This application is a competitive renewal of our long-standing Cardiovascular Research (CVR)Training Program. As a top 20 public Research I University the University of Arizona (UA) has aproven track record of mentoring research and collaborations across traditional departmentalcollege and institutional boundaries. In the last 3 years the UA has seen an unprecedentedfocus on heart vascular and lung research bringing numerous new faculty to this renewalapplication substantive key improvements in infrastructure and opportunities for our trainees togain true translational experiences.The current application continues the tradition ofdevelopingyoung investigators for successful biomedical careers via multidisciplinary training at the pre-and postdoctoral levels. Forty-four faculty with well-funded collaborative research programsprovide strength in 3 broad areas: 1) Molecular Basis of Cardiac Function 2) Signaling inVascular and Pulmonary Diseases and 3) Cardiovascular and Pulmonary Diseases Molecules to Treatments. Molecular cellular and systems approaches are complemented bycomputational/modeling proteomics/metabolomics/genomics biophysical nanotech andadvanced imaging approaches. Extensive support from the UA state-of-the-art core facilitiesand opportunities for underrepresented minority researchers (e.g. UA is top of all Research Iinstitutions for URMs in graduate school) rounds out a unique and outstanding researchenvironment for training future leaders in Cardiovascular Biomedical Research. The CVRprogram is adaptable to the specific needs and interests of each trainee. Predoctoral traineesreceive a broad background in biomedical sciences as well as exposure to interdisciplinaryresearch multiple experimental approaches and practical and ethical aspects of careers inscience. Predoctoral candidates also develop presentation and intrapersonal skills through anactive student forum journal clubs MD/PhD colloquium and a meet the speaker seminarprogram. The postdoctoral training plan ensures that trainees foster a comprehensive pathtowards independence by expanding their research focus learning new state-of-the-arttechniques and career skills particularly in grant/manuscript preparation. All trainees attendnational and international meetings and participate in symposia featuring the trainees' research.The maturation of the CVR Program incorporates a robust training plan to integrate predoctoralpostdoctoral MD/PhD and clinical trainees to align with the NIH mission of T32 translationalresearch training. Translational experiences are enhanced via active participation in weeklyclinical (Cardiology or Pulmonary Fellow) conferences. The newly developed Arizona Institutefor Clinical and Translational Science together with the new infusion of resources and projectsvia our NIH Precision Medicine Initiative Cohort Program offers all trainees unique opportunitiesto integrate with clinical medicine. 92% of the 208 trainees supported by this program over 40years remain engaged in research related positions a positive indicator of our CVR trainingprogram. We again request support for 7 predoctoral and 4 postdoctoral trainees.