Circulating biomarkers refer to molecules or substances that can be found in the blood or other bodily fluids and provide valuable information about a person's health or disease status. These biomarkers can include proteins, nucleic acids, hormones, enzymes, and other molecules that are released by cells or tissues into the bloodstream. Research in the field of circulating biomarkers aims to identify and validate specific biomarkers that can be used for early detection, diagnosis, prognosis, and monitoring of various diseases, such as cancer, cardiovascular disease, neurodegenerative disorders, and autoimmune conditions. By analyzing the levels of these biomarkers in blood samples, healthcare providers can gain insights into the underlying disease processes, assess treatment responses, and make more informed decisions about patient care. Advancements in technologies such as genomics, proteomics, and metabolomics have enabled researchers to discover new circulating biomarkers and develop sensitive and specific assays for their detection. This research area has the potential to revolutionize the field of precision medicine by enabling personalized and targeted therapies based on an individual's unique biomarker profile.