KMap
Our current research interests are the manner in which the processes involved in learning and memory consolidation depend on sleep and emotions; the neural substrates of PTSD; and the neural substrate of empathy. Our focus is on the role of substances called neuromodulators (e.g. acetylcholine, dopamine). We use a multi-disciplinary approach that includes in vitro and in vivo neurophysiology in rats, psychophysical tests in humans and computational models in computers. In collaboration with others, we also are interested in how knowledge about the brain can help in the building of better robots.

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Courses
  • CNAGMB
    Cognitive Neuroscience: A Guide to Mind and Brain

  • ICN
    Introduction to Computational Neuroscience

  • NEMCM
    Neural Encoding: Memory and Comprehension of Mammals

  • IB
    Introduction to Biopsychology

  • SN
    Systems Neuroscience

Grants
  • Funding agency logo
    RI: Medium: Collaborative Research: Experimental and Robotics Investigations of Multi-Scale Spatial Memory Consolidation in Complex Environments

    Principal Investigator (PI)

    2017

    $516.1K
    Active
  • Funding agency logo
    NIMH IPA Assignment Agreement

    Principal Investigator (PI)

    2019

    $175.8K
  • Funding agency logo
    Memory Consolidation During Sleep in Humans, Rodents and Computational Modelsans

    Principal Investigator (PI)

    2016

    $743.0K
  • Funding agency logo
    A Wireless Neural Recording System for the Study of Memory Consolidation in Naturalistic Environments

    Principal Investigator (PI)

    2015

    $131.0K
  • Funding agency logo
    CRCNS US-French Research Proposal: Collaborative Research: A Replay-Driven Model of Spatial Sequence Learning in the Hippocampus-PFC Network Using Reservoir Computing

    Principal Investigator (PI)

    2014

    $361.0K
  • Funding agency logo
    Memory Consolidation During Sleep in Humans, Rodents and Computational Models

    Principal Investigator (PI)

    2013

    $836.8K
  • Funding agency logo
    The Role of the Insular Cortex in the Expression of Empathy and Pro-social Behaviors in Rats.

    Key Personnel (KP)

    2013

    $95.0K
  • Funding agency logo
    CRCNS: Long Term Reactivations in Cortex and Hippocampus

    Principal Investigator (PI)

    2010

    $466.7K
  • Funding agency logo
    A Novel Paradigm to Investigate Memory Reconsolidation in Adults and Aged Rats

    Co-Investigator (COI)

    2009

    $83.9K
Technologies / Patents
      Books
      • A Biophysical Model of Cortical Up and Down States: Excitatory-Inhibitory Balance and H-Current

        2007

      • Who Needs Emotions?: The Brain Meets the Robot

        2005

      News
      • UA Researchers and Students to Educate the Public on Healthy Brain Activities

        2010

      • More than One Dozen UA Students Earn NSF Fellowships

        2010

      • Robots: One Day They’ll Walk Your Dog, Do Your Dishes and Tutor Your Kids

        2010

      • Neuroscience Researchers Seek Interns Ages 55 and Up

        2009

      Publications (101)
      Recent
      • Editorial: Advances in Computational Neuroscience

        2022

      • Biological Cybernetics: 60 years and more to come

        2021

      • Dorsal CA1 hippocampal place cells form a multi-scale representation of megaspace.

        2021

      • A Renewed Vision for Biological Cybernetics.

        2020

      • Transcranial magnetic stimulation reveals diminished homoeostatic metaplasticity in cognitively impaired adults

        2020

      • Conjunctive reward-place coding properties of dorsal distal CA1 hippocampus cells

        2020

      • A Computational Model for Latent Learning based on Hippocampal Replay

        2020

      • Ground truth construction and parameter tuning for the detection of sleep spindle timing in rodents

        2019

      • Explainable Artificial Intelligence for Neuroscience: Behavioral Neurostimulation

        2019

      • Welcome from the new Editor(s)-in-Chief

        2018

      • Dorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model

        2017

      • Beneficial effects of chronic oxytocin administration and social co-housing in a rodent model of post-traumatic stress disorder

        2016

      • Hippocampal CA1 Ripples as Inhibitory Transients

        2016

      • Contextual reminders fail to trigger memory reconsolidation in aged humans and rats

        2015

      • Reliability and precision are optimal for non-uniform distributions of presynaptic release probability

        2015

      • Offline reactivation of experience-dependent neuronal firing patterns in the rat ventral tegmental area

        2015

      • Influence of External Inputs and Asymmetry of Connections on Information-Geometric Measures Involving Up to Ten Neuronal Interactions

        2014

      • Value Learning and Arousal in the Extinction of Probabilistic Rewards: The Role of Dopamine in a Modified Temporal Difference Model

        2014

      • A connectionist model of context-based memory reconsolidation in the hippocampus: the role of sleep

        2014

      • Information-geometric measures estimate neural interactions during oscillatory brain states

        2014

      • The influence of multiple firing events on the formation and stability of activity patterns in continuous attractor networks.

        2013

      • Spatial scale and place field stability in a grid-to-place cell model of the dorsoventral axis of the hippocampus

        2013

      • A Computational Model of Perirhinal Cortex: Gating and Repair of Input to the Hippocampus

        2013

      • Involvement of the ventral tegmental area in a rodent model of post-traumatic stress disorder

        2013

      • Hippocampal anatomy supports the use of context in object recognition: A computational model

        2013

      • Spatial cognition: Robot target localization in open arenas based on rat studies

        2013

      • Amygdala Deep Brain Stimulation Is Superior to Paroxetine Treatment in a Rat Model of Posttraumatic Stress Disorder

        2013

      • Generalizing from human facial sexual dimorphism to sex-differentiate macaques: Accuracy and cultural variation

        2013

      • Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics

        2012

      • Multiple Spike Time Patterns Occur at Bifurcation Points of Membrane Potential Dynamics

        2012

      • Coding, stability, and non-spatial inputs in a modular grid-to-place cell model.

        2012

      • Remaking memories: reconsolidation updates positively motivated spatial memory in rats

        2012

      • Allothetic and idiothetic sensor fusion in rat-inspired robot localization

        2012

      • Adaptive recall in hippocampus

        2011

      • Finding the event structure of neuronal spike trains

        2011

      • Experience-dependent reactivations of ventral tegmental area neurons in the rat

        2011

      • A new similarity measure for spike trains: Sensitivity to bursts and periods of inhibition

        2011

      • Adaptive Recall in Hippocampus.

        2011

      • Computational models of reinforcement learning: The role of dopamine as a reward signal

        2010

      • Facial Resemblance to Emotions: Group Differences, Impression Effects, and Race Stereotypes

        2010

      • Analyzing spike train similarity measures: the effects of bursts and silence

        2010

      • Synchrony of Thalamocortical Inputs Maximizes Cortical Reliability

        2010

      • Emotion: Computational modeling

        2010

      • Erratum: Intrinsic subthreshold oscillations extend the influence of inhibitory synaptic inputs on cortical pyramidal neurons (European Journal of Neuroscience 31 (1019-1026))

        2010

      • Intrinsic subthreshold oscillations extend the influence of inhibitory synaptic inputs on cortical pyramidal neurons

        2010

      • Information-Geometric Measures as Robust Estimators of Connection Strengths and External Inputs

        2009

      • Information-geometric measures as robust estimators of connection strengths and external inputs.

        2009

      • Visual processing in the central bee brain

        2009

      • A biophysical model of cortical up and down states: Excitatory-inhibitory balance and H-current

        2008

      • Intrinsic current generated, omnidirectional phase precession and grid field scaling in toroidal attractor model of medial entorhinal path integration

        2008

      • Regulation of spike timing in visual cortical circuits

        2008

      • The processing of color, motion, and stimulus timing are anatomically segregated in the bumblebee brain

        2008

      • Emergence of reliable spike patterns in models of CA1 cells contacted by unreliable synapses

        2007

      • Supralinear reliability of cortical spiking from synchronous thalamic inputs.

        2007

      • Are Effects of Emotion Expression on Trait Impressions Mediated by Babyfaceness? Evidence From Connectionist Modeling

        2007

      • Models of emotion.

        2007

      • A Mechanistic View of the Expression and Experience of Emotion in the Arts

        2006

      • In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS

        2006

      • Selective attention through phase relationship of excitatory and inhibitory input synchrony in a model cortical neuron

        2006

      • Role of network dynamics in shaping spike timing reliability

        2005

      • Synchronization as a mechanism for attentional gain modulation

        2004

      • From human emotions to robot emotions

        2004

      • Discovering spike patterns in neuronal responses

        2004

      • Emotions: from brain to robot

        2004

      • Inhibitory synchrony as a mechanism for attentional gain modulation

        2004

      • Influence of Ionic Conductances on Spike Timing Reliability of Cortical Neurons for Suprathreshold Rhythmic Inputs

        2004

      • Trait impressions as overgeneralized responses to adaptively significant facial qualities: Evidence from connectionist modeling

        2003

      • A new correlation-based measure of spike timing reliability

        2003

      • Reliability and bifurcation in neurons driven by multiple sinusoids

        2003

      • Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity

        2003

      • Regulation of Persistent Activity by Background Inhibition in an In Vitro Model of a Cortical Microcircuit

        2003

      • Attractor reliability reveals deterministic structure in neuronal spike trains

        2002

      • Information transfer in entrained cortical neurons.

        2002

      • A Roles of Dopamine

        2002

      • Spike-time reliability of periodically driven integrate-and-fire neurons

        2002

      • Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons

        2001

      • Models of frequency preferences of prefrontal cortical neurons

        2001

      • Frequency dependence of spike timing reliability in cortical pyramidal cells and interneurons

        2001

      • The brain decade in debate: III. Neurobiology of emotion

        2001

      • Optimal information transfer in synchronized neocortical neurons

        2001

      • Computational model of carbachol-induced delta, theta, and gamma oscillations in the hippocampus

        2001

      • Dopamine modulation of prefrontal delay activity-reverberatory activity and sharpness of tuning curves

        2001

      • Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

        2001

      • Cholinergic induction of oscillations in the hippocampal slice in the slow (0.5-2 Hz), theta (5-12 Hz), and gamma (35-70 Hz) bands

        2000

      • Neuromodulatory basis of emotion

        1999

      • Computational Models of Neuromodulation

        1998

      • A role for NMDA-receptor channels in working memory

        1998

      • Emotion and computational neuroscience

        1998

      • Face Recognition by Elastic Bunch Graph Matching

        1997

      • Gender discrimination and prediction on the basis of facial metric information

        1997

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