Photo of Indraneel Ghosh(ghosh)

Indraneel Ghosh

Member of the Graduate Faculty,
Professor, Chemistry and Biochemistry-Sci,
Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
520 621 6331
UAVitae logogoogle scholar logo
Grant: $4.4M
Biography Professor Neel Ghosh, is the Emily Davis and Homer Weed Distinguished Professor’08 at the University of Arizona. His laboratory is broadly interested in Chemical Biology and Protein Design and Engineering with a focus on developing new tools and methods for advancing human health. The laboratory has a particular current interest in understanding protein kinases and protein-protein interactions and designing new ways to inhibit them in human diseases. Neel Ghosh is also a co-founder and Chief Scientific Officer for Luceome Biotechnologies. Neel received his doctoral degree in 1998 while working with Professor Jean Chmielewski at Purdue University. His doctoral research focused on designing inhibitors of protein-protein interactions and self-replicating peptides. In 1998 he joined Professor Andrew Hamilton and Professor Lynne Regan’s laboratories at Yale University as a joint postdoctoral fellow. At Yale, he discovered the first conditional split-Green Fluorescent Protein, which has been used as a means for measuring protein-protein interactions by many laboratories and the methodology is sometimes called fluorescent protein complementation. In 2001, Neel Ghosh joined the Department of Chemistry and Biochemistry at the University of Arizona as an Assistant Professor and was promoted to Associate Professor and then to the Davis & Weed Chair and Full Professor in 2011.
Indraneel Ghosh experts in biochemistry, molecular biology, bioinformatics, computational biology, biophysics, structural biology, biosensors, medicinal chemistry, dna repair, machine learning, dna nanotechnology, neuroscience, pharmacology, drug delivery, peptide chemistry, peptides, microfluidics, biomaterials, systems biology, bioinorganic chemistry, self-assembly, i, supramolecular chemistry, neurodegenerative diseases, cell biology, genomics, chemical biology, rna biology, molecular diagnostics, molecular imaging, gpcrs, molecular dynamics, bioengineering, polymer chemistry, materials science, quantum dots, dna damage, nanomaterials, photovoltaics, dna sequencing, enzymology, pharmaceutics
Lectures in Organic Chemistry 
Honors Lectures in Organic Chemistry 
Explorations in Integrated Science 
Recent Grants
Logo of 2018 Beckman Scholars Program funding agency
2017 $156.0K
2018 Beckman Scholars Program
Logo of Orthogonally Gated Kinases and Phosphatases funding agency
2015 $1.2M
Orthogonally Gated Kinases and Phosphatases
Logo of A Toolbox for Gating Enzyme Activity Using Chemistry and Protein Design funding agency
2015 $480.0K
A Toolbox for Gating Enzyme Activity Using Chemistry and Protein Design
Logo of Kinase Selective Small Molecule Conjugates As Antibody Surrogates funding agency
2009 $357.1K
Kinase Selective Small Molecule Conjugates As Antibody Surrogates
Logo of Promoter Specific Hypermethylation Sensors for Early Cancer Detection funding agency
2009 $348.5K
Promoter Specific Hypermethylation Sensors for Early Cancer Detection
Logo of Structured Protein Scaffolds for Phage-Display funding agency
2006 $1.1M
Structured Protein Scaffolds for Phage-Display
Logo of SEER- A novel method for the detection of genetic sequences funding agency
2006 $684.6K
SEER- A novel method for the detection of genetic sequences
Technologies / Patents
Logo of Cell Free Methods for Detecting Protein-Ligand Binding
2012Cell Free Methods for Detecting Protein-Ligand Binding 
Logo of Cell Free Methods for Detecting Protein-Ligand Binding
1899Cell Free Methods for Detecting Protein-Ligand Binding 
Logo of Novel Split-Luciferase Enzymes and Applications Thereof
1899Novel Split-Luciferase Enzymes and Applications Thereof 
2014Two UA Students Named Beckman Scholars 
2011UA Offices, Programs Promote Undergraduate Research  
2011Six UA Students to Receive Medals for Leadership  
2010More than One Dozen UA Students Earn NSF Fellowships 
2009Professor Emeritus Recognized by American Chemical Society 
2009New Company Offers Hope of Faster Cancer Drug Development 
2009One Dozen Make the Pitch to Local Investors 
2009UA Student Scholar Presenting at National Symposium 
2008Research Forum Acknowledges Undergraduate Scholarship 
2007Entrepreneurship Students Move UA Technologies into Marketplace 
Publications (67)
2021Direct intracellular delivery of benzene diazonium ions as observed by increased tyrosine phosphorylation 
2015Mapping the BH3 Binding Interface of Bcl-X-L, Bcl-2, and Mcl-1 Using Split-Luciferase Reassembly 
2012New directions in targeting protein kinases: focusing upon true allosteric and bivalent inhibitors 
2011Selection of cyclic-peptide inhibitors targeting Aurora kinase A: Problems and solutions 
2011Small Molecule Gated Split-Tyrosine Phosphatases and Orthogonal Split-Tyrosine Kinases 
2011Testing the Promiscuity of Commercial Kinase Inhibitors Against the AGC Kinase Group Using a Split-luciferase Screen 
2011Tinkering outside the kinase ATP box: Allosteric (type IV) and bivalent (type V) inhibitors of protein kinases 
2011Split-protein systems: beyond binary protein-protein interactions. 
2010Direct DNA methylation profiling using methyl binding domain proteins 
2010High specificity in protein recognition by hydrogen-bond-surrogate α-helices: Selective inhibition of the p53/MDM2 complex 
2010Water-Based Route to Ligand-Selective Synthesis of ZnSe and Cd-Doped ZnSe Quantum Dots with Tunable Ultraviolet A to Blue Photoluminescence 
2010Turn-On DNA Damage Sensors for the Direct Detection of 8-Oxoguanine and Photoproducts in Native DNA 
2010PAF-AH catalytic subunits modulate the wnt pathway in developing gabaergic neurons 
2010High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate alpha-Helices: Selective Inhibition of the p53/MDM2 Complex 
2010A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases 
2010Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER) 
2009Phage Display Technology in Biosensor Development 
2009Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA 
2009Evaluating the Global CpG Methylation Status of Native DNA Utilizing a Bipartite Split-Luciferase Sensor 
2009Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling 
2008A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters 
2008A Fragment-Based Selection Approach for the Discovery of Peptide Macrocycles Targeting Protein Kinases 
2008Sequence-enabled reassembly (SEER) peptides for the detection of DNA sequences 
2007Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface. 
2007Molecules that target beta-amyloid 
2007Ligand-Gated Split-Kinases 
2007Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2 
2007Quantum dots and peptides: a bright future together 
2007Probing orientations of single fluorescent labels on a peptide reversibly binding to the human delta-opioid receptor 
2007The AviD-tag, a NeutrAvidin/avidin specific peptide affinity tag for the immobilization and purification of recombinant proteins 
2007Current trends in peptide science quantum dots and peptides: A bright future together 
2007Split β-lactamase sensor for the sequence-specific detection of DNA methylation 
2007When conjugated polymers meet amyloid fibrils 
2007Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules 
2007An Autoinhibited Coiled-Coil Design Strategy for Split-Protein Protease Sensors 
2007Tethering small molecules to a phage display library: Discovery of a selective bivalent inhibitor of protein kinase A 
2006A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death 
2006Inhibition of beta-amyloid fibrillization by directed evolution of a beta-sheet presenting miniature protein 
2006Sequence-enabled reassembly of β-lactamase (SEER-LAC): A sensitive method for the detection of double-stranded DNA 
2006Toward a General Approach for RNA-Templated Hierarchical Assembly of Split-Proteins 
2006Site-specific detection of DNA methylation utilizing mCpG-SEER 
2006Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics 
2006A General Approach for Receptor and Antibody-Targeted Detection of Native Proteins Utilizing Split-Luciferase Reassembly 
2006A minimalist approach toward protein recognition by epitope transfer from functionally evolved β-sheet surfaces 
2006When tight is too tight: Dasatinib and its lower affinity analogue for profiling kinase inhibitors in a three-hybrid split-luciferase system 
2006A Comprehensive Panel of Turn-On Caspase Biosensors for Investigating Caspase Specificity and Caspase Activation Pathways 
2006Highly selective cyclic peptide ligands for neutravidin and avidin identified by phage display 
2005Sequence-enabled reassembly of beta-lactamase (SEER-LAC): A sensitive method for the detection of double-stranded DNA 
2005Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: Scope and mechanism 
2005DNA sequence-enabled reassembly of the green fluorescent protein 
2004Peptide self-assembly as a model of proteins in the pre-genomic world 
2004DCX, a new mediator of the JNK pathway 
2004Single-site mutations in a hyperthermophilic variant of the B1 domain of protein G result in self-assembled oligomers 
2004Dual surface selection methodology for the identification of thrombin binding epitopes from hotspot biased phage-display libraries 
2004DCX's phosphorylation by not just another kinase (JNK) 
2004Helical supramolecules and fibers utilizing leucine zipper-displaying dendrimers 
2004Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides 
2001DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47 
2000Antiparallel leucine zipper-directed protein reassembly: Application to the green fluorescent protein [12] 
1999Inhibition of spontaneous receptor phosphorylation by residues in a putative α-helix in the KIT intracellular juxtamembrane region 
1999Structure-function relationship in a β-sheet peptide Inhibitor of E47 dimerization and DNA binding 
1998A self-replicating peptide under ionic control 
1998Selective amplification by auto- and cross-catalysis in a replicating peptide system 
1998A β-sheet peptide inhibitor of E47 dimerization and DNA binding 
1997A pH-modulated, self-replicating peptide 
1995Synthesis of the basic-helix-loop-helix region of the immunoglobulin enhancer binding protein E47 and evaluation of its structural and DNA binding properties 
1995Basic-helix-loop-helix region of tal: Evaluation of structure and DNA affinity