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Courses
- IPTRIntroduction to Pharmacology and Toxicology Research
- MTCHMolecules That Changed History
- PIPharmacology I
- CSPCase Studies in Pharmacology
- CCSTCellular Communications and Signal Transduction
- IMTDDIntroduction to Molecular Therapeutics and Drug Discovery
- PDDDDPrinciples in Drug Discovery, Design, and Development
- MCIIMedicinal Chemistry II
- CSBPCase Studies in Biochemical Pharmacology
- BBPBiomolecular Basis of Pharmacotherapy
- PNADTProteins and Nucleic Acids as Drug Targets
- MBPMetabolic Basis of Pharmacotherapy
- MCMedicinal Chemistry
Grants
- NRF Transcription Factors in Environmental Stress and Disease Intervention
Co-Investigator (COI)
2020
$3.6M
Active - Redox and Protein Homeostasis in Arsenic Tumorigenicity
Principal Investigator (PI)
2020
$1.2M
Active - MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
Co-Investigator (COI)
2020
$342.9K
Active - Selective Modulation of Bacterial Chaperonins by Targeting Novel Small Molecule Binding Sites
Principal Investigator (PI)
2017
$470.7K
Active - Stress Response, p97, and Nrf2 in Arsenic-Mediated Toxicity
Principal Investigator (PI)
2014
$1.6M
News
- Scientists at the UA Make Critical End-Stage Liver Disease Discovery
2014
Publications (87)
Recent
- Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer
2021
- Sirtuin 2 Regulates Protein LactoylLys Modifications
2021
- Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL
2021
- Targeting NRF2 to treat cancer
2021
- The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis
2021
- Function, Therapeutic Potential, and Inhibition of Hsp70 Chaperones
2021
- FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells
2021
- Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
2021
- Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action
2021
- A two-step resin based approach to reveal survivin-selective fluorescent probes
2021
- The intricacies of NRF2 regulation in cancer
2021
- UniDecCD: Deconvolution of Charge Detection-Mass Spectrometry Data
2021
- Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors
2021
- NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
2020
- Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9
2020
- Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs
2020
- Survivin modulation in the antimelanoma activity of prodiginines
2020
- The role of natural products in revealing NRF2 function
2020
- Catalytic asymmetric synthesis of 2,5-dihydrofurans using synergistic bifunctional Ag catalysis
2019
- A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78
2019
- HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules
2019
- An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol
2019
- Correction: Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
2019
- Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism
2019
- Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation
2019
- Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections
2019
- Modulating NRF2 in Disease: Timing Is Everything
2019
- Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes
2019
- One-Step Synthesis of Thieno[2,3-]pyrimidin-4(3)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S and Formamide
2019
- A one-step, atom economical synthesis of thieno[2,3-]pyrimidin-4-amine derivatives via a four-component reaction
2019
- Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction
2018
- The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer
2018
- Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)
2018
- One-step synthesis of thieno[2,3-d]pyrimidin-4(3H)-ones via a catalytic four-component reaction of ketones, ethyl cyanoacetate, S8 and formamide
2018
- Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with Antitumor Activity
2018
- NRF2 and the Hallmarks of Cancer
2018
- eIF4A inhibition: ready for primetime?
2018
- A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)
2018
- Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus
2018
- Low-level arsenic causes proteotoxic stress and not oxidative stress
2018
- Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus
2017
- An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla
2017
- Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78
2017
- ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A
2017
- p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex
2017
- Arsenic Compromises Both p97 and Proteasome Functions
2017
- Brusatol overcomes chemoresistance through inhibition of protein translation
2017
- Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness
2016
- Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin
2016
- GroEL/ES inhibitors as potential antibiotics
2016
- Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii
2016
- Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding
2016
- NRF2-targeted therapeutics: New targets and modes of NRF2 regulation
2016
- Role of Nrf2 and Autophagy in Acute Lung Injury
2016
- The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway
2015
- Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system
2015
- A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
2015
- Inhibitors of the AAA+ chaperone p97
2015
- Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention
2015
- Functional chromatographic technique for natural product isolation
2015
- p62 links autophagy and Nrf2 signaling
2015
- Withaferin A Analogs That Target the AAA+ Chaperone p97
2015
- Oncogenic KRAS confers chemoresistance by upregulating NRF2
2014
- In situ natural product discovery via an artificial marine sponge
2014
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
2014
- Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action
2014
- A biochemical screen for GroEL/GroES inhibitors
2014
- USP15 negatively regulates Nrf2 through Deubiquitination of Keap1
2013
- Metabolic perturbation of an essential pathway: Evaluation of a glycine precursor of coenzyme A
2013
- Sulfotransferases and sulfatases: Sulfate modification of carbohydrates
2011
- Subcellular Protein Localization by Using a Genetically Encoded Fluorescent Amino Acid
2011
- Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid
2011
- The complexities of p97 function in health and disease
2011
- A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL
2009
- Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state
2008
- Two families of chaperonin: Physiology and mechanism
2007
- Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL
2006
- Sulfotransferases: Structure, mechanism, biological activity, inhibition, and synthetic utility
2004
- Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening
2004
- Synthesis of carbohydrate-based antibiotics
2003
- Mechanistic studies of β-arylsulfotransferase IV
2003
- A potent and highly selective sulfotransferase inhibitor
2002
- A pH sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: A case study using kinases
2002
- Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides
2000
- Mutational analysis of backbone hydrogen bonds in staphylococcal nuclease [2]
1997
- Linear free energy analysis of hydrogen bonding in proteins
1995
- Analysis of hydrogen bonding strengths in proteins using unnatural amino acids
1995