Rising global temperatures increase the incidence of heat stress in production animal species, exacerbating global food insecurity, and costing billions of dollars annually. We have established that heat depresses milk production and mammary gland development similarly in rodents and ruminants. Heat causes a shift of blood flow away from the center of the body and toward the skin to allow for greater heat loss. We have shown that genetically or pharmacologically preventing this shift in blood flow prevents heat induced decreases in food intake and milk production. The studies proposed in this grant will focus on identifying pharmacological targets that can be used to increase food intake and milk production in heat stressed animals.Understanding the mechanism by which heat suppresses feed intake and milk production will allow for innovative technologies to improve production in hot environments.