Club cells, also known as Clara cells, are a type of epithelial cell found in the respiratory tract, particularly in the lining of the bronchioles. These cells are named after their club-shaped appearance and play a key role in protecting the airways from harmful substances. Club cells secrete various proteins and enzymes that help to detoxify and protect the lungs from inhaled pollutants, allergens, and pathogens. They also assist in the maintenance of lung function and repair of damaged tissue. Studying club cells is important for understanding respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Researchers are exploring the functions and regulatory mechanisms of club cells to develop potential therapies for respiratory conditions.