- week summer experience respectively in hands on brain on basic translational and clinicalresearch broadly targeting childhood and human development and associated disorders. The multidisciplinary projectleadership duo includes an internationally renowned pediatrician specialized in children's gastrointestinal disorders(molecular mechanisms and clinical management) and an international expert in childhood and developmental lymphaticdisorders and genotype-phenotype correlations diversity pipeline research training and inquiry curriculum innovation.They will together interact with vibrant research programs impacting children's and maternal health. Based on theCollege of Medicine's highly successful longstanding federally funded multidisciplinary disadvantaged multilevelstudent research programs and diversity/URM pipeline continuum drawing large numbers of qualified applicants fromaround Arizona and also a locally supported Dept. of Pediatrics high school student summer program SCR for the past 5years has been stepwise developing a distinctive core curriculum including online components and expanded researchexperiences in NICHD mission areas. Full-time summer research experiences range from molecular mechanisms ofcalcium/phosphate absorption in inflammatory bowel disease microbiomics and infant diarrheal disorders to genomics-proteomics of Niemann-Pick C disease and lymphedema-angiodysplasia syndromes; congenital heart disease mechanisms complications and management; autism disabilities and rehabilitation; next generation multimodalimaging; epidemiology of pediatric head trauma and substance abuse and field work in maternal health and sexuallytransmitted diseases. SCR involves experienced enthusiastic faculty and near-peer mentors primarily in Pediatrics butbroadly representing basic and clinical research impacting children in NICHD mission areas. The specialized SCRcurriculum is incorporated into an innovative face-to-face and online inquiry-based Summer Institute on MedicalIgnorance (highlighting Unanswered Questions and Unquestioned Answers and reinforcing core content) for high schoolstudents and undergraduates and paralleling our medical student researcher offering. Included are highly interactivefeatures such as our unique Virtual Clinical Research Center/Questionarium a web-based platform designed to link NIHCTSAs/GCRCs to the K-12 community using advanced multimedia technology familiar to teenagers. Peer and near-peermentoring and communication/surviving/thriving skill sessions are used to develop attitudes skills and behaviors offruitful curious and ethical scientists working in collaborative teams along career pathways in concert with theirrecruiting teachers. Extensive short-term/long-term formative and summative participant and project evaluationdocuments SCR's success to date and the progress of its diverse disadvantaged largely URM participants from resource-poor schools and will be continued to develop replicable models and products to disseminate nationally to other settings.