Profile

Ross Buchan

Member of the Graduate Faculty | Associate Professor, Molecular and Cellular Biology | Associate Professor, BIO5 Institute | Associate Professor, Cancer Biology - GIDP | Associate Professor, Neuroscience - GIDP

Molecular and Cellular Biology

Overview

Research

Collaboration(11)

Page 1 of 3

Grants(8)

Analysis of mRNP Granule Clearance, Vacuolar RNA Decay and TDP-43 Turnover
Active·2022·$1.1M·
External
Principal Investigator (PI)
rna regulation, neurodegeneration, cellular stress response, protein homeostasis, rna granules
Spatiotemporal Analysis of TDP-43 Toxicity and Endolysosomal Turnover Mechanisms
Active·2022·$393K·
External
Principal Investigator (PI)
neurodegeneration, cellular biology, protein aggregation, endolysosomal pathway, genetics
2022 Beckman Scholars Program
Active·2022·$78K / $156K·
External
Principal Investigator (PI)
undergraduate research, stem education, scholarship fund, biomedical research, mentorship
Regulation of P-Body Formation and mRNA Decapping in Cancer: Control by AKT and Pim Kinase Phosphorylation of EDC3
2020·$39.5K / $394.7K·
External
Co-Investigator (COI)
cancer, regulation, mrna, cell signaling, p-body formation
Endocytic Clearance of Cytoplasmic TDP-43: Mechanism and Role in ALS Pathology
2019·$104K·
External
Principal Investigator (PI)
endocytic pathways, tdp-43 aggregation, als pathology, cellular clearance mechanisms, protein homeostasis

Page 1 of 2

Publications(25)

Recent

HARLEY mitigates user bias and facilitates efficient quantification and co-localization analyses of foci in yeast fluorescence images

2022

image analysis, bias mitigation, quantification, co-localization, yeast

Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism

2022

protein regulation, neurodegeneration, endolysosomal pathway, protein toxicity, cellular clearance mechanisms

Guidelines for the use and interpretation of assays for monitoring autophagy 4th edition)1

2021

autophagy, assays, interpretation, guidelines, monitoring

EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics

2021

cell biology, molecular biology, cancer biology, cell signaling, regulatory mechanisms

RNAs as regulators of cellular matchmaking

2021

rna regulation, cellular interactions, gene expression, cell signaling, biological regulation

Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast

2020

signaling pathways, chemical perturbations, mrna decay rates, yeast, alterations

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation

2020

stress granule assembly, tdp-43 cytoplasmic aggregation, cellular stress response, protein aggregation, rna processing

RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly

2020

mrna regulation, protein interaction, p-body assembly, translational regulation, scaffold function

Cdc48/VCP and endocytosis regulate TDP-43 and FUS toxicity and turnover

2020

protein regulation, neurodegeneration, endocytosis, cellular toxicity, protein turnover

Stress Granules and ALS: A Case of Causation or Correlation?

2018

neurodegenerative diseases, rna biology, cellular stress response, medical research, genetics

People

Profile

Ross Buchan

Collaboration(11)

Anne Cress

Wei Wang

Chiu-Hsieh Hsu

Ritu Pandey

Fei Yin

Grants(8)

Analysis of mRNP Granule Clearance, Vacuolar RNA Decay and TDP-43 Turnover

Spatiotemporal Analysis of TDP-43 Toxicity and Endolysosomal Turnover Mechanisms

2022 Beckman Scholars Program

Regulation of P-Body Formation and mRNA Decapping in Cancer: Control by AKT and Pim Kinase Phosphorylation of EDC3

Endocytic Clearance of Cytoplasmic TDP-43: Mechanism and Role in ALS Pathology

Publications(25)

HARLEY mitigates user bias and facilitates efficient quantification and co-localization analyses of foci in yeast fluorescence images

Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism

Guidelines for the use and interpretation of assays for monitoring autophagy 4th edition)1

EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics

RNAs as regulators of cellular matchmaking

Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation

RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly

Cdc48/VCP and endocytosis regulate TDP-43 and FUS toxicity and turnover

Stress Granules and ALS: A Case of Causation or Correlation?