For more than two decades, the University of Arizona’s Petersen HIV Clinics (PHC) have increased access to specialized HIV medical care for people with HIV (PWH) in southern Arizona. PHC requests $275,248 per year for the 2022–2025 project period to provide quality HIV early intervention services (EIS) including medical care, medication, treatment adherence, and support services. PHC’s model of care is based on two nationally adopted guidelines: (1) the National Institutes of Health’s guidelines for clinical management of HIV disease and (2) the Primary Care Guidance for Persons with HIV developed by the HIV Medicine Association of the Infectious Disease Society of America. Service Area Needs: PHC resides in Pima County, the most populous county in southern Arizona. PHC’s service area covers six southern Arizona counties with more than 1.4 million people. HIV prevalence in the region is increasing, while incidence is either increasing or constant. In Pima County, new HIV cases nearly doubled between 2011 and 2018, increasing from 59 to 113. PHC is the only Ryan White funded clinic south of Phoenix that offers HIV specialty care by licensed infectious disease providers. PHC’s longstanding service to PWH communities has built rapport and trust which coupled with PHC’s capacity, can meet a growing demand for Ryan White Part C EIS. People Served: During the past 10 years, PHC’s patient population has grown rapidly, increasing from 416 patients served in 2011 to 998 patients in 2020. Target Populations: PHC serves men, women, and transgender adults with HIV, who are under- or uninsured, and who seek care in six southern Arizona counties. Patient recruitment focuses on low-income populations overrepresented among PWH, particularly Black Indigenous People of Color (BIPOC). BIPOC communities consistently experience disparate HIV rates and overrepresentation in emergent cases. Blacks make up 4.2% of Pima County’s population yet experience 13.9% of new infections. Hispanics make up 37.8% of Pima County’s population and 42.6% of new cases. Compared to the state, southern Arizona also sees higher incidence rates in men (~90% of all new infections), MSM (67.3% of new infections in urban areas), and young adults ages 20-34 in rural areas (51.5%). Proposed Services: PHC’s EIS program provides outpatient primary health care for PWH under or uninsured, including those lacking eligibility for public healthcare. If awarded, EIS funds will provide the following services: HIV post-test counseling, HIV medical care, specialty care, labs and diagnostic services, non-medical case management, treatment adherence, health education, and assistance with insurance benefit coordination. Funding will also support PHC’s clinical quality management efforts.