This is the third renewal of Chemistry-Biology Interface (CBI) training grant T32 GM08804. Wehave designed an interdisciplinary program for training students (and faculty) at the interface ofbiological medicinal and traditional chemistry called the Biological Chemistry Program (BCP).The BCP began in the fall of 2000 and provides a focused cross-disciplinary education forstudents at the interface of biology and chemistry. The BCP is fully integrated into thedepartments of Chemistry and Biochemistry (Colleges of Science and Medicine) andPharmacology and Toxicology (Division of Drug Discovery and Development College ofPharmacy). Students may obtain a degree in Chemistry Biochemistry or PharmaceuticalSciences while following the Biological Chemistry Training Program. Students undertakegraduate coursework in Chemistry and Biology perform research rotations in at least tworesearch disciplines organize an annual retreat and participate in the weekly BCP ResearchForum where students and faculty present research results. Importantly students may work withanyone in the program regardless of departmental affiliation allowing for true multidisciplinaryresearch efforts. The training faculty includes 28 highly active research groups. Students remainin the BCP until graduation.There are 48 students currently following the training program 31 of whom are training granteligible. Of these 16% are from an underrepresented group. Training grant slots are generallyawarded for years 2 and 3 in the program allowing training grant recipients great flexibility inassembling a multidisciplinary research project. Fellowships are awarded in May to help first-year students assemble a broad-based mentoring team. For years 15-20 we request 6 traininggrant slots per year.Training at the Chemistry-Biology Interface is highly relevant for advances in public health. Byblending Chemistry Medicinal Chemistry and Biochemistry our trainees are poised to make thenext breakthroughs in drug discovery disease detection disease prevention and the discoveryof the underlying principles governing life and disease. Our 80 BCP graduates populate bothacademic science centers and disease-oriented private-sector companies.