Calcification is the process by which calcium salts accumulate in an organic matrix, resulting in the hardening or stiffening of tissues. This process is essential for the formation and maintenance of bones and teeth in vertebrates. However, abnormal calcification can also occur in soft tissues, leading to diseases such as atherosclerosis, kidney stones, and osteoarthritis. Research in the field of calcification aims to better understand the mechanisms and regulation of this process, as well as its role in various diseases. This includes studying the molecular pathways involved in controlling calcification, identifying risk factors for abnormal calcification, and developing potential therapies to prevent or treat calcification-related diseases. Overall, research in this area has important clinical implications for a variety of medical conditions.