AbstractColon cancer is a leading cause of cancer death in the United States and worldwide. Colonoscopy is thepreferred screening method at an estimated annual cost of about $24 billion in the US. Unfortunately manylesions are missed because they can remain hidden from view behind folds and flexures of the colon. Currentmethods of increasing the field of view are ineffective and some are very expensive preventing the adoption ofthese methods into clinical practice.In this proposal we propose to develop a single viewpoint panoramic imaging technology which can provide360-degree side-view of the colon. The proposed panoramic imaging system consists of an array of imagingsystems which share the same viewpoint addressing the key barrier in reconstructing the panoramic image frommultiple imaging systems. We will develop a unique monolithic opto-mechanical design to integrate allsubsystems precisely without active alignment. The proposed single viewpoint panoramic imaging system canbe either integrated to the new colonoscope so that the colonoscope will have standard forward view and 360-degree panoramic side-view or built as a snap-on attachment for the current commercial colonoscopes toprovide 360-degree panoramic side-view.To demonstrate the imaging capability of the proposed single viewpoint panoramic system we will first developand characterize a single viewpoint panoramic attachment for the standard colonoscope and then evaluate theperformance in detecting polyps and compare to a standard colonoscope.The proposed single viewpoint panoramic imaging system will maximize the detection of polyps and substantiallyreduce the incidence of colon cancer. It will benefit the patients and society in five-fold: reducing incidence ofcolon cancer reducing the chance of interval cancer decreasing overall morbidity and mortality increasing theinterval between colonoscopies and reducing the economic burden of this disease.