The University of Arizona Banner Health (UA-Banner) All of Us Research Program (AoU RP) will utilize aparticipant-centered enrollment and retention strategy to accrue 20000 full participants annually during Year 1to 5 into the AoU RP cohort of one million or more full participants. Engagement and Enrollment: Ourapproach has undergone 12 months of planning and 6 months of extended beta phase testing during which wehave enrolled >2000 full participants aged 18 years into the AoU RP. We rely primarily on face-to-faceengagement of potential participants who are receiving care in the UA-Banner Health System. We aim tooperationalize 10 primary enrollment sites by the end of December 2017 which will then be increased to a totalof 13 enrollment sites by December 2018. An enrollment site is a healthcare facility or medical complex withinwhich the UA-Banner AoU RP has established one or moreenrollment units. An enrollment unit is a fully-equipped stationstaffed by an appropriate number of fully-trained and certifiedpersonnel who can implement the AoU RP protocol in its entirety.Daily enrollment targets from each of the enrollment sites aredepicted in Exhibit 1. We anticipate enrolling 102 full participantsper day for 196 of the 250 working days in a year (366 days -104weekend days 12 public holidays) to meet our enrollment targetof 20000 participants per year. We expect that the remaining 54working days serve as a buffer with a much lower averageenrollment of 30 participants per day (1620 per year). Theassumptions underlying these annual cumulative enrollmentcalculations are discussed in the section on Enrollment Targets.At full capacity we would have 65 clinical research coordinators(CRCs) 12 promotores and 20-24 physician champions acrossthe 10 enrollment sites (deployment is 60% complete as ofNovember 15 2017). Our enrollment campaign entails seveninitial engagement approaches by which Banner Heath patientsand other individuals can enter the pathway to becoming fullparticipants: (1) An AoU-RP introductory/invitation letter (approvedby the IRB) and signed by a physician provider is sent to patientswith an upcoming visit to see the physician provider at a healthcarefacility 3-4 weeks prior to the scheduled visit followed by atelephone contact and face-to-face enrollment encounter on day ofthe scheduled office visit; (2) Impromptu in-person introduction tothe AoU RP by our CRCs to patients their family members and/oraccompanying persons in the ambulatory care urgent care and in-patient settings; (3) IRB-approvedintroductory/invitation email to Banner Health Plan members and an algorithm-driven targeted pop-up AoU RPpromotional announcement on the My Banner portal accessible to all patients in the Banner Health systemwho have registered to use My Banner; (4) Tabling an engagement approach that utilizes a UA-BannerAoU RP emblazoned information table staffed by 1-2 CRCs that is temporarily stationed in a high traffic areawithin the healthcare facility where patients and other persons can receive information complete anExpression of Interest Card register or even be accompanied directly to our enrollment unit on-site to beginthe consenting processing followed by the baseline procedures; (5) Walk-ins enrollment of eligible individualsincluding employees of UA-Banner who have heard about the AoU RP and are willing to undergo anunscheduled AoU-RP enrollment/baseline visit; (6) Engagement visits initiated by 12 promotores who areliterally pounding the pavement in Hispanic/Latino neighborhoods to inform and identify potential participantsand schedule enrollment visits to the facility based enrollment sites; and (7) Organized AoU RP promotionalevents (ice cream socials Sonoran hot dog events health fairs enrollment site launch etc. ) which provide anopportunity to complete expression of interest cards schedule visits provide contact information or simply toobtain additional information about the AoU RP. Participant Engagement Boards (PEBs): C-suite to grassroots participant engagement is centered around two currently active PEBs: (1) the AI/AN PEB called theCommunity Advisory Committee has a composition that reflects as much possible the 22 AI/AN tribes inArizona within the practical limit of size (9-member PEB) and (2) the second PEB is comprised of 20 membersof whom nine are Hispanics or bilingual in English and Spanish to reflect the fact that >50% of our participantswill be Hispanics/Latinos.